Impact of genomic damage and ageing on stem cell function

Axel Behrens, Jan M. Van Deursen, K. Lenhard Rudolph, Björn Schumacher

Research output: Contribution to journalReview article

107 Scopus citations

Abstract

Impairment of stem cell function contributes to the progressive deterioration of tissue maintenance and repair with ageing. Evidence is mounting that age-dependent accumulation of DNA damage in both stem cells and cells that comprise the stem cell microenvironment are partly responsible for stem cell dysfunction with ageing. Here, we review the impact of the various types of DNA damage that accumulate with ageing on stem cell functionality, as well as the development of cancer. We discuss DNA-damage-induced cell intrinsic and extrinsic alterations that influence these processes, and review recent advances in understanding systemic adjustments to DNA damage and how they affect stem cells.

Original languageEnglish (US)
Pages (from-to)201-207
Number of pages7
JournalNature Cell Biology
Volume16
Issue number3
DOIs
StatePublished - Mar 2014

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ASJC Scopus subject areas

  • Cell Biology

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