Impact of microsatellite status in early-onset colonic cancer

Alexandra M. Zaborowski; Ahmed Abdile Michel Adamina; Felix Aigner; Laura D'Allens; Caterina Allmer; Andrea Álvarez; Rocio Anula; Mihailo Andric; Sam Atallah Simon Bach; Miklosh Bala; Marie Barussaud; Augustinas Bausys; Andrew Beggs; Felipe Bellolio; Melissa Rose Bennett; Anton Berdinskikh; Vicki Bevan; Sebastiano Biondo; Gabriele Bislenghi; Marc Bludau; Nelleke Brouwer; Carl Brown; Christiane Bruns; Daniel D. Buchanan; Pamela Buchwald; Jacobus W.A. Burger; Nikita Burlov; Michela Campanelli; Maylis Capdepont; Michele Carvello; Hwee Hoon Chew; Dimitri Christoforidis; David Clark; Marta Climent; Rowan Collinson; Kyle G. Cologne; Tomas Contreras; Roland Croner; Ian R. Daniels; Giovanni Dapri; Justin Davies; Paolo Delrio; Quentin Denost; Michael Deutsch; Andre Dias; Andre D'Hoore; Evgeniy Drozdov; Daniel Duek; Malcolm Dunlop; Adam Dziki; Aleksandra Edmundson; Sergey Efetov; Alaa El-Hussuna; Brodie Elliot; Sameh Emile; Eloy Espin; Martyn Evans; Seraina Faes; Omar Faiz; Nuno Figueiredo; Fergal Fleming; Caterina Foppa; George Fowler; Matteo Frasson; Tim Forgan; Frank Frizelle; Shamil Gadaev; Jose Gellona; Tamara Glyn; Barisic Goran; Emma Greenwood; Marianne G. Guren; Stephanie Guillon; Ida Gutlic; Dieter Hahnloser; Heather Hampel; Ann Hanly; Hirotoshi Hasegawa; Lene Hjerrild Iversen; Andrew Hill; James Hill; Jiri Hoch; Roel Hompes; Luis Hurtado; Fabiano Iaquinandi; Ugne Imbrasaite; Rumana Islam; Mehrenah D. Jafari; Andrea Jimenez Salido; Marta Jimenez-Toscano; Yukihide Kanemitsu; Aleksei Karachun; Ahmer A. Karimuddin; Deborah S. Keller; Justin Kelly; Rory Kennelly; Gleb Khrykov; Peter Kocian; Cherry Koh; Neils Kok; Katrina A. Knight; Joep Knol; Christos Kontovounisios; Hartwig Korner; Zoran Krivokapic; Irmgard Kronberger; Hidde Maarten Kroon; Marius Kryzauskas; Said Kural; Miranda Kusters; Zaher Lakkis; Timur Lankov; David Larson; György Lázár; Kai Yin Lee; Suk Hwan Lee; Jeremie H. Lefèvre; Anna Lepisto; Christopher Lieu; Lynette Loi; Craig Lynch; Helene Maillou-Martinaud; Annalisa Maroli; Sean Martin; Anna Martling; Klaus E. Matzel; Julio Mayol; Frank McDermott; Guillaume Meurette; Monica Millan; Martin Mitteregger; Andrei Moiseenko; John R.T. Monson; Stefan Morarasu; Konosuke Moritani; Gabriela Möslein; Martino Munini; Caio Nahas; Sergio Nahas; Ionut Negoi; Anastasia Novikova; Misael Ocares; Koji Okabayashi; Alexandra Olkina; Luis Oñate-Ocaña; Jaime Otero; Cihan Ozen; Ugo Pace; Guilherme Pagin São Julião; Lidiia Panaiotti; Yves Panis; Demetris Papamichael; Swati Patel; Juan Carlos Patrón Uriburu; Sze Lin Peng; Miguel Pera; Rodrigo O. Perez; Alexei Petrov; Frank Pfeffer; Terry P. Phang; Tomas Poskus; Heather Pringle; David Proud; Ivana Raguz; Nuno Rama; Shahnawaz Rasheed; Manoj J. Raval; Daniela Rega; Christoph Reissfelder; Juan Carlos Reyes Meneses; Frederic Ris; Stefan Riss; Homero Rodriguez-Zentner; Campbell S. Roxburgh; Avanish Saklani; Tarik Sammour; Deborah Saraste; Martin Schneider; Ryo Seishima; Aleksandar Sekulic; Toni Seppala; Kieran Sheahan; Alexandra Shlomina; Guiseppe Sigismondo; Tongplaew Singnomklao; Leandro Siragusa; Neil Smart; Alejandro Solis-Peña; Antonino Spinelli; Roxane D. Staiger; Michael J. Stamos; Scott Steele; Ker Kan Tan; Pieter J. Tanis; Paris Tekkis; Biniam Teklay; Sabrina Tengku; Petr Tsarkov; Matthias Turina; Alexis Ulrich; Bruna B. Vailati; Meike Van Harten; Cornelis Verhoef; Satish Warrier; Steven Wexner; Hans De Wilt; Benjamin A. Weinberg; Cameron Wells; Albert Wolthuis; Evangelos Xynos; Nancy You; Alexander Zakharenko; Justino Zeballos; Jonathan Zhou; Des C. Winter

