Immunosuppression of collagen-induced arthritis in mice with an anti-IL-2 receptor antibody

S. Banerjee, B. Y. Wei, K. Hillman, H. S. Luthra, C. S. David

Research output: Contribution to journalArticle

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Abstract

The use of an anti-IL-2R antibody, 7D4, was investigated in vivo in the suppression of collagen-induced arthritis in mice. 7D4 was shown to reduce the incidence of arthritis in a group of mice immunized with type II collagen as compared with a group similarly immunized with collagen and treated with a control isotype matched anti-Forsmann antibody. 7D4 was also shown to reduce the severity of arthritis in the treated mice as compared to the mice in the group treated with the control antibody. Anti-IL-2R antibodies may be useful in the treatment of autoimmune diseases by selectively suppressing activated T cells.

Original languageEnglish (US)
Pages (from-to)1150-1154
Number of pages5
JournalJournal of Immunology
Volume141
Issue number4
StatePublished - 1988

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Experimental Arthritis
Interleukin-2 Receptors
Immunosuppression
Antibodies
Arthritis
Collagen Type II
Autoimmune Diseases
Anti-Idiotypic Antibodies
Collagen
T-Lymphocytes
Incidence
Therapeutics

ASJC Scopus subject areas

  • Immunology

Cite this

Banerjee, S., Wei, B. Y., Hillman, K., Luthra, H. S., & David, C. S. (1988). Immunosuppression of collagen-induced arthritis in mice with an anti-IL-2 receptor antibody. Journal of Immunology, 141(4), 1150-1154.

Immunosuppression of collagen-induced arthritis in mice with an anti-IL-2 receptor antibody. / Banerjee, S.; Wei, B. Y.; Hillman, K.; Luthra, H. S.; David, C. S.

In: Journal of Immunology, Vol. 141, No. 4, 1988, p. 1150-1154.

Research output: Contribution to journalArticle

Banerjee, S, Wei, BY, Hillman, K, Luthra, HS & David, CS 1988, 'Immunosuppression of collagen-induced arthritis in mice with an anti-IL-2 receptor antibody', Journal of Immunology, vol. 141, no. 4, pp. 1150-1154.
Banerjee S, Wei BY, Hillman K, Luthra HS, David CS. Immunosuppression of collagen-induced arthritis in mice with an anti-IL-2 receptor antibody. Journal of Immunology. 1988;141(4):1150-1154.
Banerjee, S. ; Wei, B. Y. ; Hillman, K. ; Luthra, H. S. ; David, C. S. / Immunosuppression of collagen-induced arthritis in mice with an anti-IL-2 receptor antibody. In: Journal of Immunology. 1988 ; Vol. 141, No. 4. pp. 1150-1154.
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