Impact of alemtuzumab therapy and route of administration in T-prolymphocytic leukemia: A single-center experience

Moussab Damlaj, Nanna H. Sulai, Jennifer Oliveira, Rhett P. Ketterling, Shahrukh Hashmi, Thomas Elmer Witzig, Grzegorz S Nowakowski, Timothy G. Call, Tait D. Shanafelt, Wei D Ding, William Hogan, Mark R Litzow, Mrinal M Patnaik

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Objective We conducted a single-center retrospective analysis to determine the impact of the anti-CD52 monoclonal antibody alemtuzumab including route of administration compared to non-alemtuzumab-containing regimens in T-prolymphocytic leukemia (T-PLL). Patients and Methods The study was a retrospective analysis of a consecutive cohort of adult patients diagnosed with T-PLL at Mayo Clinic Rochester from January 1, 1997, through September 30, 2014. Results A total of 41 patients were diagnosed with T-PLL per the World Health Organization 2008 classification. The median age was 66 years, and 23 (56%) were male. After a median follow-up of 18 months (range, 0.4-66.1 months), 32 patients (78%) had died, with a median overall survival of 16.9 months. Approximately half the cohort was treated with alemtuzumab, almost exclusively after 2004. Median survival for patients receiving intravenous alemtuzumab-based therapy was 40.5 versus 10.3 months for all other therapies (P =.0004). A significant survival difference between intravenous versus subcutaneous alemtuzumab administration of 40.5 versus 13.7 months was noted (P =.0014). Only 4 (14%) of 28 patients aged <70 years underwent hematopoietic stem cell transplantation, with a median survival after transplantation of 4 months. Conclusion In this large series of T-PLL patients treated at a single tertiary-care center, we confirmed the prior observation of the superiority of intravenous alemtuzumab over other therapies. Hematopoietic stem cell transplantation was feasible in a minority of potentially eligible patients. Early transplant referral should be considered for all eligible patients.

Original languageEnglish (US)
Pages (from-to)699-704
Number of pages6
JournalClinical Lymphoma, Myeloma and Leukemia
Issue number11
StatePublished - Nov 1 2015


  • Alemtuzumab
  • GVHD
  • HSCT
  • T-PLL

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Fingerprint Dive into the research topics of 'Impact of alemtuzumab therapy and route of administration in T-prolymphocytic leukemia: A single-center experience'. Together they form a unique fingerprint.

Cite this