Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine

Yu Quan Wei; Qing Ru Wang; Xia Zhao; Li Yang; Ling Tian; You Lu; Bin Kang; Chong Jiu Lu; Mei Juan Huang; Yan Yan Lou; Fei Xiao; Qiu Ming He; Jing Mei Shu; Xing Jiang Xie; Yun Qiu Mao; Shong Lei; Feng Luo; Li Qun Zhou; Chong En Liu; Hao Zhou; Yu Jiang; Feng Peng; Liang Ping Yuan; Qiu Li; Yang Wu; Ji Yan Liu

doi:10.1038/80506

Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine

Yu Quan Wei, Qing Ru Wang, Xia Zhao, Li Yang, Ling Tian, You Lu, Bin Kang, Chong Jiu Lu, Mei Juan Huang, Yan Yan Lou, Fei Xiao, Qiu Ming He, Jing Mei Shu, Xing Jiang Xie, Yun Qiu Mao, Shong Lei, Feng Luo, Li Qun Zhou, Chong En Liu, Hao ZhouYu Jiang, Feng Peng, Liang Ping Yuan, Qiu Li, Yang Wu, Ji Yan Liu

Hematology / Oncology / Cancer Center / Breast Clinic

Research output: Contribution to journal › Article › peer-review

236 Scopus citations

Abstract

The breaking of immune tolerance against autologous angiogenic endothelial cells should be a useful approach for cancer theraphy. Here we show that immunotherapy of tumors using fixed xenogeneic whole endothelial cells as a vaccine was effective in affording protection from tumor growth, inducing regression of established tumors and prolonging survival of tumor-bearing mice. Furthermore, autoreactive immunity targeting to microvessels in solid tumors was induced and was probably responsible for the anti-tumor activity. These observations may provide a new vaccine strategy for cancer therapy through the induction of an autoimmune response against the tumor endothelium in a cross-reaction.

Original language	English (US)
Pages (from-to)	1160-1166
Number of pages	7
Journal	Nature Medicine
Volume	6
Issue number	10
DOIs	https://doi.org/10.1038/80506
State	Published - 2000

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine. / Wei, Yu Quan; Wang, Qing Ru; Zhao, Xia; Yang, Li; Tian, Ling; Lu, You; Kang, Bin; Lu, Chong Jiu; Huang, Mei Juan; Lou, Yan Yan; Xiao, Fei; He, Qiu Ming; Shu, Jing Mei; Xie, Xing Jiang; Mao, Yun Qiu; Lei, Shong; Luo, Feng; Zhou, Li Qun; Liu, Chong En; Zhou, Hao; Jiang, Yu; Peng, Feng; Yuan, Liang Ping; Li, Qiu; Wu, Yang; Liu, Ji Yan.

In: Nature Medicine, Vol. 6, No. 10, 2000, p. 1160-1166.

Research output: Contribution to journal › Article › peer-review

Wei, YQ, Wang, QR, Zhao, X, Yang, L, Tian, L, Lu, Y, Kang, B, Lu, CJ, Huang, MJ, Lou, YY, Xiao, F, He, QM, Shu, JM, Xie, XJ, Mao, YQ, Lei, S, Luo, F, Zhou, LQ, Liu, CE, Zhou, H, Jiang, Y, Peng, F, Yuan, LP, Li, Q, Wu, Y & Liu, JY 2000, 'Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine', Nature Medicine, vol. 6, no. 10, pp. 1160-1166. https://doi.org/10.1038/80506

Wei, Yu Quan ; Wang, Qing Ru ; Zhao, Xia ; Yang, Li ; Tian, Ling ; Lu, You ; Kang, Bin ; Lu, Chong Jiu ; Huang, Mei Juan ; Lou, Yan Yan ; Xiao, Fei ; He, Qiu Ming ; Shu, Jing Mei ; Xie, Xing Jiang ; Mao, Yun Qiu ; Lei, Shong ; Luo, Feng ; Zhou, Li Qun ; Liu, Chong En ; Zhou, Hao ; Jiang, Yu ; Peng, Feng ; Yuan, Liang Ping ; Li, Qiu ; Wu, Yang ; Liu, Ji Yan. / Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine. In: Nature Medicine. 2000 ; Vol. 6, No. 10. pp. 1160-1166.