doi:10.1093/bjs/znac108

Impact of microsatellite status in early-onset colonic cancer

Alexandra M. Zaborowski, Ahmed Abdile Michel Adamina, Felix Aigner, Laura D'Allens, Caterina Allmer, Andrea Álvarez, Rocio Anula, Mihailo Andric, Sam Atallah Simon Bach, Miklosh Bala, Marie Barussaud, Augustinas Bausys, Andrew Beggs, Felipe Bellolio, Melissa Rose Bennett, Anton Berdinskikh, Vicki Bevan, Sebastiano Biondo, Gabriele Bislenghi, Marc BludauNelleke Brouwer, Carl Brown, Christiane Bruns, Daniel D. Buchanan, Pamela Buchwald, Jacobus W.A. Burger, Nikita Burlov, Michela Campanelli, Maylis Capdepont, Michele Carvello, Hwee Hoon Chew, Dimitri Christoforidis, David Clark, Marta Climent, Rowan Collinson, Kyle G. Cologne, Tomas Contreras, Roland Croner, Ian R. Daniels, Giovanni Dapri, Justin Davies, Paolo Delrio, Quentin Denost, Michael Deutsch, Andre Dias, Andre D'Hoore, Evgeniy Drozdov, Daniel Duek, Malcolm Dunlop, Adam Dziki, Aleksandra Edmundson, Sergey Efetov, Alaa El-Hussuna, Brodie Elliot, Sameh Emile, Eloy Espin, Martyn Evans, Seraina Faes, Omar Faiz, Nuno Figueiredo, Fergal Fleming, Caterina Foppa, George Fowler, Matteo Frasson, Tim Forgan, Frank Frizelle, Shamil Gadaev, Jose Gellona, Tamara Glyn, Barisic Goran, Emma Greenwood, Marianne G. Guren, Stephanie Guillon, Ida Gutlic, Dieter Hahnloser, Heather Hampel, Ann Hanly, Hirotoshi Hasegawa, Lene Hjerrild Iversen, Andrew Hill, James Hill, Jiri Hoch, Roel Hompes, Luis Hurtado, Fabiano Iaquinandi, Ugne Imbrasaite, Rumana Islam, Mehrenah D. Jafari, Andrea Jimenez Salido, Marta Jimenez-Toscano, Yukihide Kanemitsu, Aleksei Karachun, Ahmer A. Karimuddin, Deborah S. Keller, Justin Kelly, Rory Kennelly, Gleb Khrykov, Peter Kocian, Cherry Koh, Neils Kok, Katrina A. Knight, Joep Knol, Christos Kontovounisios, Hartwig Korner, Zoran Krivokapic, Irmgard Kronberger, Hidde Maarten Kroon, Marius Kryzauskas, Said Kural, Miranda Kusters, Zaher Lakkis, Timur Lankov, David Larson, György Lázár, Kai Yin Lee, Suk Hwan Lee, Jeremie H. Lefèvre, Anna Lepisto, Christopher Lieu, Lynette Loi, Craig Lynch, Helene Maillou-Martinaud, Annalisa Maroli, Sean Martin, Anna Martling, Klaus E. Matzel, Julio Mayol, Frank McDermott, Guillaume Meurette, Monica Millan, Martin Mitteregger, Andrei Moiseenko, John R.T. Monson, Stefan Morarasu, Konosuke Moritani, Gabriela Möslein, Martino Munini, Caio Nahas, Sergio Nahas, Ionut Negoi, Anastasia Novikova, Misael Ocares, Koji Okabayashi, Alexandra Olkina, Luis Oñate-Ocaña, Jaime Otero, Cihan Ozen, Ugo Pace, Guilherme Pagin São Julião, Lidiia Panaiotti, Yves Panis, Demetris Papamichael, Swati Patel, Juan Carlos Patrón Uriburu, Sze Lin Peng, Miguel Pera, Rodrigo O. Perez, Alexei Petrov, Frank Pfeffer, Terry P. Phang, Tomas Poskus, Heather Pringle, David Proud, Ivana Raguz, Nuno Rama, Shahnawaz Rasheed, Manoj J. Raval, Daniela Rega, Christoph Reissfelder, Juan Carlos Reyes Meneses, Frederic Ris, Stefan Riss, Homero Rodriguez-Zentner, Campbell S. Roxburgh, Avanish Saklani, Tarik Sammour, Deborah Saraste, Martin Schneider, Ryo Seishima, Aleksandar Sekulic, Toni Seppala, Kieran Sheahan, Alexandra Shlomina, Guiseppe Sigismondo, Tongplaew Singnomklao, Leandro Siragusa, Neil Smart, Alejandro Solis-Peña, Antonino Spinelli, Roxane D. Staiger, Michael J. Stamos, Scott Steele, Ker Kan Tan, Pieter J. Tanis, Paris Tekkis, Biniam Teklay, Sabrina Tengku, Petr Tsarkov, Matthias Turina, Alexis Ulrich, Bruna B. Vailati, Meike Van Harten, Cornelis Verhoef, Satish Warrier, Steven Wexner, Hans De Wilt, Benjamin A. Weinberg, Cameron Wells, Albert Wolthuis, Evangelos Xynos, Nancy You, Alexander Zakharenko, Justino Zeballos, Jonathan Zhou, Des C. Winter

