Impact of Donor Spontaneous Intracranial Hemorrhage on Outcome after Heart Transplantation

Mohamad H. Yamani, Michael S. Lauer, Randall C. Starling, Claire E. Pothier, E. Murat Tuzcu, Norman B. Ratliff, Daniel J. Cook, Ashraf Abdo, Ann McNeil, Tim Crowe, Robert Hobbs, Gustavo Rincon, Corinne Bott-Silverman, Patrick M. McCarthy, James B. Young

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Donor cause of death has been suggested to have a significant impact on cardiac transplant morbidity and mortality. Our objective was to evaluate the impact of donor spontaneous intracranial bleeding on clinical outcome after heart transplantation. A group of 160 recipients underwent cardiac transplantation from donors with spontaneous intracranial bleeding (ICB group). These were compared with 197 recipients who were transplanted from trauma donors (Trauma group). A higher 4-year mortality rate was noted in the ICB group (24% vs. 14%, p = 0.015). ICB as a cause of donor death was an independent predictor of recipient mortality (adjusted hazard ratio 2.02, 95% CI 1.27-3.40, p < 0.0001). Compared with the Trauma group, the ICB group had an increased incidence of post-transplant graft dysfunction during the first week of transplant (10% vs. 3%, p = 0.007), and higher incidence of interstitial myocardial fibrosis on their endomyocardial biopsies within 4 weeks of transplant (21% vs. 9%, p = 0.0012). There was a trend towards an increased rate of allograft vasculopathy in the ICB group (competing risks adjusted hazard ratio 1.39, 95% CI 0.90-2.13, p = 0.14).

Original languageEnglish (US)
Pages (from-to)257-261
Number of pages5
JournalAmerican Journal of Transplantation
Volume4
Issue number2
DOIs
StatePublished - Feb 2004
Externally publishedYes

Fingerprint

Intracranial Hemorrhages
Heart Transplantation
Transplants
Mortality
Cause of Death
Wounds and Injuries
Hemorrhage
Incidence
Allografts
Fibrosis
Morbidity
Biopsy

Keywords

  • Allograft vasculopathy
  • Heart transplantation
  • Intracranial bleeding

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

Cite this

Yamani, M. H., Lauer, M. S., Starling, R. C., Pothier, C. E., Tuzcu, E. M., Ratliff, N. B., ... Young, J. B. (2004). Impact of Donor Spontaneous Intracranial Hemorrhage on Outcome after Heart Transplantation. American Journal of Transplantation, 4(2), 257-261. https://doi.org/10.1046/j.1600-6143.2003.00314.x

Impact of Donor Spontaneous Intracranial Hemorrhage on Outcome after Heart Transplantation. / Yamani, Mohamad H.; Lauer, Michael S.; Starling, Randall C.; Pothier, Claire E.; Tuzcu, E. Murat; Ratliff, Norman B.; Cook, Daniel J.; Abdo, Ashraf; McNeil, Ann; Crowe, Tim; Hobbs, Robert; Rincon, Gustavo; Bott-Silverman, Corinne; McCarthy, Patrick M.; Young, James B.

In: American Journal of Transplantation, Vol. 4, No. 2, 02.2004, p. 257-261.

Research output: Contribution to journalArticle

Yamani, MH, Lauer, MS, Starling, RC, Pothier, CE, Tuzcu, EM, Ratliff, NB, Cook, DJ, Abdo, A, McNeil, A, Crowe, T, Hobbs, R, Rincon, G, Bott-Silverman, C, McCarthy, PM & Young, JB 2004, 'Impact of Donor Spontaneous Intracranial Hemorrhage on Outcome after Heart Transplantation', American Journal of Transplantation, vol. 4, no. 2, pp. 257-261. https://doi.org/10.1046/j.1600-6143.2003.00314.x
Yamani, Mohamad H. ; Lauer, Michael S. ; Starling, Randall C. ; Pothier, Claire E. ; Tuzcu, E. Murat ; Ratliff, Norman B. ; Cook, Daniel J. ; Abdo, Ashraf ; McNeil, Ann ; Crowe, Tim ; Hobbs, Robert ; Rincon, Gustavo ; Bott-Silverman, Corinne ; McCarthy, Patrick M. ; Young, James B. / Impact of Donor Spontaneous Intracranial Hemorrhage on Outcome after Heart Transplantation. In: American Journal of Transplantation. 2004 ; Vol. 4, No. 2. pp. 257-261.
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