Impact of age, sex and body mass index on cortisol secretion in 143 healthy adults

Ferdinand Roelfsema, Diana Van Heemst, Ali Iranmanesh, Paul Y Takahashi, Rebecca Yang, Johannes D Veldhuis

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Context: Studies on 24-h cortisol secretion are rare. The impact of sex, age and adiposity on cortisol levels, often restricted to one or a few samples, are well recognized, but conflicting. Objective: To investigate cortisol dynamics in 143 healthy men and women, spanning 7 decades and with a 2-fold body mass index (BMI) range with different analytic tools. Setting: Clinical Research Unit. Design: Cortisol concentrations in 10-min samples collected for 24 h. Outcomes were mean levels, deconvolution parameters, approximate entropy (ApEn, regularity statistic) and 24-h rhythms. Results: Total 24-h cortisol secretion rates estimated by deconvolution analysis were sex, age and BMI independent. Mean 24-h cortisol concentrations were lower in premenopausal women than those in men of comparable age (176 ± 8.2 vs 217 ± 9.4 nmol/L, P = 0.02), but not in subjects older than 50 years. This was due to lower daytime levels in women, albeit similar in the quiescent overnight period. Aging increased mean cortisol by 10 nmol/L per decade during the quiescent secretory phase and advanced the acrophase of the diurnal rhythm by 24 min/decade. However, total 24-h cortisol secretion rates estimated by deconvolution analysis were sex, age and BMI independent. ApEn of 24-h profiles was higher (more random) in premenopausal women than those in men (1.048 ± 0.025 vs 0.933 ± 0.023, P = 0.001), but not in subjects older than 50 years. ApEn peaked during the daytime. Conclusion: Sex and age jointly determine the 24-h cortisol secretory profile. Sex effects are largely restricted to age <50 years, whereas age effects elevate concentrations in the late evening and early night and advance the timing of the peak diurnal rhythm.

Original languageEnglish (US)
Pages (from-to)500-509
Number of pages10
JournalEndocrine Connections
Volume6
Issue number7
DOIs
StatePublished - Oct 1 2017

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Hydrocortisone
Body Mass Index
Circadian Rhythm
Adiposity
Entropy
Research

Keywords

  • Approximate entropy
  • Circadian rhythms
  • Cortisol
  • Deconvolution
  • Human

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Impact of age, sex and body mass index on cortisol secretion in 143 healthy adults. / Roelfsema, Ferdinand; Van Heemst, Diana; Iranmanesh, Ali; Takahashi, Paul Y; Yang, Rebecca; Veldhuis, Johannes D.

In: Endocrine Connections, Vol. 6, No. 7, 01.10.2017, p. 500-509.

Research output: Contribution to journalArticle

Roelfsema, F, Van Heemst, D, Iranmanesh, A, Takahashi, PY, Yang, R & Veldhuis, JD 2017, 'Impact of age, sex and body mass index on cortisol secretion in 143 healthy adults', Endocrine Connections, vol. 6, no. 7, pp. 500-509. https://doi.org/10.1530/EC-17-0160
Roelfsema, Ferdinand ; Van Heemst, Diana ; Iranmanesh, Ali ; Takahashi, Paul Y ; Yang, Rebecca ; Veldhuis, Johannes D. / Impact of age, sex and body mass index on cortisol secretion in 143 healthy adults. In: Endocrine Connections. 2017 ; Vol. 6, No. 7. pp. 500-509.
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