Colon and Rectal Surgery

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The molecular profile of early-onset colonic cancer is undefined. This study evaluated clinicopathological features and oncological outcomes of young patients with colonic cancer according to microsatellite status. Methods: Anonymized data from an international collaboration were analysed. Criteria for inclusion were patients younger than 50 years diagnosed with stage I-III colonic cancer that was surgically resected. Clinicopathological features, microsatellite status, and disease-specific outcomes were evaluated. Results: A total of 650 patients fulfilled the criteria for inclusion. Microsatellite instability (MSI) was identified in 170 (26.2 per cent), whereas 480 had microsatellite-stable (MSS) tumours (relative risk of MSI 2.5 compared with older patients). MSI was associated with a family history of colorectal cancer and lesions in the proximal colon. The proportions with pathological node-positive disease (45.9 versus 45.6 per cent; P = 1.000) and tumour budding (20.3 versus 20.5 per cent; P = 1.000) were similar in the two groups. Patients with MSI tumours were more likely to have BRAF (22.5 versus 6.9 per cent; P < 0.001) and KRAS (40.0 versus 24.2 per cent; P = 0.006) mutations, and a hereditary cancer syndrome (30.0 versus 5.0 per cent; P < 0.001; relative risk 6). Five-year disease-free survival rates in the MSI group were 95.0, 92.0, and 80.0 per cent for patients with stage I, II, and III tumours, compared with 88.0, 88.0, and 65.0 per cent in the MSS group (P = 0.753, P = 0.487, and P = 0.105 respectively). Conclusion: Patients with early-onset colonic cancer have a high risk of MSI and defined genetic conditions. Those with MSI tumours have more adverse pathology (budding, KRAS/BRAF mutations, and nodal metastases) than older patients with MSI cancers.

Original language	English (US)
Pages (from-to)	632-636
Number of pages	5
Journal	British Journal of Surgery
Volume	109
Issue number	7
DOIs	https://doi.org/10.1093/bjs/znac108
State	Published - Jul 1 2022

ASJC Scopus subject areas

Surgery

Access to Document

10.1093/bjs/znac108

Cite this

Zaborowski, A. M., Adamina, A. A. M., Aigner, F., D'Allens, L., Allmer, C., Álvarez, A., Anula, R., Andric, M., Bach, S. A. S., Bala, M., Barussaud, M., Bausys, A., Beggs, A., Bellolio, F., Bennett, M. R., Berdinskikh, A., Bevan, V., Biondo, S., Bislenghi, G., ... Winter, D. C. (2022). Impact of microsatellite status in early-onset colonic cancer. British Journal of Surgery, 109(7), 632-636. https://doi.org/10.1093/bjs/znac108

