Impact of rhabdoid differentiation on prognosis for patients with grade 4 renal cell carcinoma

Ben Y. Zhang, John C. Cheville, R. Houston Thompson, Christine M. Lohse, Stephen A. Boorjian, Bradley C. Leibovich, Brian Costello

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Renal cell carcinoma (RCC) with rhabdoid differentiation is thought to portend a poor prognosis, similar to RCC with sarcomatoid differentiation. Both features are currently classified as grade 4 RCC based on the most recent International Society of Urological Pathology (ISUP) grading system.We reviewed a large series of patients with grade 4 RCC to determine the differential effects of rhabdoid and sarcomatoid differentiation on patient outcome. We identified 406 patients with ISUP grade 4 RCC including 111 (27%) with rhabdoid differentiation. In multivariable analysis of grade 4 RCC tumors, the presence of rhabdoid differentiation was not associated with death from RCC (hazard ratio [HR]: 0.95; p = 0.75); in contrast, sarcomatoid differentiation was significantly associated with death from RCC (HR: 1.63; p <0.001). Patients with RCC with rhabdoid differentiation were significantly more likely to die of RCC than a comparison cohort of 1758 patients with grade 3 RCC (HR: 2.45; p <0.001). The novel findings of our study suggest that rhabdoid and sarcomatoid differentiation should not be grouped together when assessing risk in a patient with grade 4 RCC but support the notion that rhabdoid differentiation is appropriately placed in the ISUP grade 4 category.

Original languageEnglish (US)
Pages (from-to)5-7
Number of pages3
JournalEuropean Urology
Volume68
Issue number1
DOIs
StatePublished - 2015

Keywords

  • Prognosis
  • Renal cell carcinoma
  • Rhabdoid differentiation
  • Sarcomatoid differentiation
  • Survival

ASJC Scopus subject areas

  • Urology

Fingerprint Dive into the research topics of 'Impact of rhabdoid differentiation on prognosis for patients with grade 4 renal cell carcinoma'. Together they form a unique fingerprint.

  • Cite this

    Zhang, B. Y., Cheville, J. C., Thompson, R. H., Lohse, C. M., Boorjian, S. A., Leibovich, B. C., & Costello, B. (2015). Impact of rhabdoid differentiation on prognosis for patients with grade 4 renal cell carcinoma. European Urology, 68(1), 5-7. https://doi.org/10.1016/j.eururo.2015.01.002