Impact of chronic changes in arterial compliance and resistance on left ventricular ageing in humans

Peter Wohlfahrt, Margaret M. Redfield, Vojtech Melenovsky, Francisco Lopez-Jimenez, Richard J. Rodeheffer, Barry A. Borlaug

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Aims: Left ventricular systolic elastance (Ees) and diastolic elastance (Eed) correlate with arterial elastance (Ea), but it is unknown how chronic changes in arterial compliance and resistance, which determine Ea, might differentially affect cardiac properties with ageing. We sought to characterize chronic changes in pulsatile and resistive arterial load and correlate them with longitudinal changes in LV structure and function in a prospective, community-based study. Methods and results: Comprehensive echocardiography was performed in 722 subjects participating in a randomly selected community-based study at two examinations separated by 4 years, allowing for assessment of LV Ees, Eed, and end-diastolic volume (EDV), Ea, total arterial compliance, and systemic vascular resistance at both examinations. Chronic changes in resistance and heart rate were the dominant contributors to change in Ea. Changes in arterial compliance had little impact on changes in Ea, but were strongly associated with changes in Ees. The combination of increased resistance and decreased compliance was associated with the largest increase in LV diastolic stiffness, an effect that was mediated by a decrease in LVEDV. In contrast, subjects with both improved arterial compliance and decreased resistance displayed an increase in LVEDV over time, with no increase in LV Eed. Conclusion: Increases in pulsatile arterial load with ageing contribute more to LV systolic stiffening, while combined pulsatile and resistive loading changes are associated with positive and negative chamber remodelling and diastolic stiffness. Therapies designed to improve arterial resistance and particularly to enhance aortic compliance may hold promise to prevent or reverse cardiac ageing and its sequelae.

Original languageEnglish (US)
Pages (from-to)27-34
Number of pages8
JournalEuropean Journal of Heart Failure
Volume17
Issue number1
DOIs
StatePublished - Jan 1 2015

Keywords

  • Ageing
  • Arterial compliance
  • Arterial resistance
  • Heart failure
  • Heart failure with preserved ejection fraction
  • Left ventricular stiffness

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Impact of chronic changes in arterial compliance and resistance on left ventricular ageing in humans'. Together they form a unique fingerprint.

  • Cite this