Abstract
Renal cell carcinoma (RCC) with rhabdoid differentiation is thought to portend a poor prognosis, similar to RCC with sarcomatoid differentiation. Both features are currently classified as grade 4 RCC based on the most recent International Society of Urological Pathology (ISUP) grading system.We reviewed a large series of patients with grade 4 RCC to determine the differential effects of rhabdoid and sarcomatoid differentiation on patient outcome. We identified 406 patients with ISUP grade 4 RCC including 111 (27%) with rhabdoid differentiation. In multivariable analysis of grade 4 RCC tumors, the presence of rhabdoid differentiation was not associated with death from RCC (hazard ratio [HR]: 0.95; p = 0.75); in contrast, sarcomatoid differentiation was significantly associated with death from RCC (HR: 1.63; p < 0.001). Patients with RCC with rhabdoid differentiation were significantly more likely to die of RCC than a comparison cohort of 1758 patients with grade 3 RCC (HR: 2.45; p < 0.001). The novel findings of our study suggest that rhabdoid and sarcomatoid differentiation should not be grouped together when assessing risk in a patient with grade 4 RCC but support the notion that rhabdoid differentiation is appropriately placed in the ISUP grade 4 category.
Original language | English (US) |
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Pages (from-to) | 5-7 |
Number of pages | 3 |
Journal | European urology |
Volume | 68 |
Issue number | 1 |
DOIs | |
State | Published - 2015 |
Keywords
- Prognosis
- Renal cell carcinoma
- Rhabdoid differentiation
- Sarcomatoid differentiation
- Survival
ASJC Scopus subject areas
- Urology