Impact of pre-transplant bone marrow plasma cell percentage on post-transplant response and survival in newly diagnosed multiple myeloma

Rajshekhar Chakraborty, Eli Muchtar, Shaji K. Kumar, Francis K. Buadi, David Dingli, Angela Dispenzieri, Suzanne R. Hayman, William J. Hogan, Prashant Kapoor, Martha Q. Lacy, Nelson Leung, Morie A. Gertz

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

We evaluated 1070 patients with newly diagnosed multiple myeloma, who completed a single line of induction therapy followed by autologous stem cell transplantation. Patients with pre-transplant <5% BMPC had a threefold likelihood of achieving stringent complete response (sCR) after transplant compared to those with BMPC ≥5% (45.6% vs. 16.3%; p < 0.0001). The median progression-free survival and overall survival from transplant for patients with pre-transplant BMPC <5% and ≥5% was 30.8 and 115.2 months compared to 20.8 and 74.1 months, respectively (p < 0.0001 for both comparisons). The effect of pre-transplant BMPC was most pronounced in patients achieving complete response or very good partial response after transplant. In conclusion, pre-transplant BMPC <5% is an important prognostic marker of long-term survival after transplant and should be routinely incorporated into pre-transplant risk stratification.

Original languageEnglish (US)
Pages (from-to)308-315
Number of pages8
JournalLeukemia and Lymphoma
Volume58
Issue number2
DOIs
StatePublished - Feb 1 2017

Keywords

  • Multiple myeloma
  • autologous stem cell transplantation
  • bone marrow plasma cells

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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