Impact of Cervical Dystonia on Work Productivity: An Analysis From a Patient Registry

Eric S. Molho, Mark Stacy, Patrick Gillard, David Charles, Charles Howard Adler, Joseph Jankovic, Marc Schwartz, Mitchell F. Brin

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Cervical dystonia is thought to result in high disease burden, but limited information exists on its impact on employment and work productivity. We utilized data from the Cervical Dystonia Patient Registry for the Observation of OnabotulinumtoxinA Efficacy (ClinicalTrials.gov identifier: NCT00836017) to assess the impact of cervical dystonia on employment and work productivity and examine the effect of onabotulinumtoxinA treatments on work productivity. Methods: Subjects completed a questionnaire on employment status and work productivity at baseline and final visit. Baseline data were examined by severity of cervical dystonia, predominant subtype, presence of pain, prior exposure to botulinum toxin, and/or utility of a sensory trick. Work productivity results at baseline and final visit were compared in subjects who were toxin-naïve at baseline and received three onabotulinumtoxinA treatments. Results: Of 1,038 subjects, 42.8% were employed full- or part-time, 6.1% unemployed, 32.7% retired, and 11.8% disabled. Of those currently employed, cervical dystonia affected work status of 26.0%, caused 29.8% to miss work in the past month (mean, 5.1 ± 6.4 days), and 57.8% reported decreased productivity. Half of those unemployed were employed when symptoms began, and 38.5% attributed lost employment to cervical dystonia. Pain, increasing severity, and anterocollis/retrocollis had the largest effects on work status/productivity. Preliminary analyses showed that absenteeism and presenteeism were significantly decreased following onabotulinumtoxinA treatments in the subpopulation that was toxin-naïve at baseline. Conclusions: This analysis confirms the substantial negative impact of cervical dystonia on employment, with cervical dystonia-associated pain being a particularly important driver. OnabotulinumtoxinA treatment appears to improve work productivity.

Original languageEnglish (US)
Pages (from-to)130-138
Number of pages9
JournalMovement Disorders Clinical Practice
Volume3
Issue number2
DOIs
StatePublished - Mar 1 2016

Fingerprint

Torticollis
Registries
Efficiency
Pain
Absenteeism
Botulinum Toxins
Therapeutics
Observation
onabotulinumtoxinA

Keywords

  • Botulinum toxin
  • Cervical dystonia
  • Employment

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Impact of Cervical Dystonia on Work Productivity : An Analysis From a Patient Registry. / Molho, Eric S.; Stacy, Mark; Gillard, Patrick; Charles, David; Adler, Charles Howard; Jankovic, Joseph; Schwartz, Marc; Brin, Mitchell F.

In: Movement Disorders Clinical Practice, Vol. 3, No. 2, 01.03.2016, p. 130-138.

Research output: Contribution to journalArticle

Molho, ES, Stacy, M, Gillard, P, Charles, D, Adler, CH, Jankovic, J, Schwartz, M & Brin, MF 2016, 'Impact of Cervical Dystonia on Work Productivity: An Analysis From a Patient Registry', Movement Disorders Clinical Practice, vol. 3, no. 2, pp. 130-138. https://doi.org/10.1002/mdc3.12238
Molho, Eric S. ; Stacy, Mark ; Gillard, Patrick ; Charles, David ; Adler, Charles Howard ; Jankovic, Joseph ; Schwartz, Marc ; Brin, Mitchell F. / Impact of Cervical Dystonia on Work Productivity : An Analysis From a Patient Registry. In: Movement Disorders Clinical Practice. 2016 ; Vol. 3, No. 2. pp. 130-138.
@article{105b7c10aa004d22be94b30b2767c6ff,
title = "Impact of Cervical Dystonia on Work Productivity: An Analysis From a Patient Registry",
abstract = "Background: Cervical dystonia is thought to result in high disease burden, but limited information exists on its impact on employment and work productivity. We utilized data from the Cervical Dystonia Patient Registry for the Observation of OnabotulinumtoxinA Efficacy (ClinicalTrials.gov identifier: NCT00836017) to assess the impact of cervical dystonia on employment and work productivity and examine the effect of onabotulinumtoxinA treatments on work productivity. Methods: Subjects completed a questionnaire on employment status and work productivity at baseline and final visit. Baseline data were examined by severity of cervical dystonia, predominant subtype, presence of pain, prior exposure to botulinum toxin, and/or utility of a sensory trick. Work productivity results at baseline and final visit were compared in subjects who were toxin-na{\"i}ve at baseline and received three onabotulinumtoxinA treatments. Results: Of 1,038 subjects, 42.8{\%} were employed full- or part-time, 6.1{\%} unemployed, 32.7{\%} retired, and 11.8{\%} disabled. Of those currently employed, cervical dystonia affected work status of 26.0{\%}, caused 29.8{\%} to miss work in the past month (mean, 5.1 ± 6.4 days), and 57.8{\%} reported decreased productivity. Half of those unemployed were employed when symptoms began, and 38.5{\%} attributed lost employment to cervical dystonia. Pain, increasing severity, and anterocollis/retrocollis had the largest effects on work status/productivity. Preliminary analyses showed that absenteeism and presenteeism were significantly decreased following onabotulinumtoxinA treatments in the subpopulation that was toxin-na{\"i}ve at baseline. Conclusions: This analysis confirms the substantial negative impact of cervical dystonia on employment, with cervical dystonia-associated pain being a particularly important driver. OnabotulinumtoxinA treatment appears to improve work productivity.",
keywords = "Botulinum toxin, Cervical dystonia, Employment",
author = "Molho, {Eric S.} and Mark Stacy and Patrick Gillard and David Charles and Adler, {Charles Howard} and Joseph Jankovic and Marc Schwartz and Brin, {Mitchell F.}",
year = "2016",
month = "3",
day = "1",
doi = "10.1002/mdc3.12238",
language = "English (US)",
volume = "3",
pages = "130--138",
journal = "Movement Disorders Clinical Practice",
issn = "2330-1619",
publisher = "John Wiley and Sons Ltd",
number = "2",

