Immunotherapy of lymphomas

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Lymphoid malignancies typically promote an infiltrate of immune cells at sites involved by the disease. While some of the immune cells present in lymphoma have effector function, the immune system is unable to eradicate the malignant clone. Therapies that optimize immune function therefore have the potential to improve the outcome of lymphoma patients. In this Review, we discuss immunologic approaches that directly target the malignant cell as well as approaches to optimize both the innate and adaptive immune response to the tumor. While many of these therapies have shown single-agent activity, the future will clearly require thoughtful combinations of these approaches.

Original languageEnglish (US)
Pages (from-to)1576-1585
Number of pages10
JournalJournal of Clinical Investigation
Volume130
Issue number4
DOIs
StatePublished - Apr 1 2020

ASJC Scopus subject areas

  • Medicine(all)

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