Impact of bipolar disorder on a U.S. community sample

Joseph R. Calabrese, Robert M.A. Hirschfeld, Michael Reed, Marilyn A. Davies, Mark A. Frye, Paul E. Keck, Lydia Lewis, Susan L. McElroy, James P. McNulty, Karen D. Wagner

Research output: Contribution to journalArticle

252 Scopus citations

Abstract

Background: Bipolar disorder is a chronic psychiatric illness characterized by depression and at least 1 manic or hypomanic episode during the lifetime of the illness. Bipolar symptoms have been associated with significant functional impairment. We conducted a study to determine the psychosocial impact of bipolar disorder in a U.S. community sample. Method: 3059 subjects were selected from a large epidemiologic study of bipolar prevalence that used the Mood Disorder Questionnaire (MDQ) to screen for bipolar I and II disorder. Subjects were surveyed from April 24, 2001, to August 6, 2001, using the Sheehan Disability Scale and the Social Adjustment Scale-Self Report. Comorbid disease data were also collected. Results: Of the 3059 subjects surveyed, 2450 (80%) returned completed surveys: 1167 (48%) subjects screened positive for bipolar disorder based on MDQ scores; 1283 (52%) screened negative. MDQ-positive subjects reported significantly (p < .0001) more difficulties with workrelated performance, social/leisure activities, and social/family interactions compared with MDQ-negative subjects. Younger subjects, aged 18 to 34 years, reported significantly (p = .003) more symptom days than did older MDQ-positive subjects. MDQ-positive women reported more disruption in social and family life, while MDQ-positive men reported being jailed, arrested, and convicted for crimes. Anxiety (30% vs. 6%), panic attacks (18% vs. 4%), migraine (24% vs. 11%), asthma (17% vs. 10%), and allergies (42% vs. 29%) were significantly (p < .05) more common in MDQ-positive versus MDQ-negative subjects. Conclusion: Bipolar disorder, as identified in a community sample using the Mood Disorder Questionnaire, was significantly associated with negative impact on the performance of workrelated, leisure, and interpersonal activities.

Original languageEnglish (US)
Pages (from-to)425-432
Number of pages8
JournalJournal of Clinical Psychiatry
Volume64
Issue number4
DOIs
StatePublished - Apr 1 2003

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    Calabrese, J. R., Hirschfeld, R. M. A., Reed, M., Davies, M. A., Frye, M. A., Keck, P. E., Lewis, L., McElroy, S. L., McNulty, J. P., & Wagner, K. D. (2003). Impact of bipolar disorder on a U.S. community sample. Journal of Clinical Psychiatry, 64(4), 425-432. https://doi.org/10.4088/JCP.v64n0412