Impact of peri-operative blood transfusion on the outcomes of patients undergoing radical cystectomy for urothelial carcinoma of the bladder

Luis A. Kluth, Evanguelos Xylinas, Malte Rieken, Maya El Ghouayel, Maxine Sun, Pierre I. Karakiewicz, Yair Lotan, Felix K.H. Chun, Stephen A. Boorjian, Richard K. Lee, Alberto Briganti, Morgan Rouprêt, Margit Fisch, Douglas S. Scherr, Shahrokh F. Shariat

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38 Scopus citations

Abstract

Objective To determine the association between peri-operative blood transfusion (PBT) and oncological outcomes in a large multi-institutional cohort of patients undergoing radical cystectomy (RC) for urothelial carcinoma of the bladder (UCB). Patients and Methods We conducted a retrospective analysis of 2895 patients treated with RC for UCB. Univariable and multivariable Cox regression models were used to analyse the effect of PBT administration on disease recurrence, cancer-specific mortality, and any-cause mortality. Results Patients' median (interquartile range [IQR]) age was 67 (60, 73) years and the median (IQR) follow-up was 36.1 (15, 84) months. Patients who received PBT were more likely to have advanced disease (P < 0.001), high grade tumours (P = 0.047) and nodal metastasis (P = 0.004). PBT was associated with a higher risk of disease recurrence (P = 0.003), cancer-specific mortality (P = 0.017), and any-cause mortality (P = 0.010) in univariable, but not multivariable, analyses (P > 0.05). In multivariable analyses, pathological tumour stage, pathological nodal stage, soft tissue surgical margin, lymphovascular invasion and administration of adjuvant chemotherapy were independent predictors of disease recurrence, cancer-specific mortality and any-cause mortality (all P values <0.002). Conclusions Patients with UCB who underwent RC and received PBT had a greater risk of disease recurrence, cancer-specific mortality and any-cause mortality in univariable, but not multivariable, analysis. Although the greater need for PBT with more advanced disease is probably caused by a number of factors, including surgical and cancer-related factors, the present analysis showed that the disease characteristics rather than need for PBT led to worse outcomes.

Original languageEnglish (US)
Pages (from-to)393-398
Number of pages6
JournalBJU international
Volume113
Issue number3
DOIs
StatePublished - Mar 2014

Keywords

  • bladder carcinoma
  • blood transfusion
  • outcomes
  • prognosis
  • radical cystectomy
  • urothelial carcinoma

ASJC Scopus subject areas

  • Urology

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    Kluth, L. A., Xylinas, E., Rieken, M., El Ghouayel, M., Sun, M., Karakiewicz, P. I., Lotan, Y., Chun, F. K. H., Boorjian, S. A., Lee, R. K., Briganti, A., Rouprêt, M., Fisch, M., Scherr, D. S., & Shariat, S. F. (2014). Impact of peri-operative blood transfusion on the outcomes of patients undergoing radical cystectomy for urothelial carcinoma of the bladder. BJU international, 113(3), 393-398. https://doi.org/10.1111/bju.12439