Impact of vascular risk factors on brain structure

David S Knopman, Rosebud O Roberts

Research output: Contribution to journalArticle

Abstract

The major vascular risk factors such as diabetes and impaired glycemic control, hypertension, obesity and hyper-or dyslipidemia have been associated both with Alzheimer's disease and vascular dementia. The purpose of this review is to consider how vascular risk factors impact the expression of cognitive impairment in the elderly. The review will focus on how vascular risk factors are associated with changes in brain imaging and neuropathological changes. Midlife diabetes mellitus, hypertension and obesity are the most important vascular risk factors on the basis of their prevalence and associations with late-life cognitive impairment. The basis for their relationships to changes in brain integrity could either be through microvascular brain disease, Alzheimer pathology or both. Midlife vascular risk factors represent potentially modifiable conditions that could mitigate disease in the future.

Original languageEnglish (US)
Pages (from-to)667-678
Number of pages12
JournalAdvances in Alzheimer's Disease
Volume2
DOIs
StatePublished - 2011

Fingerprint

Brain
Alzheimer Disease
Obesity
Hypertension
Vascular Dementia
Brain Diseases
Dyslipidemias
Neuroimaging
Diabetes Mellitus
vascular factor
Pathology
Cognitive Dysfunction

Keywords

  • cognitive impairment
  • dementia
  • diabetes
  • hyperlipidemia
  • hypertension
  • obesity
  • stroke
  • vascular dementia
  • Vascular risk factors

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Impact of vascular risk factors on brain structure. / Knopman, David S; Roberts, Rosebud O.

In: Advances in Alzheimer's Disease, Vol. 2, 2011, p. 667-678.

Research output: Contribution to journalArticle

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