Impact of incomplete revascularization on long-term mortality after coronary stenting

Chuntao Wu, Anne Marie Dyer, Spencer B. King, Gary Walford, David Holmes, Nicholas J. Stamato, Ferdinand J. Venditti, Samin K. Sharma, Icilma Fergus, Alice K. Jacobs, Edward L. Hannan

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background-The impact of incomplete revascularization (IR) on adverse outcomes after percutaneous coronary intervention remains inconclusive, and few studies have examined mortality during follow-ups longer than 5 years. The objective of this study is to test the hypothesis that IR is associated with higher risk of long-term (8-year) mortality after stenting for multivessel coronary disease. Methods and Results-A total of 13 016 patients with multivessel disease who had undergone stenting procedures with bare metal stents in 1999 to 2000 were identified in the New York State's Percutaneous Coronary Intervention Reporting System. A logistic regression model was fit to predict the probability of achieving complete revascularization (CR) in these patients using baseline risk factors; then, the CR patients were matched to the IR patients with similar likelihoods of achieving CR. Each patient's vital status was followed through 2007 using the National Death Index, and the difference in long-term mortality between IR and CR was compared. It was found that CR was achieved in 29.2% (3803) of the patients. For the 3803 pair-matched patients, the respective 8-year survival rates were 80.8% and 78.5% for CR and IR (P=0.04), respectively. The risk of death was marginally significantly higher for IR (hazard ratio=1.12; 95% confidence interval, 1.01-1.26, P=0.04). The 95% bootstrap confidence interval for the hazard ratio was 0.98 to 1.32. Conclusions-IR may be associated with higher risk of long-term mortality after stenting with BMS in patients with multivessel disease. More prospective studies are needed to further test this association.

Original languageEnglish (US)
Pages (from-to)413-421
Number of pages9
JournalCirculation: Cardiovascular Interventions
Volume4
Issue number5
DOIs
StatePublished - Oct 1 2011

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Mortality
Percutaneous Coronary Intervention
Logistic Models
Confidence Intervals
Stents
Coronary Disease
Survival Rate
Metals
Prospective Studies

Keywords

  • Coronary angioplasty
  • Coronary artery disease
  • Long-term follow-up
  • Mortality
  • Stenting

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Impact of incomplete revascularization on long-term mortality after coronary stenting. / Wu, Chuntao; Dyer, Anne Marie; King, Spencer B.; Walford, Gary; Holmes, David; Stamato, Nicholas J.; Venditti, Ferdinand J.; Sharma, Samin K.; Fergus, Icilma; Jacobs, Alice K.; Hannan, Edward L.

In: Circulation: Cardiovascular Interventions, Vol. 4, No. 5, 01.10.2011, p. 413-421.

Research output: Contribution to journalArticle

Wu, C, Dyer, AM, King, SB, Walford, G, Holmes, D, Stamato, NJ, Venditti, FJ, Sharma, SK, Fergus, I, Jacobs, AK & Hannan, EL 2011, 'Impact of incomplete revascularization on long-term mortality after coronary stenting', Circulation: Cardiovascular Interventions, vol. 4, no. 5, pp. 413-421. https://doi.org/10.1161/CIRCINTERVENTIONS.111.963058
Wu, Chuntao ; Dyer, Anne Marie ; King, Spencer B. ; Walford, Gary ; Holmes, David ; Stamato, Nicholas J. ; Venditti, Ferdinand J. ; Sharma, Samin K. ; Fergus, Icilma ; Jacobs, Alice K. ; Hannan, Edward L. / Impact of incomplete revascularization on long-term mortality after coronary stenting. In: Circulation: Cardiovascular Interventions. 2011 ; Vol. 4, No. 5. pp. 413-421.
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abstract = "Background-The impact of incomplete revascularization (IR) on adverse outcomes after percutaneous coronary intervention remains inconclusive, and few studies have examined mortality during follow-ups longer than 5 years. The objective of this study is to test the hypothesis that IR is associated with higher risk of long-term (8-year) mortality after stenting for multivessel coronary disease. Methods and Results-A total of 13 016 patients with multivessel disease who had undergone stenting procedures with bare metal stents in 1999 to 2000 were identified in the New York State's Percutaneous Coronary Intervention Reporting System. A logistic regression model was fit to predict the probability of achieving complete revascularization (CR) in these patients using baseline risk factors; then, the CR patients were matched to the IR patients with similar likelihoods of achieving CR. Each patient's vital status was followed through 2007 using the National Death Index, and the difference in long-term mortality between IR and CR was compared. It was found that CR was achieved in 29.2{\%} (3803) of the patients. For the 3803 pair-matched patients, the respective 8-year survival rates were 80.8{\%} and 78.5{\%} for CR and IR (P=0.04), respectively. The risk of death was marginally significantly higher for IR (hazard ratio=1.12; 95{\%} confidence interval, 1.01-1.26, P=0.04). The 95{\%} bootstrap confidence interval for the hazard ratio was 0.98 to 1.32. Conclusions-IR may be associated with higher risk of long-term mortality after stenting with BMS in patients with multivessel disease. More prospective studies are needed to further test this association.",
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T1 - Impact of incomplete revascularization on long-term mortality after coronary stenting