Zaborowski, AM, Adamina, AAM, Aigner, F, D'Allens, L, Allmer, C, Álvarez, A, Anula, R, Andric, M, Bach, SAS, Bala, M, Barussaud, M, Bausys, A, Beggs, A, Bellolio, F, Bennett, MR, Berdinskikh, A, Bevan, V, Biondo, S, Bislenghi, G, Bludau, M, Brouwer, N, Brown, C, Bruns, C, Buchanan, DD, Buchwald, P, Burger, JWA, Burlov, N, Campanelli, M, Capdepont, M, Carvello, M, Chew, HH, Christoforidis, D, Clark, D, Climent, M, Collinson, R, Cologne, KG, Contreras, T, Croner, R, Daniels, IR, Dapri, G, Davies, J, Delrio, P, Denost, Q, Deutsch, M, Dias, A, D'Hoore, A, Drozdov, E, Duek, D, Dunlop, M, Dziki, A, Edmundson, A, Efetov, S, El-Hussuna, A, Elliot, B, Emile, S, Espin, E, Evans, M, Faes, S, Faiz, O, Figueiredo, N, Fleming, F, Foppa, C, Fowler, G, Frasson, M, Forgan, T, Frizelle, F, Gadaev, S, Gellona, J, Glyn, T, Goran, B, Greenwood, E, Guren, MG, Guillon, S, Gutlic, I, Hahnloser, D, Hampel, H, Hanly, A, Hasegawa, H, Iversen, LH, Hill, A, Hill, J, Hoch, J, Hompes, R, Hurtado, L, Iaquinandi, F, Imbrasaite, U, Islam, R, Jafari, MD, Salido, AJ, Jimenez-Toscano, M, Kanemitsu, Y, Karachun, A, Karimuddin, AA, Keller, DS, Kelly, J, Kennelly, R, Khrykov, G, Kocian, P, Koh, C, Kok, N, Knight, KA, Knol, J, Kontovounisios, C, Korner, H, Krivokapic, Z, Kronberger, I, Kroon, HM, Kryzauskas, M, Kural, S, Kusters, M, Lakkis, Z, Lankov, T, Larson, D, Lázár, G, Lee, KY, Lee, SH, Lefèvre, JH, Lepisto, A, Lieu, C, Loi, L, Lynch, C, Maillou-Martinaud, H, Maroli, A, Martin, S, Martling, A, Matzel, KE, Mayol, J, McDermott, F, Meurette, G, Millan, M, Mitteregger, M, Moiseenko, A, Monson, JRT, Morarasu, S, Moritani, K, Möslein, G, Munini, M, Nahas, C, Nahas, S, Negoi, I, Novikova, A, Ocares, M, Okabayashi, K, Olkina, A, Oñate-Ocaña, L, Otero, J, Ozen, C, Pace, U, Julião, GPS, Panaiotti, L, Panis, Y, Papamichael, D, Patel, S, Uriburu, JCP, Peng, SL, Pera, M, Perez, RO, Petrov, A, Pfeffer, F, Phang, TP, Poskus, T, Pringle, H, Proud, D, Raguz, I, Rama, N, Rasheed, S, Raval, MJ, Rega, D, Reissfelder, C, Meneses, JCR, Ris, F, Riss, S, Rodriguez-Zentner, H, Roxburgh, CS, Saklani, A, Sammour, T, Saraste, D, Schneider, M, Seishima, R, Sekulic, A, Seppala, T, Sheahan, K, Shlomina, A, Sigismondo, G, Singnomklao, T, Siragusa, L, Smart, N, Solis-Peña, A, Spinelli, A, Staiger, RD, Stamos, MJ, Steele, S, Tan, KK, Tanis, PJ, Tekkis, P, Teklay, B, Tengku, S, Tsarkov, P, Turina, M, Ulrich, A, Vailati, BB, Van Harten, M, Verhoef, C, Warrier, S, Wexner, S, De Wilt, H, Weinberg, BA, Wells, C, Wolthuis, A, Xynos, E, You, N, Zakharenko, A, Zeballos, J, Zhou, J & Winter, DC 2022, 'Impact of microsatellite status in early-onset colonic cancer', British Journal of Surgery, vol. 109, no. 7, pp. 632-636. https://doi.org/10.1093/bjs/znac108

