Impact of physical activity on cancer recurrence and survival in patients with stage III colon cancer: Findings from CALGB 89803

Jeffrey A. Meyerhardt, Denise Heseltine, Donna Niedzwiecki, Donna Hollis, Leonard B. Saltz, Robert J. Mayer, James Thomas, Heidi Nelson, Renaud Whittom, Alexander Hantel, Richard L. Schilsky, Charles S. Fuchs

Research output: Contribution to journalArticle

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Abstract

Purpose: Regular physical activity reduces the risk of developing colon cancer, however, its influence on patients with established disease is unknown. Patients and Methods: We conducted a prospective observational study of 832 patients with stage III colon cancer enrolled in a randomized adjuvant chemotherapy trial. Patients reported on various recreational physical activities approximately 6 months after completion of therapy and were observed for recurrence or death. To minimize bias by occult recurrence, we excluded patients who experienced recurrence or died within 90 days of their physical activity assessment. Results: Compared with patients engaged in less than three metabolic equivalent task (MET) -hours per week of physical activity, the adjusted hazard ratio for disease-free survival was 0.51 (95% CI, 0.26 to 0.97) for 18 to 26.9 MET-hours per week and 0.55 (95% CI, 0.33 to 0.91) for 27 or more MET-hours per week. The adjusted P for trend was .01. Postdiagnosis activity was associated with similar improvements in recurrence-free survival (P for trend = .03) and overall survival (P for trend = .01). The benefit associated with physical activity was not significantly modified by sex, body mass index, number of positive lymph nodes, age, baseline performance status, or chemotherapy received. Moreover, the benefit remained unchanged even after excluding participants who developed cancer recurrence or died within 6 months of activity assessment. Conclusion: Beyond surgical resection and postoperative adjuvant chemotherapy for stage III colon cancer, for patients who survive and are recurrence free approximately 6 months after adjuvant chemotherapy, physical activity appears to reduce the risk of cancer recurrence and mortality.

Original languageEnglish (US)
Pages (from-to)3535-3541
Number of pages7
JournalJournal of Clinical Oncology
Volume24
Issue number22
DOIs
StatePublished - Aug 1 2006

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Colonic Neoplasms
Exercise
Recurrence
Metabolic Equivalent
Survival
Adjuvant Chemotherapy
Neoplasms
Disease-Free Survival
Observational Studies
Body Mass Index
Lymph Nodes
Prospective Studies
Drug Therapy
Mortality

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Meyerhardt, J. A., Heseltine, D., Niedzwiecki, D., Hollis, D., Saltz, L. B., Mayer, R. J., ... Fuchs, C. S. (2006). Impact of physical activity on cancer recurrence and survival in patients with stage III colon cancer: Findings from CALGB 89803. Journal of Clinical Oncology, 24(22), 3535-3541. https://doi.org/10.1200/JCO.2006.06.0863

Impact of physical activity on cancer recurrence and survival in patients with stage III colon cancer : Findings from CALGB 89803. / Meyerhardt, Jeffrey A.; Heseltine, Denise; Niedzwiecki, Donna; Hollis, Donna; Saltz, Leonard B.; Mayer, Robert J.; Thomas, James; Nelson, Heidi; Whittom, Renaud; Hantel, Alexander; Schilsky, Richard L.; Fuchs, Charles S.

In: Journal of Clinical Oncology, Vol. 24, No. 22, 01.08.2006, p. 3535-3541.

Research output: Contribution to journalArticle

Meyerhardt, JA, Heseltine, D, Niedzwiecki, D, Hollis, D, Saltz, LB, Mayer, RJ, Thomas, J, Nelson, H, Whittom, R, Hantel, A, Schilsky, RL & Fuchs, CS 2006, 'Impact of physical activity on cancer recurrence and survival in patients with stage III colon cancer: Findings from CALGB 89803', Journal of Clinical Oncology, vol. 24, no. 22, pp. 3535-3541. https://doi.org/10.1200/JCO.2006.06.0863
Meyerhardt, Jeffrey A. ; Heseltine, Denise ; Niedzwiecki, Donna ; Hollis, Donna ; Saltz, Leonard B. ; Mayer, Robert J. ; Thomas, James ; Nelson, Heidi ; Whittom, Renaud ; Hantel, Alexander ; Schilsky, Richard L. ; Fuchs, Charles S. / Impact of physical activity on cancer recurrence and survival in patients with stage III colon cancer : Findings from CALGB 89803. In: Journal of Clinical Oncology. 2006 ; Vol. 24, No. 22. pp. 3535-3541.
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AU - Hollis, Donna

AU - Saltz, Leonard B.

AU - Mayer, Robert J.

AU - Thomas, James

AU - Nelson, Heidi

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