Impact of acute rejection and early allograft function on renal allograft survival

Fernando G Cosio, Ronald P. Pelletier, Michael E. Falkenhain, Mitchell L. Henry, Elmahdi A. Elkhammas, Elizabeth A. Davies, Ginny L. Bumgardner, Ronald M. Ferguson

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Both acute rejection and the function of a renal allograft early after transplantation correlate with longterm graft survival. In this study we assessed the relationship between these two factors in 843 adult recipients of first cadaveric renal grafts, transplanted at a single institution and followed for a minimum of 3.5 years. Patients were divided into four groups according to (1) history of acute rejection (AR) during the first 6 months after transplantation, and (2) concentration of serum creatinine at 6 months after transplantation (SCr(6mo) < or ≤2 mg/dl). Death censored allograft survival was not significantly different among patients without AR and with low SCr(6mo) (group 1, n=876), patients without AR but with an elevated SCr(6mo) (group 2, n=117), and patients with AR but low SCr(6mo) (group 3, n=185). In contrast, graft survival was significantly worse in patients with AIR and an elevated SCr(6mo) (group 4, n=165) compared with patients in the other three groups (Cox, P<0.0001). The elevated SCr(6mo) in group 4 patients was not necessarily the consequence of AR, as 32% of patients in group 4 had a SCr at 10 days after transplantation (SCr(10d)), before they had AR, that was equal to or higher than the SCr(6mo). Based on this observation we investigated the implications of the SCr(10d) concentration for graft prognosis. The SCr(10d) correlated weakly with graft survival (Cox, P=0.05). However, an elevated SCr(10d) correlated with other potential risk factors for graft survival including: Older donors (P<0.0001), male recipients (P<0.0001), and heavier recipients (P<0.0001, all by multivariate regression); and posttransplant factors such as, increasing numbers of AR (P<0.0001), higher posttransplant blood pressure (P<0.0001), and lower doses of cyclosporine (P<0.0001, all by multivariate regression). In conclusion, graft dysfunction predicts poor graft survival only when associated with AR. Similarly, AR predicts a poor renal allograft survival only when associated with graft dysfunction. The SCr(10d) is an indicator of risk factors from both the donor and recipient, and an elevated SCr(10d) predicts a higher risk of acquiring additional risk factors early after transplantation.

Original languageEnglish (US)
Pages (from-to)1611-1615
Number of pages5
JournalTransplantation
Volume63
Issue number11
DOIs
StatePublished - Jun 15 1997
Externally publishedYes

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Allografts
Graft Survival
Kidney
Transplantation
Transplants
Tissue Donors
Cyclosporine
Creatinine
Hypertension
Serum

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Cosio, F. G., Pelletier, R. P., Falkenhain, M. E., Henry, M. L., Elkhammas, E. A., Davies, E. A., ... Ferguson, R. M. (1997). Impact of acute rejection and early allograft function on renal allograft survival. Transplantation, 63(11), 1611-1615. https://doi.org/10.1097/00007890-199706150-00013

Impact of acute rejection and early allograft function on renal allograft survival. / Cosio, Fernando G; Pelletier, Ronald P.; Falkenhain, Michael E.; Henry, Mitchell L.; Elkhammas, Elmahdi A.; Davies, Elizabeth A.; Bumgardner, Ginny L.; Ferguson, Ronald M.

In: Transplantation, Vol. 63, No. 11, 15.06.1997, p. 1611-1615.

Research output: Contribution to journalArticle

Cosio, FG, Pelletier, RP, Falkenhain, ME, Henry, ML, Elkhammas, EA, Davies, EA, Bumgardner, GL & Ferguson, RM 1997, 'Impact of acute rejection and early allograft function on renal allograft survival', Transplantation, vol. 63, no. 11, pp. 1611-1615. https://doi.org/10.1097/00007890-199706150-00013
Cosio FG, Pelletier RP, Falkenhain ME, Henry ML, Elkhammas EA, Davies EA et al. Impact of acute rejection and early allograft function on renal allograft survival. Transplantation. 1997 Jun 15;63(11):1611-1615. https://doi.org/10.1097/00007890-199706150-00013
Cosio, Fernando G ; Pelletier, Ronald P. ; Falkenhain, Michael E. ; Henry, Mitchell L. ; Elkhammas, Elmahdi A. ; Davies, Elizabeth A. ; Bumgardner, Ginny L. ; Ferguson, Ronald M. / Impact of acute rejection and early allograft function on renal allograft survival. In: Transplantation. 1997 ; Vol. 63, No. 11. pp. 1611-1615.
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AU - Elkhammas, Elmahdi A.

