Impact of human papillomavirus vaccination on cervical cytology screening, colposcopy, and treatment

Ana Cecilia Rodríguez, Diane Solomon, Rolando Herrero, Allan Hildesheim, Paula González, Sholom Wacholder, Carolina Porras, Silvia Jiménez, Mark Schiffman, Mario Alfaro, Manuel Barrantes, M. Concepción Bratti, Fernando Cárdenas, Bernal Cortés, Albert Espinoza, Yenory Estrada, Silvia E. Jiménez, Jorge Morales, Luis Villegas, Lidia Ana MoreraElmer Pérez, Libia Rivas, Enrique Freer, José Bonilla, Alfonso García-Piñeres, Sandra Silva, Ivannia Atmella, Margarita Ramírez, Aimée R. Kreimer, Douglas R. Lowy, Nora Macklin, John T. Schiller, Mark E. Sherman, Ligia Pinto, Troy Kemp, Claire Eklund, Martha Hutchinson, Mary Sidawy, Wim Quint, Leen Jan Van Doorn

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The impact of human papillomavirus (HPV) vaccination on cervical screening, colposcopy, and treatment is incompletely understood. In 2004-2005, investigators in the Costa Rica Vaccine Trial randomized 7,466 women aged 18-25 years, 1:1, to receive HPV vaccination or hepatitis A vaccination. The worst-ever cytology diagnosis and the 4-year cumulative proportions of colposcopy referral and treatment by vaccination arm were compared for 2 cohorts. The total vaccinated cohort included 6,844 women who provided cervical samples. The naive cohort included 2,284 women with no evidence of previous HPV exposure. In the total vaccinated cohort, HPV-vaccinated women had a significant (P = 0.01) reduction in cytological abnormalities: 12.4% for high-grade lesions and 5.9% for minor lesions. Colposcopy referral was reduced by 7.9% (P = 0.03) and treatment by 11.3% (P = 0.24). Greater relative reductions in abnormal cytology (P < 0.001) were observed for HPV-vaccinated women in the naive cohort: 49.2% for high-grade lesions and 18.1% for minor lesions. Colposcopy referral and treatment were reduced by 21.3% (P = 0.01) and 45.6% (P = 0.08), respectively, in the naive cohort. The overall impact on health services will be modest in the first years after vaccine introduction among young adult women, even in regions with high coverage.

Original languageEnglish (US)
Pages (from-to)752-760
Number of pages9
JournalAmerican Journal of Epidemiology
Volume178
Issue number5
DOIs
StatePublished - Sep 1 2013

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Colposcopy
Cell Biology
Vaccination
Referral and Consultation
Therapeutics
Vaccines
Costa Rica
Hepatitis A
Health Services
Young Adult
Research Personnel

Keywords

  • cervical cancer
  • HPV
  • HPV vaccination
  • human papillomavirus
  • screening

ASJC Scopus subject areas

  • Epidemiology

Cite this

Rodríguez, A. C., Solomon, D., Herrero, R., Hildesheim, A., González, P., Wacholder, S., ... Van Doorn, L. J. (2013). Impact of human papillomavirus vaccination on cervical cytology screening, colposcopy, and treatment. American Journal of Epidemiology, 178(5), 752-760. https://doi.org/10.1093/aje/kwt047

Impact of human papillomavirus vaccination on cervical cytology screening, colposcopy, and treatment. / Rodríguez, Ana Cecilia; Solomon, Diane; Herrero, Rolando; Hildesheim, Allan; González, Paula; Wacholder, Sholom; Porras, Carolina; Jiménez, Silvia; Schiffman, Mark; Alfaro, Mario; Barrantes, Manuel; Bratti, M. Concepción; Cárdenas, Fernando; Cortés, Bernal; Espinoza, Albert; Estrada, Yenory; Jiménez, Silvia E.; Morales, Jorge; Villegas, Luis; Morera, Lidia Ana; Pérez, Elmer; Rivas, Libia; Freer, Enrique; Bonilla, José; García-Piñeres, Alfonso; Silva, Sandra; Atmella, Ivannia; Ramírez, Margarita; Kreimer, Aimée R.; Lowy, Douglas R.; Macklin, Nora; Schiller, John T.; Sherman, Mark E.; Pinto, Ligia; Kemp, Troy; Eklund, Claire; Hutchinson, Martha; Sidawy, Mary; Quint, Wim; Van Doorn, Leen Jan.

In: American Journal of Epidemiology, Vol. 178, No. 5, 01.09.2013, p. 752-760.

