Impact of overweight on myocardial infarct size in patients undergoing primary percutaneous coronary intervention: A magnetic resonance imaging study

Gwan Hyeop Sohn, Eun Kyoung Kim, Joo Yong Hahn, Young Bin Song, Jeong Hoon Yang, Sung A. Chang, Sang Chol Lee, Yeon Hyeon Choe, Seung Hyuk Choi, Jin Ho Choi, Sang Hoon Lee, Jae K. Oh, Hyeon Cheol Gwon

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Objective: Although obesity is a risk factor for cardiovascular disease and mortality, several studies have reported that patients with obesity who have suffered acute myocardial infarction or have undergone percutaneous coronary intervention (PCI) have better clinical outcomes than their normal weight counterparts. We evaluated the impact of overweight on myocardial infarct size in patients undergoing primary PCI for ST-segment elevation myocardial infarction (STEMI). Methods: We performed contrast-enhanced magnetic resonance imaging on 193 patients undergoing primary PCI for STEMI. Infarct size was measured with delayed-enhancement imaging and the area at risk was quantified on T2-weighted images. Results: Baseline characteristics and angiographic findings were not significantly different between the normal weight group (body mass index [BMI]<25kg/m2, n=110) and the overweight group (BMI≥25kg/m2, n=83). The median percent infarct volume and area at risk were significantly smaller in the overweight group than the normal weight group (17.9% [9.0-24.9%] vs. 20.8% [11.4-33.1%], p=0.04 and 29.4% [20.5-37.6%] vs. 36.0% [25.7-49.6%], p<0.01, respectively). However, the myocardial salvage index was not different between the 2 groups (overweight group vs. normal weight group, 43.2% vs. 39.2%, p=0.69). BMI≥25kg/m2 was an independent predictor of smaller infarct size in multivariate analysis (Odds ratio 0.51, 95% Confidence interval 0.27-0.97, p=0.039). Conclusion: Overweight (BMI≥25kg/m2) is independently associated with smaller infarct size in patients undergoing primary PCI for STEMI.

Original languageEnglish (US)
Pages (from-to)570-575
Number of pages6
JournalAtherosclerosis
Volume235
Issue number2
DOIs
StatePublished - Aug 2014

Keywords

  • Magnetic resonance imaging
  • Myocardial infarction
  • Obesity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Sohn, G. H., Kim, E. K., Hahn, J. Y., Song, Y. B., Yang, J. H., Chang, S. A., Lee, S. C., Choe, Y. H., Choi, S. H., Choi, J. H., Lee, S. H., Oh, J. K., & Gwon, H. C. (2014). Impact of overweight on myocardial infarct size in patients undergoing primary percutaneous coronary intervention: A magnetic resonance imaging study. Atherosclerosis, 235(2), 570-575. https://doi.org/10.1016/j.atherosclerosis.2014.05.961