Impact of gender on the outcome of endovascular aortic aneurysm repair using the zenith stent-graft: Midterm results

Beate Hugl, Albert Hakaim, Matthias Biebl, W. Andrew Oldenburg, J. Mark McKinney, Lorraine A. Nolte, Roy K. Greenberg, Timothy A M Chuter

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Purpose: To analyze the 2-year outcomes of female patients after endovascular aortic aneurysm repair (EVAR) with the Zenith AAA Endovascular Graft. Methods: A retrospective analysis was conducted of data from the US Zenith multicenter trial and the Zenith female registry on 40 women (10.9%, study group) and 326 men (89.1%, control group) enrolled. All patients had completed their 2-year follow-up. Primary study endpoints were survival, aneurysm rupture, and conversion rate. Significance was assumed if p<0.05. Results: Overall rates of mortality (12.5% for women versus 13.2% for men, p=0.94) and aneurysm rupture (2.5% for women versus 0% for men, p=0.11) were comparable between groups. Conversion to open repair within 2 years was significantly more frequent in women compared to men (7.5% versus 0.6%, p=0.01). The incidence of endoleaks of any type was equivalent between groups at 2 years (13.3% for women versus 6.9% for men, p=0.30). No difference was observed in the need for secondary interventions (15% for women versus 13.5% for men, p=0.81) or aneurysm dilatation >5 mm (10.5% for women versus 2.3% for men, p=0.10). None of the patients developed device migration >10 mm or required intervention for migration. Conclusion: While women underwent conversion to open repair more frequently compared to men at 2 years post EVAR, there was no difference in survival, freedom from aneurysm rupture, or need for secondary interventions between groups. As in men, the Zenith AAA Endovascular Graft provides reliable protection from aneurysm rupture and aneurysm-related death in women in a midterm follow-up.

Original languageEnglish (US)
Pages (from-to)115-121
Number of pages7
JournalJournal of Endovascular Therapy
Volume14
Issue number2
DOIs
StatePublished - Apr 2007

Fingerprint

Aortic Aneurysm
Stents
Aneurysm
Transplants
Rupture
Survival
Multicenter Studies
Registries
Equipment and Supplies
Control Groups

Keywords

  • Abdominal aortic aneurysm
  • Aneurysm rupture
  • Conversion
  • Endovascular repair
  • Female gender
  • Gender-specific outcomes
  • Mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Impact of gender on the outcome of endovascular aortic aneurysm repair using the zenith stent-graft : Midterm results. / Hugl, Beate; Hakaim, Albert; Biebl, Matthias; Oldenburg, W. Andrew; McKinney, J. Mark; Nolte, Lorraine A.; Greenberg, Roy K.; Chuter, Timothy A M.

In: Journal of Endovascular Therapy, Vol. 14, No. 2, 04.2007, p. 115-121.

Research output: Contribution to journalArticle

Hugl, Beate ; Hakaim, Albert ; Biebl, Matthias ; Oldenburg, W. Andrew ; McKinney, J. Mark ; Nolte, Lorraine A. ; Greenberg, Roy K. ; Chuter, Timothy A M. / Impact of gender on the outcome of endovascular aortic aneurysm repair using the zenith stent-graft : Midterm results. In: Journal of Endovascular Therapy. 2007 ; Vol. 14, No. 2. pp. 115-121.
@article{ab44304d121644719bf5b319a54bfc64,
title = "Impact of gender on the outcome of endovascular aortic aneurysm repair using the zenith stent-graft: Midterm results",
abstract = "Purpose: To analyze the 2-year outcomes of female patients after endovascular aortic aneurysm repair (EVAR) with the Zenith AAA Endovascular Graft. Methods: A retrospective analysis was conducted of data from the US Zenith multicenter trial and the Zenith female registry on 40 women (10.9{\%}, study group) and 326 men (89.1{\%}, control group) enrolled. All patients had completed their 2-year follow-up. Primary study endpoints were survival, aneurysm rupture, and conversion rate. Significance was assumed if p<0.05. Results: Overall rates of mortality (12.5{\%} for women versus 13.2{\%} for men, p=0.94) and aneurysm rupture (2.5{\%} for women versus 0{\%} for men, p=0.11) were comparable between groups. Conversion to open repair within 2 years was significantly more frequent in women compared to men (7.5{\%} versus 0.6{\%}, p=0.01). The incidence of endoleaks of any type was equivalent between groups at 2 years (13.3{\%} for women versus 6.9{\%} for men, p=0.30). No difference was observed in the need for secondary interventions (15{\%} for women versus 13.5{\%} for men, p=0.81) or aneurysm dilatation >5 mm (10.5{\%} for women versus 2.3{\%} for men, p=0.10). None of the patients developed device migration >10 mm or required intervention for migration. Conclusion: While women underwent conversion to open repair more frequently compared to men at 2 years post EVAR, there was no difference in survival, freedom from aneurysm rupture, or need for secondary interventions between groups. As in men, the Zenith AAA Endovascular Graft provides reliable protection from aneurysm rupture and aneurysm-related death in women in a midterm follow-up.",
keywords = "Abdominal aortic aneurysm, Aneurysm rupture, Conversion, Endovascular repair, Female gender, Gender-specific outcomes, Mortality",
author = "Beate Hugl and Albert Hakaim and Matthias Biebl and Oldenburg, {W. Andrew} and McKinney, {J. Mark} and Nolte, {Lorraine A.} and Greenberg, {Roy K.} and Chuter, {Timothy A M}",
year = "2007",
month = "4",
doi = "10.1583/1545-1550(2007)14[115:IOGOTO]2.0.CO;2",
language = "English (US)",
volume = "14",
pages = "115--121",
journal = "Journal of Endovascular Therapy",
issn = "1526-6028",
publisher = "International Society of Endovascular Specialists",
number = "2",

