Impact of ethnicity on left ventricular mass and relative wall thickness in essential hypertension

Miguel Zabalgoitia, S. Noor Ur Rahman, William E Haley, Lori Oneschuk, Carla Yunis, Charles Lucas, Steven Yarows, Lisa Krause, John Amerena

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

This study was designed to evaluate the impact of ethnicity on left ventricular (LV) mass, and relative wall thickness in 527 patients (57% men, mean age 60 ± 7 years) with mild to moderate high blood pressure. There were 63% Caucasians, 21% African-Americans, and 16% Hispanics. LV mass was indexed according to body surface area, height, and height to the allometric power of 2.7. Relative wall thickness included the 4 widely recognized patterns: normal, concentric remodeling, eccentric hypertrophy, and concentric hypertrophy. LV mass indexed to body surface area was similar among all 3 ethnic groups (Caucasians 117.1 g/m2, African-Americans 119.2 g/m2, Hispanics 122.7 g/m2); however, when indexed to height and height to the power of 2.7, Hispanics had slightly larger masses than the other 2 groups (Hispanics 168.1 and 73.3 g/m2.7 vs Caucasians 159.8 and 64.4 g/m2.7 [p = NS and p <0.005]; and vs African-Americans 164.8 and 69.2 g/m2.7 [p = NS for both]). Using body surface area, the concentric remodeling was the predominant form of cardiac adaptation in Caucasians (36%) and African- Americans (42%), whereas the concentric hypertrophy pattern was 38% in Hispanics. Using indexing for both height and height to the power of 2.7, the concentric hypertrophy pattern predominated in all 3 ethnic groups (Caucasians 48% and 51%; African-Americans 68% and 66%; Hispanics 59% and 65%). In conclusion, because of the independent impact of weight on high blood pressure, LV mass adjusted to height or to height at the power of 2.7 should be reported in population studies. The concentric hypertrophy pattern - classic LV response to pressure overload conditions - is better represented when LV mass is indexed to height or to height to the allometric power of 2.7 than to body surface area.

Original languageEnglish (US)
Pages (from-to)412-417
Number of pages6
JournalAmerican Journal of Cardiology
Volume81
Issue number4
DOIs
StatePublished - Feb 15 1998

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Hispanic Americans
African Americans
Hypertrophy
Body Surface Area
Ethnic Groups
Hypertension
Essential Hypertension
Pressure
Weights and Measures
Population

ASJC Scopus subject areas

  • Medicine(all)
  • Cardiology and Cardiovascular Medicine

Cite this

Impact of ethnicity on left ventricular mass and relative wall thickness in essential hypertension. / Zabalgoitia, Miguel; Ur Rahman, S. Noor; Haley, William E; Oneschuk, Lori; Yunis, Carla; Lucas, Charles; Yarows, Steven; Krause, Lisa; Amerena, John.

In: American Journal of Cardiology, Vol. 81, No. 4, 15.02.1998, p. 412-417.

Research output: Contribution to journalArticle

Zabalgoitia, M, Ur Rahman, SN, Haley, WE, Oneschuk, L, Yunis, C, Lucas, C, Yarows, S, Krause, L & Amerena, J 1998, 'Impact of ethnicity on left ventricular mass and relative wall thickness in essential hypertension', American Journal of Cardiology, vol. 81, no. 4, pp. 412-417. https://doi.org/10.1016/S0002-9149(97)00925-9
Zabalgoitia, Miguel ; Ur Rahman, S. Noor ; Haley, William E ; Oneschuk, Lori ; Yunis, Carla ; Lucas, Charles ; Yarows, Steven ; Krause, Lisa ; Amerena, John. / Impact of ethnicity on left ventricular mass and relative wall thickness in essential hypertension. In: American Journal of Cardiology. 1998 ; Vol. 81, No. 4. pp. 412-417.
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abstract = "This study was designed to evaluate the impact of ethnicity on left ventricular (LV) mass, and relative wall thickness in 527 patients (57{\%} men, mean age 60 ± 7 years) with mild to moderate high blood pressure. There were 63{\%} Caucasians, 21{\%} African-Americans, and 16{\%} Hispanics. LV mass was indexed according to body surface area, height, and height to the allometric power of 2.7. Relative wall thickness included the 4 widely recognized patterns: normal, concentric remodeling, eccentric hypertrophy, and concentric hypertrophy. LV mass indexed to body surface area was similar among all 3 ethnic groups (Caucasians 117.1 g/m2, African-Americans 119.2 g/m2, Hispanics 122.7 g/m2); however, when indexed to height and height to the power of 2.7, Hispanics had slightly larger masses than the other 2 groups (Hispanics 168.1 and 73.3 g/m2.7 vs Caucasians 159.8 and 64.4 g/m2.7 [p = NS and p <0.005]; and vs African-Americans 164.8 and 69.2 g/m2.7 [p = NS for both]). Using body surface area, the concentric remodeling was the predominant form of cardiac adaptation in Caucasians (36{\%}) and African- Americans (42{\%}), whereas the concentric hypertrophy pattern was 38{\%} in Hispanics. Using indexing for both height and height to the power of 2.7, the concentric hypertrophy pattern predominated in all 3 ethnic groups (Caucasians 48{\%} and 51{\%}; African-Americans 68{\%} and 66{\%}; Hispanics 59{\%} and 65{\%}). In conclusion, because of the independent impact of weight on high blood pressure, LV mass adjusted to height or to height at the power of 2.7 should be reported in population studies. The concentric hypertrophy pattern - classic LV response to pressure overload conditions - is better represented when LV mass is indexed to height or to height to the allometric power of 2.7 than to body surface area.",
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