Research output: Contribution to journalArticle

Rodríguez, AC, Solomon, D, Herrero, R, Hildesheim, A, González, P, Wacholder, S, Porras, C, Jiménez, S, Schiffman, M, Alfaro, M, Barrantes, M, Bratti, MC, Cárdenas, F, Cortés, B, Espinoza, A, Estrada, Y, Jiménez, SE, Morales, J, Villegas, L, Morera, LA, Pérez, E, Rivas, L, Freer, E, Bonilla, J, García-Piñeres, A, Silva, S, Atmella, I, Ramírez, M, Kreimer, AR, Lowy, DR, Macklin, N, Schiller, JT, Sherman, ME, Pinto, L, Kemp, T, Eklund, C, Hutchinson, M, Sidawy, M, Quint, W & Van Doorn, LJ 2013, 'Impact of human papillomavirus vaccination on cervical cytology screening, colposcopy, and treatment', American Journal of Epidemiology, vol. 178, no. 5, pp. 752-760. https://doi.org/10.1093/aje/kwt047
Rodríguez AC, Solomon D, Herrero R, Hildesheim A, González P, Wacholder S et al. Impact of human papillomavirus vaccination on cervical cytology screening, colposcopy, and treatment. American Journal of Epidemiology. 2013 Sep 1;178(5):752-760. https://doi.org/10.1093/aje/kwt047
Rodríguez, Ana Cecilia ; Solomon, Diane ; Herrero, Rolando ; Hildesheim, Allan ; González, Paula ; Wacholder, Sholom ; Porras, Carolina ; Jiménez, Silvia ; Schiffman, Mark ; Alfaro, Mario ; Barrantes, Manuel ; Bratti, M. Concepción ; Cárdenas, Fernando ; Cortés, Bernal ; Espinoza, Albert ; Estrada, Yenory ; Jiménez, Silvia E. ; Morales, Jorge ; Villegas, Luis ; Morera, Lidia Ana ; Pérez, Elmer ; Rivas, Libia ; Freer, Enrique ; Bonilla, José ; García-Piñeres, Alfonso ; Silva, Sandra ; Atmella, Ivannia ; Ramírez, Margarita ; Kreimer, Aimée R. ; Lowy, Douglas R. ; Macklin, Nora ; Schiller, John T. ; Sherman, Mark E. ; Pinto, Ligia ; Kemp, Troy ; Eklund, Claire ; Hutchinson, Martha ; Sidawy, Mary ; Quint, Wim ; Van Doorn, Leen Jan. / Impact of human papillomavirus vaccination on cervical cytology screening, colposcopy, and treatment. In: American Journal of Epidemiology. 2013 ; Vol. 178, No. 5. pp. 752-760.
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abstract = "The impact of human papillomavirus (HPV) vaccination on cervical screening, colposcopy, and treatment is incompletely understood. In 2004-2005, investigators in the Costa Rica Vaccine Trial randomized 7,466 women aged 18-25 years, 1:1, to receive HPV vaccination or hepatitis A vaccination. The worst-ever cytology diagnosis and the 4-year cumulative proportions of colposcopy referral and treatment by vaccination arm were compared for 2 cohorts. The total vaccinated cohort included 6,844 women who provided cervical samples. The naive cohort included 2,284 women with no evidence of previous HPV exposure. In the total vaccinated cohort, HPV-vaccinated women had a significant (P = 0.01) reduction in cytological abnormalities: 12.4{\%} for high-grade lesions and 5.9{\%} for minor lesions. Colposcopy referral was reduced by 7.9{\%} (P = 0.03) and treatment by 11.3{\%} (P = 0.24). Greater relative reductions in abnormal cytology (P < 0.001) were observed for HPV-vaccinated women in the naive cohort: 49.2{\%} for high-grade lesions and 18.1{\%} for minor lesions. Colposcopy referral and treatment were reduced by 21.3{\%} (P = 0.01) and 45.6{\%} (P = 0.08), respectively, in the naive cohort. The overall impact on health services will be modest in the first years after vaccine introduction among young adult women, even in regions with high coverage.",
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AU - Wacholder, Sholom

AU - Porras, Carolina

AU - Jiménez, Silvia

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AU - Alfaro, Mario

AU - Barrantes, Manuel

AU - Bratti, M. Concepción

AU - Cárdenas, Fernando

AU - Cortés, Bernal

AU - Espinoza, Albert

AU - Estrada, Yenory

AU - Jiménez, Silvia E.

AU - Morales, Jorge

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AU - Morera, Lidia Ana

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AU - Rivas, Libia

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AU - García-Piñeres, Alfonso

AU - Silva, Sandra

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AU - Kreimer, Aimée R.

AU - Lowy, Douglas R.

AU - Macklin, Nora

AU - Schiller, John T.

AU - Sherman, Mark E.

AU - Pinto, Ligia

AU - Kemp, Troy

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