Impact of primary tumour location on efficacy of bevacizumab plus chemotherapy in metastatic colorectal cancer

Fotios Loupakis; Herbert I. Hurwitz; Leonard Saltz; Dirk Arnold; Axel Grothey; Quynh Lan Nguyen; Stuart Osborne; Jonathan Talbot; Stefanie Srock; Heinz Josef Lenz

doi:10.1038/s41416-018-0304-6

Impact of primary tumour location on efficacy of bevacizumab plus chemotherapy in metastatic colorectal cancer

Fotios Loupakis, Herbert I. Hurwitz, Leonard Saltz, Dirk Arnold, Axel Grothey, Quynh Lan Nguyen, Stuart Osborne, Jonathan Talbot, Stefanie Srock, Heinz Josef Lenz

Medical Oncology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Background: Two first-line (1L) bevacizumab trials showed the prognostic value of primary tumour location in metastatic colorectal cancer (mCRC). In this retrospective subgroup analysis, further analysis of the predictive effect of bevacizumab is presented. Methods: Patients with sidedness information from two randomised phase III studies of bevacizumab + chemotherapy (CT) vs CT as 1L mCRC treatment were analysed retrospectively. Results: Sidedness was determined in 1590 (27% right and 73% left) of 2214 patients. Progression-free survival was improved with bevacizumab + CT vs CT in right-sided (HR = 0.75; 95% CI 0.61, 0.93; p = 0.008) and left-sided (HR = 0.76; 95% CI 0.67, 0.86; p < 0.001) mCRC (pooled analysis). Similarly, overall survival was numerically improved with bevacizumab + CT vs CT in right-sided mCRC (HR = 0.82; 95% CI 0.65, 1.03; p = 0.085), and significantly improved in left-sided mCRC (HR = 0.85; 95% CI 0.74, 0.98; p = 0.028). Conclusions: This analysis indicates that the effect of bevacizumab is independent of tumour location in mCRC.

Original language	English (US)
Pages (from-to)	1451-1455
Number of pages	5
Journal	British journal of cancer
Volume	119
Issue number	12
DOIs	https://doi.org/10.1038/s41416-018-0304-6
State	Published - Dec 11 2018

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Impact of primary tumour location on efficacy of bevacizumab plus chemotherapy in metastatic colorectal cancer",

abstract = "Background: Two first-line (1L) bevacizumab trials showed the prognostic value of primary tumour location in metastatic colorectal cancer (mCRC). In this retrospective subgroup analysis, further analysis of the predictive effect of bevacizumab is presented. Methods: Patients with sidedness information from two randomised phase III studies of bevacizumab + chemotherapy (CT) vs CT as 1L mCRC treatment were analysed retrospectively. Results: Sidedness was determined in 1590 (27% right and 73% left) of 2214 patients. Progression-free survival was improved with bevacizumab + CT vs CT in right-sided (HR = 0.75; 95% CI 0.61, 0.93; p = 0.008) and left-sided (HR = 0.76; 95% CI 0.67, 0.86; p < 0.001) mCRC (pooled analysis). Similarly, overall survival was numerically improved with bevacizumab + CT vs CT in right-sided mCRC (HR = 0.82; 95% CI 0.65, 1.03; p = 0.085), and significantly improved in left-sided mCRC (HR = 0.85; 95% CI 0.74, 0.98; p = 0.028). Conclusions: This analysis indicates that the effect of bevacizumab is independent of tumour location in mCRC.",

author = "Fotios Loupakis and Hurwitz, {Herbert I.} and Leonard Saltz and Dirk Arnold and Axel Grothey and Nguyen, {Quynh Lan} and Stuart Osborne and Jonathan Talbot and Stefanie Srock and Lenz, {Heinz Josef}",

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year = "2018",

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doi = "10.1038/s41416-018-0304-6",

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T1 - Impact of primary tumour location on efficacy of bevacizumab plus chemotherapy in metastatic colorectal cancer

AU - Loupakis, Fotios

AU - Hurwitz, Herbert I.

AU - Saltz, Leonard

AU - Arnold, Dirk

AU - Grothey, Axel

AU - Nguyen, Quynh Lan

AU - Osborne, Stuart

AU - Talbot, Jonathan

AU - Srock, Stefanie

AU - Lenz, Heinz Josef

PY - 2018/12/11

Y1 - 2018/12/11

N2 - Background: Two first-line (1L) bevacizumab trials showed the prognostic value of primary tumour location in metastatic colorectal cancer (mCRC). In this retrospective subgroup analysis, further analysis of the predictive effect of bevacizumab is presented. Methods: Patients with sidedness information from two randomised phase III studies of bevacizumab + chemotherapy (CT) vs CT as 1L mCRC treatment were analysed retrospectively. Results: Sidedness was determined in 1590 (27% right and 73% left) of 2214 patients. Progression-free survival was improved with bevacizumab + CT vs CT in right-sided (HR = 0.75; 95% CI 0.61, 0.93; p = 0.008) and left-sided (HR = 0.76; 95% CI 0.67, 0.86; p < 0.001) mCRC (pooled analysis). Similarly, overall survival was numerically improved with bevacizumab + CT vs CT in right-sided mCRC (HR = 0.82; 95% CI 0.65, 1.03; p = 0.085), and significantly improved in left-sided mCRC (HR = 0.85; 95% CI 0.74, 0.98; p = 0.028). Conclusions: This analysis indicates that the effect of bevacizumab is independent of tumour location in mCRC.

AB - Background: Two first-line (1L) bevacizumab trials showed the prognostic value of primary tumour location in metastatic colorectal cancer (mCRC). In this retrospective subgroup analysis, further analysis of the predictive effect of bevacizumab is presented. Methods: Patients with sidedness information from two randomised phase III studies of bevacizumab + chemotherapy (CT) vs CT as 1L mCRC treatment were analysed retrospectively. Results: Sidedness was determined in 1590 (27% right and 73% left) of 2214 patients. Progression-free survival was improved with bevacizumab + CT vs CT in right-sided (HR = 0.75; 95% CI 0.61, 0.93; p = 0.008) and left-sided (HR = 0.76; 95% CI 0.67, 0.86; p < 0.001) mCRC (pooled analysis). Similarly, overall survival was numerically improved with bevacizumab + CT vs CT in right-sided mCRC (HR = 0.82; 95% CI 0.65, 1.03; p = 0.085), and significantly improved in left-sided mCRC (HR = 0.85; 95% CI 0.74, 0.98; p = 0.028). Conclusions: This analysis indicates that the effect of bevacizumab is independent of tumour location in mCRC.

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Impact of primary tumour location on efficacy of bevacizumab plus chemotherapy in metastatic colorectal cancer

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