@article{8c5d756aae1c43ad8ba58168cca2bc35,

title = "Impact of microsatellite status in early-onset colonic cancer",

abstract = "Background: The molecular profile of early-onset colonic cancer is undefined. This study evaluated clinicopathological features and oncological outcomes of young patients with colonic cancer according to microsatellite status. Methods: Anonymized data from an international collaboration were analysed. Criteria for inclusion were patients younger than 50 years diagnosed with stage I-III colonic cancer that was surgically resected. Clinicopathological features, microsatellite status, and disease-specific outcomes were evaluated. Results: A total of 650 patients fulfilled the criteria for inclusion. Microsatellite instability (MSI) was identified in 170 (26.2 per cent), whereas 480 had microsatellite-stable (MSS) tumours (relative risk of MSI 2.5 compared with older patients). MSI was associated with a family history of colorectal cancer and lesions in the proximal colon. The proportions with pathological node-positive disease (45.9 versus 45.6 per cent; P = 1.000) and tumour budding (20.3 versus 20.5 per cent; P = 1.000) were similar in the two groups. Patients with MSI tumours were more likely to have BRAF (22.5 versus 6.9 per cent; P < 0.001) and KRAS (40.0 versus 24.2 per cent; P = 0.006) mutations, and a hereditary cancer syndrome (30.0 versus 5.0 per cent; P < 0.001; relative risk 6). Five-year disease-free survival rates in the MSI group were 95.0, 92.0, and 80.0 per cent for patients with stage I, II, and III tumours, compared with 88.0, 88.0, and 65.0 per cent in the MSS group (P = 0.753, P = 0.487, and P = 0.105 respectively). Conclusion: Patients with early-onset colonic cancer have a high risk of MSI and defined genetic conditions. Those with MSI tumours have more adverse pathology (budding, KRAS/BRAF mutations, and nodal metastases) than older patients with MSI cancers.",

author = "Zaborowski, {Alexandra M.} and Adamina, {Ahmed Abdile Michel} and Felix Aigner and Laura D'Allens and Caterina Allmer and Andrea {\'A}lvarez and Rocio Anula and Mihailo Andric and Bach, {Sam Atallah Simon} and Miklosh Bala and Marie Barussaud and Augustinas Bausys and Andrew Beggs and Felipe Bellolio and Bennett, {Melissa Rose} and Anton Berdinskikh and Vicki Bevan and Sebastiano Biondo and Gabriele Bislenghi and Marc Bludau and Nelleke Brouwer and Carl Brown and Christiane Bruns and Buchanan, {Daniel D.} and Pamela Buchwald and Burger, {Jacobus W.A.} and Nikita Burlov and Michela Campanelli and Maylis Capdepont and Michele Carvello and Chew, {Hwee Hoon} and Dimitri Christoforidis and David Clark and Marta Climent and Rowan Collinson and Cologne, {Kyle G.} and Tomas Contreras and Roland Croner and Daniels, {Ian R.} and Giovanni Dapri and Justin Davies and Paolo Delrio and Quentin Denost and Michael Deutsch and Andre Dias and Andre D'Hoore and Evgeniy Drozdov and Daniel Duek and Malcolm Dunlop and Adam Dziki and Aleksandra Edmundson and Sergey Efetov and Alaa El-Hussuna and Brodie Elliot and Sameh Emile and Eloy Espin and Martyn Evans and Seraina Faes and Omar Faiz and Nuno Figueiredo and Fergal Fleming and Caterina Foppa and George Fowler and Matteo Frasson and Tim Forgan and Frank Frizelle and Shamil Gadaev and Jose Gellona and Tamara Glyn and Barisic Goran and Emma Greenwood and Guren, {Marianne G.} and Stephanie Guillon and Ida Gutlic and Dieter Hahnloser and Heather Hampel and Ann Hanly and Hirotoshi Hasegawa and Iversen, {Lene Hjerrild} and Andrew Hill and James Hill and Jiri Hoch and Roel Hompes and Luis Hurtado and Fabiano Iaquinandi and Ugne Imbrasaite and Rumana Islam and Jafari, {Mehrenah D.} and Salido, {Andrea Jimenez} and Marta Jimenez-Toscano and Yukihide Kanemitsu and Aleksei Karachun and Karimuddin, {Ahmer A.} and Keller, {Deborah S.} and Justin Kelly and Rory Kennelly and Gleb Khrykov and Peter Kocian and Cherry Koh and Neils Kok and Knight, {Katrina A.} and Joep Knol and Christos Kontovounisios and Hartwig Korner and Zoran Krivokapic and Irmgard Kronberger and Kroon, {Hidde Maarten} and Marius Kryzauskas and Said Kural and Miranda Kusters and Zaher Lakkis and Timur Lankov and David Larson and Gy{\"o}rgy L{\'a}z{\'a}r and Lee, {Kai Yin} and Lee, {Suk Hwan} and Lef{\`e}vre, {Jeremie H.} and Anna Lepisto and Christopher Lieu and Lynette Loi and Craig Lynch and Helene Maillou-Martinaud and Annalisa Maroli and Sean Martin and Anna Martling and Matzel, {Klaus E.} and Julio Mayol and Frank McDermott and Guillaume Meurette and Monica Millan and Martin Mitteregger and Andrei Moiseenko and Monson, {John R.T.} and Stefan Morarasu and Konosuke Moritani and Gabriela M{\"o}slein and Martino Munini and Caio Nahas and Sergio Nahas and Ionut Negoi and Anastasia Novikova and Misael Ocares and Koji Okabayashi and Alexandra Olkina and Luis O{\~n}ate-Oca{\~n}a and Jaime Otero and Cihan Ozen and Ugo Pace and Juli{\~a}o, {Guilherme Pagin S{\~a}o} and Lidiia Panaiotti and Yves Panis and Demetris Papamichael and Swati Patel and Uriburu, {Juan Carlos Patr{\'o}n} and Peng, {Sze Lin} and Miguel Pera and Perez, {Rodrigo O.} and Alexei Petrov and Frank Pfeffer and Phang, {Terry P.} and Tomas Poskus and Heather Pringle and David Proud and Ivana Raguz and Nuno Rama and Shahnawaz Rasheed and Raval, {Manoj J.} and Daniela Rega and Christoph Reissfelder and Meneses, {Juan Carlos Reyes} and Frederic Ris and Stefan Riss and Homero Rodriguez-Zentner and Roxburgh, {Campbell S.} and Avanish Saklani and Tarik Sammour and Deborah Saraste and Martin Schneider and Ryo Seishima and Aleksandar Sekulic and Toni Seppala and Kieran Sheahan and Alexandra Shlomina and Guiseppe Sigismondo and Tongplaew Singnomklao and Leandro Siragusa and Neil Smart and Alejandro Solis-Pe{\~n}a and Antonino Spinelli and Staiger, {Roxane D.} and Stamos, {Michael J.} and Scott Steele and Tan, {Ker Kan} and Tanis, {Pieter J.} and Paris Tekkis and Biniam Teklay and Sabrina Tengku and Petr Tsarkov and Matthias Turina and Alexis Ulrich and Vailati, {Bruna B.} and {Van Harten}, Meike and Cornelis Verhoef and Satish Warrier and Steven Wexner and {De Wilt}, Hans and Weinberg, {Benjamin A.} and Cameron Wells and Albert Wolthuis and Evangelos Xynos and Nancy You and Alexander Zakharenko and Justino Zeballos and Jonathan Zhou and Winter, {Des C.}",