}

TY - JOUR

T1 - Impact of Cervical Dystonia on Work Productivity

T2 - An Analysis From a Patient Registry

AU - Molho, Eric S.

AU - Stacy, Mark

AU - Gillard, Patrick

AU - Charles, David

AU - Adler, Charles Howard

AU - Jankovic, Joseph

AU - Schwartz, Marc

AU - Brin, Mitchell F.

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Background: Cervical dystonia is thought to result in high disease burden, but limited information exists on its impact on employment and work productivity. We utilized data from the Cervical Dystonia Patient Registry for the Observation of OnabotulinumtoxinA Efficacy (ClinicalTrials.gov identifier: NCT00836017) to assess the impact of cervical dystonia on employment and work productivity and examine the effect of onabotulinumtoxinA treatments on work productivity. Methods: Subjects completed a questionnaire on employment status and work productivity at baseline and final visit. Baseline data were examined by severity of cervical dystonia, predominant subtype, presence of pain, prior exposure to botulinum toxin, and/or utility of a sensory trick. Work productivity results at baseline and final visit were compared in subjects who were toxin-naïve at baseline and received three onabotulinumtoxinA treatments. Results: Of 1,038 subjects, 42.8% were employed full- or part-time, 6.1% unemployed, 32.7% retired, and 11.8% disabled. Of those currently employed, cervical dystonia affected work status of 26.0%, caused 29.8% to miss work in the past month (mean, 5.1 ± 6.4 days), and 57.8% reported decreased productivity. Half of those unemployed were employed when symptoms began, and 38.5% attributed lost employment to cervical dystonia. Pain, increasing severity, and anterocollis/retrocollis had the largest effects on work status/productivity. Preliminary analyses showed that absenteeism and presenteeism were significantly decreased following onabotulinumtoxinA treatments in the subpopulation that was toxin-naïve at baseline. Conclusions: This analysis confirms the substantial negative impact of cervical dystonia on employment, with cervical dystonia-associated pain being a particularly important driver. OnabotulinumtoxinA treatment appears to improve work productivity.

AB - Background: Cervical dystonia is thought to result in high disease burden, but limited information exists on its impact on employment and work productivity. We utilized data from the Cervical Dystonia Patient Registry for the Observation of OnabotulinumtoxinA Efficacy (ClinicalTrials.gov identifier: NCT00836017) to assess the impact of cervical dystonia on employment and work productivity and examine the effect of onabotulinumtoxinA treatments on work productivity. Methods: Subjects completed a questionnaire on employment status and work productivity at baseline and final visit. Baseline data were examined by severity of cervical dystonia, predominant subtype, presence of pain, prior exposure to botulinum toxin, and/or utility of a sensory trick. Work productivity results at baseline and final visit were compared in subjects who were toxin-naïve at baseline and received three onabotulinumtoxinA treatments. Results: Of 1,038 subjects, 42.8% were employed full- or part-time, 6.1% unemployed, 32.7% retired, and 11.8% disabled. Of those currently employed, cervical dystonia affected work status of 26.0%, caused 29.8% to miss work in the past month (mean, 5.1 ± 6.4 days), and 57.8% reported decreased productivity. Half of those unemployed were employed when symptoms began, and 38.5% attributed lost employment to cervical dystonia. Pain, increasing severity, and anterocollis/retrocollis had the largest effects on work status/productivity. Preliminary analyses showed that absenteeism and presenteeism were significantly decreased following onabotulinumtoxinA treatments in the subpopulation that was toxin-naïve at baseline. Conclusions: This analysis confirms the substantial negative impact of cervical dystonia on employment, with cervical dystonia-associated pain being a particularly important driver. OnabotulinumtoxinA treatment appears to improve work productivity.

KW - Botulinum toxin

KW - Cervical dystonia

KW - Employment

UR - http://www.scopus.com/inward/record.url?scp=85028080840&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85028080840&partnerID=8YFLogxK

U2 - 10.1002/mdc3.12238

DO - 10.1002/mdc3.12238

M3 - Article

AN - SCOPUS:85028080840

VL - 3

SP - 130

EP - 138

JO - Movement Disorders Clinical Practice

JF - Movement Disorders Clinical Practice

SN - 2330-1619

IS - 2

ER -