Impact of the H3K27M mutation on survival in pediatric high-grade glioma: a systematic review and meta-analysis

Victor M. Lu, Mohammed A. Alvi, Kerrie L. McDonald, David Daniels

Research output: Contribution to journalReview article

9 Scopus citations


In BriefThe authors pooled all currently published data on the H3K27M mutation in pediatric high-grade glioma as a prognostic factor and quantified its impact on survival.

Original languageEnglish (US)
Pages (from-to)308-316
Number of pages9
JournalJournal of neurosurgery. Pediatrics
Issue number3
StatePublished - Nov 30 2018



  • CI = confidence interval
  • diffuse intrinsic pontine glioma
  • glioblastoma
  • GRADE = Grades of Recommendation Assessment, Development and Evaluation
  • H3K27M
  • high-grade glioma
  • histone 3
  • HR = hazard ratio
  • MD = mean difference
  • midline glioma
  • NOS = Newcastle-Ottawa Scale
  • oncology
  • OS = overall survival
  • pediatric
  • pHGG = pediatric high-grade glioma
  • PRISMA = Preferred Reporting Items for Systematic Reviews and Meta-Analyses
  • prognosis
  • RE = random effects

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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