Impact of pre-transplant bone marrow plasma cell percentage on post-transplant response and survival in newly diagnosed multiple myeloma

Rajshekhar Chakraborty, Eli Muchtar, Shaji K Kumar, Francis K. Buadi, David M Dingli, Angela Dispenzieri, Suzanne R. Hayman, William Hogan, Prashant Kapoor, Martha Lacy, Nelson Leung, Morie Gertz

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

We evaluated 1070 patients with newly diagnosed multiple myeloma, who completed a single line of induction therapy followed by autologous stem cell transplantation. Patients with pre-transplant <5% BMPC had a threefold likelihood of achieving stringent complete response (sCR) after transplant compared to those with BMPC ≥5% (45.6% vs. 16.3%; p < 0.0001). The median progression-free survival and overall survival from transplant for patients with pre-transplant BMPC <5% and ≥5% was 30.8 and 115.2 months compared to 20.8 and 74.1 months, respectively (p < 0.0001 for both comparisons). The effect of pre-transplant BMPC was most pronounced in patients achieving complete response or very good partial response after transplant. In conclusion, pre-transplant BMPC <5% is an important prognostic marker of long-term survival after transplant and should be routinely incorporated into pre-transplant risk stratification.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalLeukemia and Lymphoma
DOIs
StateAccepted/In press - Jul 7 2016

Keywords

  • autologous stem cell transplantation
  • bone marrow plasma cells
  • Multiple myeloma

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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