year = "2022",

month = jul,

day = "1",

doi = "10.1093/bjs/znac108",

language = "English (US)",

volume = "109",

pages = "632--636",

journal = "British Journal of Surgery",

issn = "0007-1323",

publisher = "John Wiley and Sons Ltd",

number = "7",

}

TY - JOUR

T1 - Impact of microsatellite status in early-onset colonic cancer

AU - Zaborowski, Alexandra M.

AU - Adamina, Ahmed Abdile Michel

AU - Aigner, Felix

AU - D'Allens, Laura

AU - Allmer, Caterina

AU - Álvarez, Andrea

AU - Anula, Rocio

AU - Andric, Mihailo

AU - Bach, Sam Atallah Simon

AU - Bala, Miklosh

AU - Barussaud, Marie

AU - Bausys, Augustinas

AU - Beggs, Andrew

AU - Bellolio, Felipe

AU - Bennett, Melissa Rose

AU - Berdinskikh, Anton

AU - Bevan, Vicki

AU - Biondo, Sebastiano

AU - Bislenghi, Gabriele

AU - Bludau, Marc

AU - Brouwer, Nelleke

AU - Brown, Carl

AU - Bruns, Christiane

AU - Buchanan, Daniel D.

AU - Buchwald, Pamela

AU - Burger, Jacobus W.A.

AU - Burlov, Nikita

AU - Campanelli, Michela

AU - Capdepont, Maylis

AU - Carvello, Michele

AU - Chew, Hwee Hoon

AU - Christoforidis, Dimitri

AU - Clark, David

AU - Climent, Marta

AU - Collinson, Rowan

AU - Cologne, Kyle G.

AU - Contreras, Tomas

AU - Croner, Roland

AU - Daniels, Ian R.

AU - Dapri, Giovanni

AU - Davies, Justin

AU - Delrio, Paolo

AU - Denost, Quentin

AU - Deutsch, Michael

AU - Dias, Andre

AU - D'Hoore, Andre

AU - Drozdov, Evgeniy

AU - Duek, Daniel

AU - Dunlop, Malcolm

AU - Dziki, Adam

AU - Edmundson, Aleksandra

AU - Efetov, Sergey

AU - El-Hussuna, Alaa

AU - Elliot, Brodie

AU - Emile, Sameh

AU - Espin, Eloy

AU - Evans, Martyn

AU - Faes, Seraina

AU - Faiz, Omar

AU - Figueiredo, Nuno

AU - Fleming, Fergal

AU - Foppa, Caterina

AU - Fowler, George

AU - Frasson, Matteo

AU - Forgan, Tim

AU - Frizelle, Frank

AU - Gadaev, Shamil

AU - Gellona, Jose

AU - Glyn, Tamara

AU - Goran, Barisic

AU - Greenwood, Emma

AU - Guren, Marianne G.

