Impact of Benzodiazepine Use on Length of Stay and 30-Day ED Visits among Hospitalized Hematopoietic Stem Cell Transplant Recipients

Shehzad K Niazi, Madiha Iqbal, Aaron Spaulding, Chanel Wood, Rami Manochakian, Aneel Paulus, Sikander Ailawadhi, Emily Brennan, Mohamed A. Kharfan Dabaja, Taimur Sher

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives This study assesses the impact of benzodiazepine (BNZ) use on length of stay (LOS) and 30-day emergency department (ED) visits after hematopoietic stem cell transplant (HSCT). Methods Adult patients (18 years and older) who underwent an allogeneic or an autologous HSCT from 2015 to 2018 at the study site were included. Five multivariable models were used for both allogeneic and autologous HSCT: BNZ-naïve status, diazepam equivalent daily dosage (DEDD; 0 vs any), DEDD (excluding 0), ED visits, and LOS. Results BNZ-naïve autologous HSCT recipients were less likely to use any BNZs in the hospital (odds ratio [OR] 0.07, P < 0.001). If prescribed BNZs, then they used a lesser amount (incidence rate ratio 0.39, P < 0.001). BNZ-naïve autologous HSCT recipients were less likely to experience a 30-day ED visit (OR 0.17, P = 0.009). BNZ-naïve allogeneic HSCT recipients were also less likely to use any BNZ than previous users (OR 0.11, P = 0.014). Patient characteristics influenced BNZ naïvety, DEDD usage, LOS for autologous patients, and BNZ naïvety and DEDD for allogeneic patients. Conclusions BNZ use resulted in increased 30-day ED visits after autologous HSCT. BNZ-naïve recipients were less likely to use BNZs during hospital stays; if they required BNZs, then it was in lower dosages.

Original languageEnglish (US)
Pages (from-to)936-943
Number of pages8
JournalSouthern medical journal
Volume115
Issue number12
DOIs
StatePublished - Dec 1 2022

Keywords

  • benzodiazepines
  • emergency department visit
  • hematopoietic stem cell transplant
  • length of stay

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint

Dive into the research topics of 'Impact of Benzodiazepine Use on Length of Stay and 30-Day ED Visits among Hospitalized Hematopoietic Stem Cell Transplant Recipients'. Together they form a unique fingerprint.

Cite this