AU - Wu, Chuntao

AU - Dyer, Anne Marie

AU - King, Spencer B.

AU - Walford, Gary

AU - Holmes, David

AU - Stamato, Nicholas J.

AU - Venditti, Ferdinand J.

AU - Sharma, Samin K.

AU - Fergus, Icilma

AU - Jacobs, Alice K.

AU - Hannan, Edward L.

PY - 2011/10/1

Y1 - 2011/10/1

N2 - Background-The impact of incomplete revascularization (IR) on adverse outcomes after percutaneous coronary intervention remains inconclusive, and few studies have examined mortality during follow-ups longer than 5 years. The objective of this study is to test the hypothesis that IR is associated with higher risk of long-term (8-year) mortality after stenting for multivessel coronary disease. Methods and Results-A total of 13 016 patients with multivessel disease who had undergone stenting procedures with bare metal stents in 1999 to 2000 were identified in the New York State's Percutaneous Coronary Intervention Reporting System. A logistic regression model was fit to predict the probability of achieving complete revascularization (CR) in these patients using baseline risk factors; then, the CR patients were matched to the IR patients with similar likelihoods of achieving CR. Each patient's vital status was followed through 2007 using the National Death Index, and the difference in long-term mortality between IR and CR was compared. It was found that CR was achieved in 29.2% (3803) of the patients. For the 3803 pair-matched patients, the respective 8-year survival rates were 80.8% and 78.5% for CR and IR (P=0.04), respectively. The risk of death was marginally significantly higher for IR (hazard ratio=1.12; 95% confidence interval, 1.01-1.26, P=0.04). The 95% bootstrap confidence interval for the hazard ratio was 0.98 to 1.32. Conclusions-IR may be associated with higher risk of long-term mortality after stenting with BMS in patients with multivessel disease. More prospective studies are needed to further test this association.

AB - Background-The impact of incomplete revascularization (IR) on adverse outcomes after percutaneous coronary intervention remains inconclusive, and few studies have examined mortality during follow-ups longer than 5 years. The objective of this study is to test the hypothesis that IR is associated with higher risk of long-term (8-year) mortality after stenting for multivessel coronary disease. Methods and Results-A total of 13 016 patients with multivessel disease who had undergone stenting procedures with bare metal stents in 1999 to 2000 were identified in the New York State's Percutaneous Coronary Intervention Reporting System. A logistic regression model was fit to predict the probability of achieving complete revascularization (CR) in these patients using baseline risk factors; then, the CR patients were matched to the IR patients with similar likelihoods of achieving CR. Each patient's vital status was followed through 2007 using the National Death Index, and the difference in long-term mortality between IR and CR was compared. It was found that CR was achieved in 29.2% (3803) of the patients. For the 3803 pair-matched patients, the respective 8-year survival rates were 80.8% and 78.5% for CR and IR (P=0.04), respectively. The risk of death was marginally significantly higher for IR (hazard ratio=1.12; 95% confidence interval, 1.01-1.26, P=0.04). The 95% bootstrap confidence interval for the hazard ratio was 0.98 to 1.32. Conclusions-IR may be associated with higher risk of long-term mortality after stenting with BMS in patients with multivessel disease. More prospective studies are needed to further test this association.

KW - Coronary angioplasty

KW - Coronary artery disease

KW - Long-term follow-up

KW - Mortality

KW - Stenting

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