AU - Guillon, Stephanie

AU - Gutlic, Ida

AU - Hahnloser, Dieter

AU - Hampel, Heather

AU - Hanly, Ann

AU - Hasegawa, Hirotoshi

AU - Iversen, Lene Hjerrild

AU - Hill, Andrew

AU - Hill, James

AU - Hoch, Jiri

AU - Hompes, Roel

AU - Hurtado, Luis

AU - Iaquinandi, Fabiano

AU - Imbrasaite, Ugne

AU - Islam, Rumana

AU - Jafari, Mehrenah D.

AU - Salido, Andrea Jimenez

AU - Jimenez-Toscano, Marta

AU - Kanemitsu, Yukihide

AU - Karachun, Aleksei

AU - Karimuddin, Ahmer A.

AU - Keller, Deborah S.

AU - Kelly, Justin

AU - Kennelly, Rory

AU - Khrykov, Gleb

AU - Kocian, Peter

AU - Koh, Cherry

AU - Kok, Neils

AU - Knight, Katrina A.

AU - Knol, Joep

AU - Kontovounisios, Christos

AU - Korner, Hartwig

AU - Krivokapic, Zoran

AU - Kronberger, Irmgard

AU - Kroon, Hidde Maarten

AU - Kryzauskas, Marius

AU - Kural, Said

AU - Kusters, Miranda

AU - Lakkis, Zaher

AU - Lankov, Timur

AU - Larson, David

AU - Lázár, György

AU - Lee, Kai Yin

AU - Lee, Suk Hwan

AU - Lefèvre, Jeremie H.

AU - Lepisto, Anna

AU - Lieu, Christopher

AU - Loi, Lynette

AU - Lynch, Craig

AU - Maillou-Martinaud, Helene

AU - Maroli, Annalisa

AU - Martin, Sean

AU - Martling, Anna

AU - Matzel, Klaus E.

AU - Mayol, Julio

AU - McDermott, Frank

AU - Meurette, Guillaume

AU - Millan, Monica

AU - Mitteregger, Martin

AU - Moiseenko, Andrei

AU - Monson, John R.T.

AU - Morarasu, Stefan

AU - Moritani, Konosuke

AU - Möslein, Gabriela

AU - Munini, Martino

AU - Nahas, Caio

AU - Nahas, Sergio

AU - Negoi, Ionut

AU - Novikova, Anastasia

AU - Ocares, Misael

AU - Okabayashi, Koji

AU - Olkina, Alexandra

AU - Oñate-Ocaña, Luis

AU - Otero, Jaime

AU - Ozen, Cihan

AU - Pace, Ugo

AU - Julião, Guilherme Pagin São

AU - Panaiotti, Lidiia

AU - Panis, Yves

AU - Papamichael, Demetris

AU - Patel, Swati

AU - Uriburu, Juan Carlos Patrón

AU - Peng, Sze Lin

AU - Pera, Miguel

AU - Perez, Rodrigo O.

AU - Petrov, Alexei

AU - Pfeffer, Frank

AU - Phang, Terry P.

AU - Poskus, Tomas

AU - Pringle, Heather

AU - Proud, David

AU - Raguz, Ivana

AU - Rama, Nuno

AU - Rasheed, Shahnawaz

AU - Raval, Manoj J.

AU - Rega, Daniela

AU - Reissfelder, Christoph

AU - Meneses, Juan Carlos Reyes

AU - Ris, Frederic

AU - Riss, Stefan

AU - Rodriguez-Zentner, Homero

AU - Roxburgh, Campbell S.

AU - Saklani, Avanish

AU - Sammour, Tarik

AU - Saraste, Deborah

AU - Schneider, Martin

AU - Seishima, Ryo

AU - Sekulic, Aleksandar

AU - Seppala, Toni

AU - Sheahan, Kieran

AU - Shlomina, Alexandra

AU - Sigismondo, Guiseppe

AU - Singnomklao, Tongplaew

AU - Siragusa, Leandro

AU - Smart, Neil

AU - Solis-Peña, Alejandro

AU - Spinelli, Antonino

AU - Staiger, Roxane D.

AU - Stamos, Michael J.

AU - Steele, Scott

AU - Tan, Ker Kan

AU - Tanis, Pieter J.

AU - Tekkis, Paris

AU - Teklay, Biniam

AU - Tengku, Sabrina

AU - Tsarkov, Petr

AU - Turina, Matthias

AU - Ulrich, Alexis

AU - Vailati, Bruna B.

