Impact of Acute Moderate Elevation in Left Ventricular Afterload on Diastolic Transmitral Flow Efficiency: Analysis by Vortex Formation Time

Panupong Jiamsripong, Anna M. Calleja, Mohsen S. Alharthi, Mate Dzsinich, Eileen M. McMahon, Jeffrey J. Heys, Michele Milano, Partho P. Sengupta, Bijoy K. Khandheria, Marek Belohlavek

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Background: The formation of a vortex alongside a diastolic jet signifies an efficient blood transport mechanism. Vortex formation time (VFT) is an index of the optimal conditions for vortex formation. It was hypothesized that left ventricular (LV) afterload impairs diastolic transmitral flow efficiency and therefore shifts the VFT out of its optimal range. Methods: In 9 open-chest pigs, LV afterload was elevated by externally constricting the ascending aorta and increasing systolic blood pressure to 130% of baseline value for 3 minutes. Results: Systolic LV function decreased, diastolic filling velocity increased only during the late (atrial) phase from 0.46 ± 0.06 to 0.63 ± 0.19 m/s (P = .0231), and end-diastolic LV volume and heart rate remained unchanged. VFT decreased from 4.09 ± 0.27 to 2.78 ± 1.03 (P = .0046). Conclusion: An acute, moderate elevation in LV afterload worsens conditions for diastolic vortex formation, suggesting impaired blood transport efficiency.

Original languageEnglish (US)
Pages (from-to)427-431
Number of pages5
JournalJournal of the American Society of Echocardiography
Volume22
Issue number4
DOIs
StatePublished - Apr 2009

Keywords

  • Blood flow velocity
  • Diastolic filling
  • Vortex formation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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    Jiamsripong, P., Calleja, A. M., Alharthi, M. S., Dzsinich, M., McMahon, E. M., Heys, J. J., Milano, M., Sengupta, P. P., Khandheria, B. K., & Belohlavek, M. (2009). Impact of Acute Moderate Elevation in Left Ventricular Afterload on Diastolic Transmitral Flow Efficiency: Analysis by Vortex Formation Time. Journal of the American Society of Echocardiography, 22(4), 427-431. https://doi.org/10.1016/j.echo.2008.12.006