Impact of overweight on myocardial infarct size in patients undergoing primary percutaneous coronary intervention: A magnetic resonance imaging study

Gwan Hyeop Sohn, Eun Kyoung Kim, Joo Yong Hahn, Young Bin Song, Jeong Hoon Yang, Sung A. Chang, Sang Chol Lee, Yeon Hyeon Choe, Seung Hyuk Choi, Jin Ho Choi, Sang Hoon Lee, Jae Kuen Oh, Hyeon Cheol Gwon

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: Although obesity is a risk factor for cardiovascular disease and mortality, several studies have reported that patients with obesity who have suffered acute myocardial infarction or have undergone percutaneous coronary intervention (PCI) have better clinical outcomes than their normal weight counterparts. We evaluated the impact of overweight on myocardial infarct size in patients undergoing primary PCI for ST-segment elevation myocardial infarction (STEMI). Methods: We performed contrast-enhanced magnetic resonance imaging on 193 patients undergoing primary PCI for STEMI. Infarct size was measured with delayed-enhancement imaging and the area at risk was quantified on T2-weighted images. Results: Baseline characteristics and angiographic findings were not significantly different between the normal weight group (body mass index [BMI]<25kg/m2, n=110) and the overweight group (BMI≥25kg/m2, n=83). The median percent infarct volume and area at risk were significantly smaller in the overweight group than the normal weight group (17.9% [9.0-24.9%] vs. 20.8% [11.4-33.1%], p=0.04 and 29.4% [20.5-37.6%] vs. 36.0% [25.7-49.6%], p<0.01, respectively). However, the myocardial salvage index was not different between the 2 groups (overweight group vs. normal weight group, 43.2% vs. 39.2%, p=0.69). BMI≥25kg/m2 was an independent predictor of smaller infarct size in multivariate analysis (Odds ratio 0.51, 95% Confidence interval 0.27-0.97, p=0.039). Conclusion: Overweight (BMI≥25kg/m2) is independently associated with smaller infarct size in patients undergoing primary PCI for STEMI.

Original languageEnglish (US)
Pages (from-to)570-575
Number of pages6
JournalAtherosclerosis
Volume235
Issue number2
DOIs
StatePublished - Aug 1 2015
Externally publishedYes

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Percutaneous Coronary Intervention
Myocardial Infarction
Magnetic Resonance Imaging
Weights and Measures
Obesity
Body Mass Index
Cardiovascular Diseases
Multivariate Analysis
Odds Ratio
Confidence Intervals
Mortality

Keywords

  • Magnetic resonance imaging
  • Myocardial infarction
  • Obesity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Impact of overweight on myocardial infarct size in patients undergoing primary percutaneous coronary intervention : A magnetic resonance imaging study. / Sohn, Gwan Hyeop; Kim, Eun Kyoung; Hahn, Joo Yong; Song, Young Bin; Yang, Jeong Hoon; Chang, Sung A.; Lee, Sang Chol; Choe, Yeon Hyeon; Choi, Seung Hyuk; Choi, Jin Ho; Lee, Sang Hoon; Oh, Jae Kuen; Gwon, Hyeon Cheol.

In: Atherosclerosis, Vol. 235, No. 2, 01.08.2015, p. 570-575.

Research output: Contribution to journalArticle

Sohn, GH, Kim, EK, Hahn, JY, Song, YB, Yang, JH, Chang, SA, Lee, SC, Choe, YH, Choi, SH, Choi, JH, Lee, SH, Oh, JK & Gwon, HC 2015, 'Impact of overweight on myocardial infarct size in patients undergoing primary percutaneous coronary intervention: A magnetic resonance imaging study', Atherosclerosis, vol. 235, no. 2, pp. 570-575. https://doi.org/10.1016/j.atherosclerosis.2014.05.961
Sohn, Gwan Hyeop ; Kim, Eun Kyoung ; Hahn, Joo Yong ; Song, Young Bin ; Yang, Jeong Hoon ; Chang, Sung A. ; Lee, Sang Chol ; Choe, Yeon Hyeon ; Choi, Seung Hyuk ; Choi, Jin Ho ; Lee, Sang Hoon ; Oh, Jae Kuen ; Gwon, Hyeon Cheol. / Impact of overweight on myocardial infarct size in patients undergoing primary percutaneous coronary intervention : A magnetic resonance imaging study. In: Atherosclerosis. 2015 ; Vol. 235, No. 2. pp. 570-575.
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abstract = "Objective: Although obesity is a risk factor for cardiovascular disease and mortality, several studies have reported that patients with obesity who have suffered acute myocardial infarction or have undergone percutaneous coronary intervention (PCI) have better clinical outcomes than their normal weight counterparts. We evaluated the impact of overweight on myocardial infarct size in patients undergoing primary PCI for ST-segment elevation myocardial infarction (STEMI). Methods: We performed contrast-enhanced magnetic resonance imaging on 193 patients undergoing primary PCI for STEMI. Infarct size was measured with delayed-enhancement imaging and the area at risk was quantified on T2-weighted images. Results: Baseline characteristics and angiographic findings were not significantly different between the normal weight group (body mass index [BMI]<25kg/m2, n=110) and the overweight group (BMI≥25kg/m2, n=83). The median percent infarct volume and area at risk were significantly smaller in the overweight group than the normal weight group (17.9{\%} [9.0-24.9{\%}] vs. 20.8{\%} [11.4-33.1{\%}], p=0.04 and 29.4{\%} [20.5-37.6{\%}] vs. 36.0{\%} [25.7-49.6{\%}], p<0.01, respectively). However, the myocardial salvage index was not different between the 2 groups (overweight group vs. normal weight group, 43.2{\%} vs. 39.2{\%}, p=0.69). BMI≥25kg/m2 was an independent predictor of smaller infarct size in multivariate analysis (Odds ratio 0.51, 95{\%} Confidence interval 0.27-0.97, p=0.039). Conclusion: Overweight (BMI≥25kg/m2) is independently associated with smaller infarct size in patients undergoing primary PCI for STEMI.",
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T1 - Impact of overweight on myocardial infarct size in patients undergoing primary percutaneous coronary intervention

