Immunotransplant: Preventing unintended consequences

Research output: Contribution to journalArticle

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Abstract

T-cell transfer into lymphodepleted recipients results not only in homeostatic activation of the infused cells but also in T-cell inhibition due to upregulation of immune checkpoint receptors including PD-1 and CTLA4, thereby mitigating T-cell efficacy. Dual checkpoint blockade of PD-1 and CTLA4 in conjunction with lymphodepletion—an “immunotransplant”—uncouples the T-cell inhibition from activation and amplifies the T-cell antitumor immune response.

Original languageEnglish (US)
Pages (from-to)1487-1489
Number of pages3
JournalCancer discovery
Volume9
Issue number11
DOIs
StatePublished - Nov 2019

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ASJC Scopus subject areas

  • Oncology

Cite this

Immunotransplant : Preventing unintended consequences. / Ansell, Stephen M.

In: Cancer discovery, Vol. 9, No. 11, 11.2019, p. 1487-1489.

Research output: Contribution to journalArticle