Impaired Muscle Regeneration in Cancer-Associated Cachexia

Paige C. Arneson, Jason Doles

Research output: Contribution to journalShort survey

Abstract

Muscle wasting, a cardinal feature of cancer-associated cachexia (CAC), is a major clinical problem with few therapeutic options. In this Forum article we discuss cellular mechanisms of CAC, focusing on impaired muscle regeneration. We highlight muscle progenitor cell dysfunction and metabolism as two variables contributing to impaired regeneration in CAC.

Original languageEnglish (US)
JournalTrends in Cancer
DOIs
StateAccepted/In press - Jan 1 2019

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Keywords

  • cachexia
  • muscle wasting
  • regeneration
  • satellite cells

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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