Impact of family structure on the power of linkage tests using sib-pair methods

Katrina A.B. Goddard, Ellen L. Goode, Laura S. Rozek, Gall P. Jarvik

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

This analysis sought to determine the impact of specific ascertainment criteria based upon nuclear family affectation structures. Specifically, we evaluated the predicted and observed proportion of alleles shared identical by descent conditional on the number of affected and unaffected siblings in a pedigree, and compared sib-pair method linkage results under two ascertainment schemes, random vs. selected ascertainment, for this simulated complex genetic disease. These results suggest that samples differing in the composition of affected and unaffected siblings in the family will differ in their power to detect linkage. An effect of sampling scheme on power to map using affected-sib-pair methods should be considered when a reported linkage is not found in another study population.

Original languageEnglish (US)
Pages (from-to)S575-S579
JournalGenetic epidemiology
Volume17
Issue numberSUPPL. 1
DOIs
StatePublished - Jan 1 1999

Keywords

  • Ascertainment
  • Means test

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)

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