Impact of septal myectomy on diastolic function in patients with obstructive hypertrophic cardiomyopathy

Qiulan Yang, Hao Cui, Changsheng Zhu, Haibo Hu, Jianhua Lv, Yao Liu, Yang Zhang, Hartzell V. Schaff, Shuiyun Wang

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The impact of septal myectomy on diastolic function in patients with obstructive hypertrophic cardiomyopathy is not well studied. Methods: A transcatheter hemodynamic study was performed before and 3 to 6 months after septal myectomy in 12 patients with obstructive hypertrophic cardiomyopathy (HCM). Results: Postoperative hemodynamic studies were done 4.4±1.2 months after myectomy. The left ventricular outflow tract peak-to-peak gradient decreased from 83.2±43.3 mmHg preoperatively to 11.6±4.3 mmHg after myectomy (P<0.00). The left ventricular diastolic time constant (Tau) was 64.2±26.1 ms before surgery and 42.2±15.7 ms postoperatively (P=0.029). The average left atrial pressure (LAP) decreased from 20.2±7.0 to 12.1±4.5 mmHg after myectomy (P=0.008). Pulmonary artery hypertension was present in 6 patients preoperatively and remained in 2 patients after myectomy. Mean pulmonary artery pressure decreased from 29.3±16.2 to 20±6.7 mmHg after surgery (P=0.05), and the systolic pulmonary artery pressure decreased from 46±26.9 to 30.5±8.3 mmHg (P=0.048). Pulmonary vascular resistance decreased from 5.7±4.1 to 3.6±1.6 wood after surgery (P=0.032). Conclusions: Septal myectomy improved left ventricular diastolic function and subsequently relieved the right ventricular congestion in patients with obstructive HCM.

Original languageEnglish (US)
Pages (from-to)4925-4934
Number of pages10
JournalJournal of Thoracic Disease
Volume13
Issue number8
DOIs
StatePublished - Aug 2021

Keywords

  • Cardiac catheterization
  • Diastolic function
  • Myectomy surgery
  • Obstructive hypertrophic cardiomyopathy
  • Pulmonary hypertension

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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