AU - Van Harten, Meike

AU - Verhoef, Cornelis

AU - Warrier, Satish

AU - Wexner, Steven

AU - De Wilt, Hans

AU - Weinberg, Benjamin A.

AU - Wells, Cameron

AU - Wolthuis, Albert

AU - Xynos, Evangelos

AU - You, Nancy

AU - Zakharenko, Alexander

AU - Zeballos, Justino

AU - Zhou, Jonathan

AU - Winter, Des C.

PY - 2022/7/1

Y1 - 2022/7/1

N2 - Background: The molecular profile of early-onset colonic cancer is undefined. This study evaluated clinicopathological features and oncological outcomes of young patients with colonic cancer according to microsatellite status. Methods: Anonymized data from an international collaboration were analysed. Criteria for inclusion were patients younger than 50 years diagnosed with stage I-III colonic cancer that was surgically resected. Clinicopathological features, microsatellite status, and disease-specific outcomes were evaluated. Results: A total of 650 patients fulfilled the criteria for inclusion. Microsatellite instability (MSI) was identified in 170 (26.2 per cent), whereas 480 had microsatellite-stable (MSS) tumours (relative risk of MSI 2.5 compared with older patients). MSI was associated with a family history of colorectal cancer and lesions in the proximal colon. The proportions with pathological node-positive disease (45.9 versus 45.6 per cent; P = 1.000) and tumour budding (20.3 versus 20.5 per cent; P = 1.000) were similar in the two groups. Patients with MSI tumours were more likely to have BRAF (22.5 versus 6.9 per cent; P < 0.001) and KRAS (40.0 versus 24.2 per cent; P = 0.006) mutations, and a hereditary cancer syndrome (30.0 versus 5.0 per cent; P < 0.001; relative risk 6). Five-year disease-free survival rates in the MSI group were 95.0, 92.0, and 80.0 per cent for patients with stage I, II, and III tumours, compared with 88.0, 88.0, and 65.0 per cent in the MSS group (P = 0.753, P = 0.487, and P = 0.105 respectively). Conclusion: Patients with early-onset colonic cancer have a high risk of MSI and defined genetic conditions. Those with MSI tumours have more adverse pathology (budding, KRAS/BRAF mutations, and nodal metastases) than older patients with MSI cancers.

AB - Background: The molecular profile of early-onset colonic cancer is undefined. This study evaluated clinicopathological features and oncological outcomes of young patients with colonic cancer according to microsatellite status. Methods: Anonymized data from an international collaboration were analysed. Criteria for inclusion were patients younger than 50 years diagnosed with stage I-III colonic cancer that was surgically resected. Clinicopathological features, microsatellite status, and disease-specific outcomes were evaluated. Results: A total of 650 patients fulfilled the criteria for inclusion. Microsatellite instability (MSI) was identified in 170 (26.2 per cent), whereas 480 had microsatellite-stable (MSS) tumours (relative risk of MSI 2.5 compared with older patients). MSI was associated with a family history of colorectal cancer and lesions in the proximal colon. The proportions with pathological node-positive disease (45.9 versus 45.6 per cent; P = 1.000) and tumour budding (20.3 versus 20.5 per cent; P = 1.000) were similar in the two groups. Patients with MSI tumours were more likely to have BRAF (22.5 versus 6.9 per cent; P < 0.001) and KRAS (40.0 versus 24.2 per cent; P = 0.006) mutations, and a hereditary cancer syndrome (30.0 versus 5.0 per cent; P < 0.001; relative risk 6). Five-year disease-free survival rates in the MSI group were 95.0, 92.0, and 80.0 per cent for patients with stage I, II, and III tumours, compared with 88.0, 88.0, and 65.0 per cent in the MSS group (P = 0.753, P = 0.487, and P = 0.105 respectively). Conclusion: Patients with early-onset colonic cancer have a high risk of MSI and defined genetic conditions. Those with MSI tumours have more adverse pathology (budding, KRAS/BRAF mutations, and nodal metastases) than older patients with MSI cancers.

UR - http://www.scopus.com/inward/record.url?scp=85132452889&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85132452889&partnerID=8YFLogxK

U2 - 10.1093/bjs/znac108

DO - 10.1093/bjs/znac108

M3 - Article

C2 - 35522613

AN - SCOPUS:85132452889

SN - 0007-1323

VL - 109

SP - 632

EP - 636

JO - British Journal of Surgery

JF - British Journal of Surgery

IS - 7

ER -

Impact of microsatellite status in early-onset colonic cancer

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