Impact of metabolic syndrome on functional outcomes and complications of surgical treatment of prostate cancer

Alessandro Morlacco, Fabrizio Dal Moro, Laureano J. Rangel, Rachel E. Carlson, Matteo Soligo, Robert Jeffrey Karnes

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Background: Metabolic syndrome (MetS) has a negative impact on functional recovery and complications after many surgical procedures. Aim: To assess the role of Mets on functional outcomes and complications after radical prostatectomy (RP) for prostate cancer. Patients and Methods: Complete data were collected from 5758 patients, undergoing RP at a single referral centers in a 10-year period and the presence of MetS before surgery was ascertained in 17.7% of them using a modified version of the IDF-AHA/NHLBI criteria. Outcomes included 1-year continence and potency rates, early (≤90 days) and late (>90 days) complications. Results: Postoperative continence (no pads) was significantly less likely in MetS patients (75.4% vs 82.6%, P <.01), despite no difference in preoperative continence. Erections with or without therapy were reached in 55.8% of non-MetS and 41.8% of MetS patients (P <.01), in this case a significant difference in preoperative function was seen. No differences in early and late complications, except for wound infections (5.8% vs 3.9%, P <.01) were observed. Conclusions: In the present study RP was safe from the complications standpoint in MetS patients, but the presence of the syndrome was a significant risk factor for post-RP incontinence and impotence.

Original languageEnglish (US)
Pages (from-to)1505-1507
Number of pages3
JournalJournal of Surgical Oncology
Issue number8
StatePublished - Dec 1 2019


  • impotence
  • incontinence
  • metabolic syndrome
  • prostate cancer
  • surgical treatment

ASJC Scopus subject areas

  • Surgery
  • Oncology


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