Impaired Muscle Regeneration in Cancer-Associated Cachexia

Paige C. Arneson, Jason Doles

Research output: Contribution to journalShort survey

Abstract

Muscle wasting, a cardinal feature of cancer-associated cachexia (CAC), is a major clinical problem with few therapeutic options. In this Forum article we discuss cellular mechanisms of CAC, focusing on impaired muscle regeneration. We highlight muscle progenitor cell dysfunction and metabolism as two variables contributing to impaired regeneration in CAC.

Original languageEnglish (US)
JournalTrends in Cancer
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Cachexia
Regeneration
Muscles
Neoplasms
Muscle Cells
Stem Cells
Therapeutics

Keywords

  • cachexia
  • muscle wasting
  • regeneration
  • satellite cells

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Impaired Muscle Regeneration in Cancer-Associated Cachexia. / Arneson, Paige C.; Doles, Jason.

In: Trends in Cancer, 01.01.2019.

Research output: Contribution to journalShort survey

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