Immunosuppression of collagen-induced arthritis in mice with an anti-IL-2 receptor antibody

S. Banerjee, B. Y. Wei, K. Hillman, H. S. Luthra, C. S. David

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67 Scopus citations

Abstract

The use of an anti-IL-2R antibody, 7D4, was investigated in vivo in the suppression of collagen-induced arthritis in mice. 7D4 was shown to reduce the incidence of arthritis in a group of mice immunized with type II collagen as compared with a group similarly immunized with collagen and treated with a control isotype matched anti-Forsmann antibody. 7D4 was also shown to reduce the severity of arthritis in the treated mice as compared to the mice in the group treated with the control antibody. Anti-IL-2R antibodies may be useful in the treatment of autoimmune diseases by selectively suppressing activated T cells.

Original languageEnglish (US)
Pages (from-to)1150-1154
Number of pages5
JournalJournal of Immunology
Volume141
Issue number4
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Banerjee, S., Wei, B. Y., Hillman, K., Luthra, H. S., & David, C. S. (1988). Immunosuppression of collagen-induced arthritis in mice with an anti-IL-2 receptor antibody. Journal of Immunology, 141(4), 1150-1154.