Impact of venous thromboembolism, venous stasis syndrome, venous outflow obstruction and venous valvular incompetence on quality of life and activities of daily living: A nested case-control study

Aneel A. Ashrani, Marc D. Silverstein, Thom W. Rooke, Brian D. Lahr, Tanya M. Petterson, Kent R. Bailey, L. Joseph Melton, John A. Heit

Research output: Contribution to journalArticle

16 Scopus citations


The role of venous stasis syndrome (VSS) mechanisms (i.e. venous outfow obstruction [VOO] and venous valvular incompetence [VVI]) on quality of life (QoL) and activities of daily living (ADL) is unknown. The objective of this study was to test the hypotheses that venous thromboembolism (VTE), VSS, VOO and VVI are associated with reduced QoL and ADL. This study is a follow-up of an incident VTE case-control study nested within a population-based inception cohort of residents from Olmsted County, MN, USA, between 1966 and 1990. The study comprised 232 Olmsted County residents with a frst lifetime VTE and 133 residents without VTE. Methods included a questionnaire and physical examination for VSS; vascular laboratory testing for VOO and VVI; assessment of QoL by SF36 and of ADL by pertinent sections from the Older Americans Resources and Services (OARS) and Arthritis Impact Measurement Scales (AIMS2) questionnaires. Of the 365 study participants, 232 (64%), 161 (44%), 43 (12%) and 136 (37%) had VTE, VSS, VOO and VVI, respectively. Prior VTE was associated with reduced ADL and increased pain, VSS with reduced physical QoL and increased pain, and VOO with reduced physical QoL and ADL. VVI was not associated with QoL or ADL. In conclusion, VSS and VOO are associated with worse physical QoL and increased pain. VOO and VTE are associated with impaired ADL. We hypothesize that rapid clearance of venous outfow obstruction in individuals with acute VTE will improve their QoL and ADL.

Original languageEnglish (US)
Pages (from-to)387-397
Number of pages11
JournalVascular Medicine
Issue number5
StatePublished - Oct 1 2010



  • activities of daily living
  • deep vein thrombosis
  • epidemiology
  • post-thrombotic syndrome
  • quality of life
  • venous stasis syndrome
  • venous thromboembolism

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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