Abstract
The breaking of immune tolerance against autologous angiogenic endothelial cells should be a useful approach for cancer theraphy. Here we show that immunotherapy of tumors using fixed xenogeneic whole endothelial cells as a vaccine was effective in affording protection from tumor growth, inducing regression of established tumors and prolonging survival of tumor-bearing mice. Furthermore, autoreactive immunity targeting to microvessels in solid tumors was induced and was probably responsible for the anti-tumor activity. These observations may provide a new vaccine strategy for cancer therapy through the induction of an autoimmune response against the tumor endothelium in a cross-reaction.
Original language | English (US) |
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Pages (from-to) | 1160-1166 |
Number of pages | 7 |
Journal | Nature Medicine |
Volume | 6 |
Issue number | 10 |
DOIs | |
State | Published - 2000 |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)