}

TY - JOUR

T1 - Impact of gender on the outcome of endovascular aortic aneurysm repair using the zenith stent-graft

T2 - Midterm results

AU - Hugl, Beate

AU - Hakaim, Albert

AU - Biebl, Matthias

AU - Oldenburg, W. Andrew

AU - McKinney, J. Mark

AU - Nolte, Lorraine A.

AU - Greenberg, Roy K.

AU - Chuter, Timothy A M

PY - 2007/4

Y1 - 2007/4

N2 - Purpose: To analyze the 2-year outcomes of female patients after endovascular aortic aneurysm repair (EVAR) with the Zenith AAA Endovascular Graft. Methods: A retrospective analysis was conducted of data from the US Zenith multicenter trial and the Zenith female registry on 40 women (10.9%, study group) and 326 men (89.1%, control group) enrolled. All patients had completed their 2-year follow-up. Primary study endpoints were survival, aneurysm rupture, and conversion rate. Significance was assumed if p<0.05. Results: Overall rates of mortality (12.5% for women versus 13.2% for men, p=0.94) and aneurysm rupture (2.5% for women versus 0% for men, p=0.11) were comparable between groups. Conversion to open repair within 2 years was significantly more frequent in women compared to men (7.5% versus 0.6%, p=0.01). The incidence of endoleaks of any type was equivalent between groups at 2 years (13.3% for women versus 6.9% for men, p=0.30). No difference was observed in the need for secondary interventions (15% for women versus 13.5% for men, p=0.81) or aneurysm dilatation >5 mm (10.5% for women versus 2.3% for men, p=0.10). None of the patients developed device migration >10 mm or required intervention for migration. Conclusion: While women underwent conversion to open repair more frequently compared to men at 2 years post EVAR, there was no difference in survival, freedom from aneurysm rupture, or need for secondary interventions between groups. As in men, the Zenith AAA Endovascular Graft provides reliable protection from aneurysm rupture and aneurysm-related death in women in a midterm follow-up.

AB - Purpose: To analyze the 2-year outcomes of female patients after endovascular aortic aneurysm repair (EVAR) with the Zenith AAA Endovascular Graft. Methods: A retrospective analysis was conducted of data from the US Zenith multicenter trial and the Zenith female registry on 40 women (10.9%, study group) and 326 men (89.1%, control group) enrolled. All patients had completed their 2-year follow-up. Primary study endpoints were survival, aneurysm rupture, and conversion rate. Significance was assumed if p<0.05. Results: Overall rates of mortality (12.5% for women versus 13.2% for men, p=0.94) and aneurysm rupture (2.5% for women versus 0% for men, p=0.11) were comparable between groups. Conversion to open repair within 2 years was significantly more frequent in women compared to men (7.5% versus 0.6%, p=0.01). The incidence of endoleaks of any type was equivalent between groups at 2 years (13.3% for women versus 6.9% for men, p=0.30). No difference was observed in the need for secondary interventions (15% for women versus 13.5% for men, p=0.81) or aneurysm dilatation >5 mm (10.5% for women versus 2.3% for men, p=0.10). None of the patients developed device migration >10 mm or required intervention for migration. Conclusion: While women underwent conversion to open repair more frequently compared to men at 2 years post EVAR, there was no difference in survival, freedom from aneurysm rupture, or need for secondary interventions between groups. As in men, the Zenith AAA Endovascular Graft provides reliable protection from aneurysm rupture and aneurysm-related death in women in a midterm follow-up.

KW - Abdominal aortic aneurysm

KW - Aneurysm rupture

KW - Conversion

KW - Endovascular repair

KW - Female gender

KW - Gender-specific outcomes

KW - Mortality

UR - http://www.scopus.com/inward/record.url?scp=34248668749&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34248668749&partnerID=8YFLogxK

U2 - 10.1583/1545-1550(2007)14[115:IOGOTO]2.0.CO;2

DO - 10.1583/1545-1550(2007)14[115:IOGOTO]2.0.CO;2

M3 - Article

C2 - 17484525

AN - SCOPUS:34248668749

VL - 14

SP - 115

EP - 121

JO - Journal of Endovascular Therapy

JF - Journal of Endovascular Therapy

SN - 1526-6028

IS - 2

ER -