Impact of angiotensin-converting enzyme inhibitors and statins on survival in idiopathic pulmonary fibrosis

Hassan F. Nadrous, Jay H. Ryu, William W. Douglas, Paul A. Decker, Eric J. Olson

Research output: Contribution to journalReview articlepeer-review

68 Scopus citations

Abstract

Study objectives: To assess the clinical relevance of angiotensin- converting enzyme inhibitors (ACEI) and 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitors (statins) in the context of idiopathic pulmonary fibrosis (IPF). Background: IPF is a progressive interstitial lung disease for which there is no effective treatment. ACEI and statins have been shown to possess antifibrotic properties in experimental models in vitro and in vivo. Design, setting, and patients: Retrospective review of the effects of ACEI and statins on survival of 478 patients with IPF seen at Mayo Clinic Rochester from 1994 through 1996. Fifty-two patients (11%) were receiving ACEI, 35 patients (7%) were receiving statins, and 5 patients (1%) patients were receiving both at their initial visit. Results: For subjects receiving ACEI, the median survival from the index visit was 2.2 years, compared to 2.9 years for subjects not receiving ACEI (p = 0.088). The median survival was 2.9 years if patients were receiving statins or not (p = 0.573). There was also no significant difference in survival between patients with IPF receiving either ACEI or statins vs those receiving neither at the index visit (2.5 years vs 3 years, respectively; p = 0.066). After adjusting for age, gender, recommended IPF treatment, smoking status, prior oxygen use, FVC, diffusion capacity for carbon monoxide, coronary artery disease, congestive heart failure, diabetes mellitus, and hypertension, there were no differences in survival between those subjects receiving either ACEI, statins, or both vs neither. Conclusions: These data do not suggest a beneficial effect of ACEI and/or statins on survival in patients with IPF.

Original languageEnglish (US)
Pages (from-to)438-446
Number of pages9
JournalChest
Volume126
Issue number2
DOIs
StatePublished - Aug 2004

Keywords

  • Angiotensin-converting enzyme inhibitors
  • Idiopathic pulmonary fibrosis
  • Statins
  • Treatment

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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