Impact of genomic damage and ageing on stem cell function

Axel Behrens; Jan M. Van Deursen; K. Lenhard Rudolph; Björn Schumacher

doi:10.1038/ncb2928

Impact of genomic damage and ageing on stem cell function

Axel Behrens, Jan M. Van Deursen, K. Lenhard Rudolph, Björn Schumacher

Pediatric and Adolescent Medicine

Research output: Contribution to journal › Review article › peer-review

125 Scopus citations

Abstract

Impairment of stem cell function contributes to the progressive deterioration of tissue maintenance and repair with ageing. Evidence is mounting that age-dependent accumulation of DNA damage in both stem cells and cells that comprise the stem cell microenvironment are partly responsible for stem cell dysfunction with ageing. Here, we review the impact of the various types of DNA damage that accumulate with ageing on stem cell functionality, as well as the development of cancer. We discuss DNA-damage-induced cell intrinsic and extrinsic alterations that influence these processes, and review recent advances in understanding systemic adjustments to DNA damage and how they affect stem cells.

Original language	English (US)
Pages (from-to)	201-207
Number of pages	7
Journal	Nature Cell Biology
Volume	16
Issue number	3
DOIs	https://doi.org/10.1038/ncb2928
State	Published - Mar 2014

ASJC Scopus subject areas

Cell Biology

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10.1038/ncb2928

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title = "Impact of genomic damage and ageing on stem cell function",

abstract = "Impairment of stem cell function contributes to the progressive deterioration of tissue maintenance and repair with ageing. Evidence is mounting that age-dependent accumulation of DNA damage in both stem cells and cells that comprise the stem cell microenvironment are partly responsible for stem cell dysfunction with ageing. Here, we review the impact of the various types of DNA damage that accumulate with ageing on stem cell functionality, as well as the development of cancer. We discuss DNA-damage-induced cell intrinsic and extrinsic alterations that influence these processes, and review recent advances in understanding systemic adjustments to DNA damage and how they affect stem cells.",

author = "Axel Behrens and {Van Deursen}, {Jan M.} and Rudolph, {K. Lenhard} and Bj{\"o}rn Schumacher",

note = "Funding Information: We thank the Else Kr{\"o}ner-Fresenius-Foundation for funding the 5th Else Kr{\"o}ner-Fresenius-Symposium in Molecular Medicine on the {\textquoteleft}Role of Stem Cells in Aging, Diseases, and Cancer{\textquoteright}. This meeting fostered the discussion on DNA damage in stem cells and was the basis of this Review. We apologize to our colleagues for omitting numerous references due to space limitations.",

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N2 - Impairment of stem cell function contributes to the progressive deterioration of tissue maintenance and repair with ageing. Evidence is mounting that age-dependent accumulation of DNA damage in both stem cells and cells that comprise the stem cell microenvironment are partly responsible for stem cell dysfunction with ageing. Here, we review the impact of the various types of DNA damage that accumulate with ageing on stem cell functionality, as well as the development of cancer. We discuss DNA-damage-induced cell intrinsic and extrinsic alterations that influence these processes, and review recent advances in understanding systemic adjustments to DNA damage and how they affect stem cells.

AB - Impairment of stem cell function contributes to the progressive deterioration of tissue maintenance and repair with ageing. Evidence is mounting that age-dependent accumulation of DNA damage in both stem cells and cells that comprise the stem cell microenvironment are partly responsible for stem cell dysfunction with ageing. Here, we review the impact of the various types of DNA damage that accumulate with ageing on stem cell functionality, as well as the development of cancer. We discuss DNA-damage-induced cell intrinsic and extrinsic alterations that influence these processes, and review recent advances in understanding systemic adjustments to DNA damage and how they affect stem cells.

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Impact of genomic damage and ageing on stem cell function

Abstract

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