AU - Davies, Elizabeth A.

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AU - Ferguson, Ronald M.

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N2 - Both acute rejection and the function of a renal allograft early after transplantation correlate with longterm graft survival. In this study we assessed the relationship between these two factors in 843 adult recipients of first cadaveric renal grafts, transplanted at a single institution and followed for a minimum of 3.5 years. Patients were divided into four groups according to (1) history of acute rejection (AR) during the first 6 months after transplantation, and (2) concentration of serum creatinine at 6 months after transplantation (SCr(6mo) < or ≤2 mg/dl). Death censored allograft survival was not significantly different among patients without AR and with low SCr(6mo) (group 1, n=876), patients without AR but with an elevated SCr(6mo) (group 2, n=117), and patients with AR but low SCr(6mo) (group 3, n=185). In contrast, graft survival was significantly worse in patients with AIR and an elevated SCr(6mo) (group 4, n=165) compared with patients in the other three groups (Cox, P<0.0001). The elevated SCr(6mo) in group 4 patients was not necessarily the consequence of AR, as 32% of patients in group 4 had a SCr at 10 days after transplantation (SCr(10d)), before they had AR, that was equal to or higher than the SCr(6mo). Based on this observation we investigated the implications of the SCr(10d) concentration for graft prognosis. The SCr(10d) correlated weakly with graft survival (Cox, P=0.05). However, an elevated SCr(10d) correlated with other potential risk factors for graft survival including: Older donors (P<0.0001), male recipients (P<0.0001), and heavier recipients (P<0.0001, all by multivariate regression); and posttransplant factors such as, increasing numbers of AR (P<0.0001), higher posttransplant blood pressure (P<0.0001), and lower doses of cyclosporine (P<0.0001, all by multivariate regression). In conclusion, graft dysfunction predicts poor graft survival only when associated with AR. Similarly, AR predicts a poor renal allograft survival only when associated with graft dysfunction. The SCr(10d) is an indicator of risk factors from both the donor and recipient, and an elevated SCr(10d) predicts a higher risk of acquiring additional risk factors early after transplantation.

AB - Both acute rejection and the function of a renal allograft early after transplantation correlate with longterm graft survival. In this study we assessed the relationship between these two factors in 843 adult recipients of first cadaveric renal grafts, transplanted at a single institution and followed for a minimum of 3.5 years. Patients were divided into four groups according to (1) history of acute rejection (AR) during the first 6 months after transplantation, and (2) concentration of serum creatinine at 6 months after transplantation (SCr(6mo) < or ≤2 mg/dl). Death censored allograft survival was not significantly different among patients without AR and with low SCr(6mo) (group 1, n=876), patients without AR but with an elevated SCr(6mo) (group 2, n=117), and patients with AR but low SCr(6mo) (group 3, n=185). In contrast, graft survival was significantly worse in patients with AIR and an elevated SCr(6mo) (group 4, n=165) compared with patients in the other three groups (Cox, P<0.0001). The elevated SCr(6mo) in group 4 patients was not necessarily the consequence of AR, as 32% of patients in group 4 had a SCr at 10 days after transplantation (SCr(10d)), before they had AR, that was equal to or higher than the SCr(6mo). Based on this observation we investigated the implications of the SCr(10d) concentration for graft prognosis. The SCr(10d) correlated weakly with graft survival (Cox, P=0.05). However, an elevated SCr(10d) correlated with other potential risk factors for graft survival including: Older donors (P<0.0001), male recipients (P<0.0001), and heavier recipients (P<0.0001, all by multivariate regression); and posttransplant factors such as, increasing numbers of AR (P<0.0001), higher posttransplant blood pressure (P<0.0001), and lower doses of cyclosporine (P<0.0001, all by multivariate regression). In conclusion, graft dysfunction predicts poor graft survival only when associated with AR. Similarly, AR predicts a poor renal allograft survival only when associated with graft dysfunction. The SCr(10d) is an indicator of risk factors from both the donor and recipient, and an elevated SCr(10d) predicts a higher risk of acquiring additional risk factors early after transplantation.

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