T2 - A magnetic resonance imaging study

AU - Sohn, Gwan Hyeop

AU - Kim, Eun Kyoung

AU - Hahn, Joo Yong

AU - Song, Young Bin

AU - Yang, Jeong Hoon

AU - Chang, Sung A.

AU - Lee, Sang Chol

AU - Choe, Yeon Hyeon

AU - Choi, Seung Hyuk

AU - Choi, Jin Ho

AU - Lee, Sang Hoon

AU - Oh, Jae Kuen

AU - Gwon, Hyeon Cheol

PY - 2015/8/1

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N2 - Objective: Although obesity is a risk factor for cardiovascular disease and mortality, several studies have reported that patients with obesity who have suffered acute myocardial infarction or have undergone percutaneous coronary intervention (PCI) have better clinical outcomes than their normal weight counterparts. We evaluated the impact of overweight on myocardial infarct size in patients undergoing primary PCI for ST-segment elevation myocardial infarction (STEMI). Methods: We performed contrast-enhanced magnetic resonance imaging on 193 patients undergoing primary PCI for STEMI. Infarct size was measured with delayed-enhancement imaging and the area at risk was quantified on T2-weighted images. Results: Baseline characteristics and angiographic findings were not significantly different between the normal weight group (body mass index [BMI]<25kg/m2, n=110) and the overweight group (BMI≥25kg/m2, n=83). The median percent infarct volume and area at risk were significantly smaller in the overweight group than the normal weight group (17.9% [9.0-24.9%] vs. 20.8% [11.4-33.1%], p=0.04 and 29.4% [20.5-37.6%] vs. 36.0% [25.7-49.6%], p<0.01, respectively). However, the myocardial salvage index was not different between the 2 groups (overweight group vs. normal weight group, 43.2% vs. 39.2%, p=0.69). BMI≥25kg/m2 was an independent predictor of smaller infarct size in multivariate analysis (Odds ratio 0.51, 95% Confidence interval 0.27-0.97, p=0.039). Conclusion: Overweight (BMI≥25kg/m2) is independently associated with smaller infarct size in patients undergoing primary PCI for STEMI.

AB - Objective: Although obesity is a risk factor for cardiovascular disease and mortality, several studies have reported that patients with obesity who have suffered acute myocardial infarction or have undergone percutaneous coronary intervention (PCI) have better clinical outcomes than their normal weight counterparts. We evaluated the impact of overweight on myocardial infarct size in patients undergoing primary PCI for ST-segment elevation myocardial infarction (STEMI). Methods: We performed contrast-enhanced magnetic resonance imaging on 193 patients undergoing primary PCI for STEMI. Infarct size was measured with delayed-enhancement imaging and the area at risk was quantified on T2-weighted images. Results: Baseline characteristics and angiographic findings were not significantly different between the normal weight group (body mass index [BMI]<25kg/m2, n=110) and the overweight group (BMI≥25kg/m2, n=83). The median percent infarct volume and area at risk were significantly smaller in the overweight group than the normal weight group (17.9% [9.0-24.9%] vs. 20.8% [11.4-33.1%], p=0.04 and 29.4% [20.5-37.6%] vs. 36.0% [25.7-49.6%], p<0.01, respectively). However, the myocardial salvage index was not different between the 2 groups (overweight group vs. normal weight group, 43.2% vs. 39.2%, p=0.69). BMI≥25kg/m2 was an independent predictor of smaller infarct size in multivariate analysis (Odds ratio 0.51, 95% Confidence interval 0.27-0.97, p=0.039). Conclusion: Overweight (BMI≥25kg/m2) is independently associated with smaller infarct size in patients undergoing primary PCI for STEMI.

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KW - Myocardial infarction

KW - Obesity

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