Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine

Yu Quan Wei, Qing Ru Wang, Xia Zhao, Li Yang, Ling Tian, You Lu, Bin Kang, Chong Jiu Lu, Mei Juan Huang, Yan Yan Lou, Fei Xiao, Qiu Ming He, Jing Mei Shu, Xing Jiang Xie, Yun Qiu Mao, Shong Lei, Feng Luo, Li Qun Zhou, Chong En Liu, Hao ZhouYu Jiang, Feng Peng, Liang Ping Yuan, Qiu Li, Yang Wu, Ji Yan Liu

Research output: Contribution to journalArticle

231 Scopus citations

Abstract

The breaking of immune tolerance against autologous angiogenic endothelial cells should be a useful approach for cancer theraphy. Here we show that immunotherapy of tumors using fixed xenogeneic whole endothelial cells as a vaccine was effective in affording protection from tumor growth, inducing regression of established tumors and prolonging survival of tumor-bearing mice. Furthermore, autoreactive immunity targeting to microvessels in solid tumors was induced and was probably responsible for the anti-tumor activity. These observations may provide a new vaccine strategy for cancer therapy through the induction of an autoimmune response against the tumor endothelium in a cross-reaction.

Original languageEnglish (US)
Pages (from-to)1160-1166
Number of pages7
JournalNature Medicine
Volume6
Issue number10
DOIs
StatePublished - Nov 2 2000

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Wei, Y. Q., Wang, Q. R., Zhao, X., Yang, L., Tian, L., Lu, Y., Kang, B., Lu, C. J., Huang, M. J., Lou, Y. Y., Xiao, F., He, Q. M., Shu, J. M., Xie, X. J., Mao, Y. Q., Lei, S., Luo, F., Zhou, L. Q., Liu, C. E., ... Liu, J. Y. (2000). Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine. Nature Medicine, 6(10), 1160-1166. https://doi.org/10.1038/80506