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title = "Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine",

abstract = "The breaking of immune tolerance against autologous angiogenic endothelial cells should be a useful approach for cancer theraphy. Here we show that immunotherapy of tumors using fixed xenogeneic whole endothelial cells as a vaccine was effective in affording protection from tumor growth, inducing regression of established tumors and prolonging survival of tumor-bearing mice. Furthermore, autoreactive immunity targeting to microvessels in solid tumors was induced and was probably responsible for the anti-tumor activity. These observations may provide a new vaccine strategy for cancer therapy through the induction of an autoimmune response against the tumor endothelium in a cross-reaction.",

author = "Wei, {Yu Quan} and Wang, {Qing Ru} and Xia Zhao and Li Yang and Ling Tian and You Lu and Bin Kang and Lu, {Chong Jiu} and Huang, {Mei Juan} and Lou, {Yan Yan} and Fei Xiao and He, {Qiu Ming} and Shu, {Jing Mei} and Xie, {Xing Jiang} and Mao, {Yun Qiu} and Shong Lei and Feng Luo and Zhou, {Li Qun} and Liu, {Chong En} and Hao Zhou and Yu Jiang and Feng Peng and Yuan, {Liang Ping} and Qiu Li and Yang Wu and Liu, {Ji Yan}",

note = "Funding Information: Acknowledgments This work was supported by the National Outstanding Young Scientist Foundation of China, the National Natural Sciences Foundation of China, the National 973 Project and the Foundation for University Key Teacher.",

year = "2000",

doi = "10.1038/80506",

language = "English (US)",

volume = "6",

pages = "1160--1166",

journal = "Nature Medicine",

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AU - Wei, Yu Quan

AU - Wang, Qing Ru

AU - Zhao, Xia

AU - Yang, Li

AU - Tian, Ling

AU - Lu, You

AU - Kang, Bin

AU - Lu, Chong Jiu

AU - Huang, Mei Juan

AU - Lou, Yan Yan

AU - Xiao, Fei

AU - He, Qiu Ming

AU - Shu, Jing Mei

AU - Xie, Xing Jiang

AU - Mao, Yun Qiu

AU - Lei, Shong

AU - Luo, Feng

AU - Zhou, Li Qun

AU - Liu, Chong En

AU - Zhou, Hao

AU - Jiang, Yu

AU - Peng, Feng

AU - Yuan, Liang Ping

AU - Li, Qiu

AU - Wu, Yang

AU - Liu, Ji Yan

N1 - Funding Information: Acknowledgments This work was supported by the National Outstanding Young Scientist Foundation of China, the National Natural Sciences Foundation of China, the National 973 Project and the Foundation for University Key Teacher.

PY - 2000

Y1 - 2000

N2 - The breaking of immune tolerance against autologous angiogenic endothelial cells should be a useful approach for cancer theraphy. Here we show that immunotherapy of tumors using fixed xenogeneic whole endothelial cells as a vaccine was effective in affording protection from tumor growth, inducing regression of established tumors and prolonging survival of tumor-bearing mice. Furthermore, autoreactive immunity targeting to microvessels in solid tumors was induced and was probably responsible for the anti-tumor activity. These observations may provide a new vaccine strategy for cancer therapy through the induction of an autoimmune response against the tumor endothelium in a cross-reaction.

AB - The breaking of immune tolerance against autologous angiogenic endothelial cells should be a useful approach for cancer theraphy. Here we show that immunotherapy of tumors using fixed xenogeneic whole endothelial cells as a vaccine was effective in affording protection from tumor growth, inducing regression of established tumors and prolonging survival of tumor-bearing mice. Furthermore, autoreactive immunity targeting to microvessels in solid tumors was induced and was probably responsible for the anti-tumor activity. These observations may provide a new vaccine strategy for cancer therapy through the induction of an autoimmune response against the tumor endothelium in a cross-reaction.

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Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine

Abstract

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