Abstract
The use of an anti-IL-2R antibody, 7D4, was investigated in vivo in the suppression of collagen-induced arthritis in mice. 7D4 was shown to reduce the incidence of arthritis in a group of mice immunized with type II collagen as compared with a group similarly immunized with collagen and treated with a control isotype matched anti-Forsmann antibody. 7D4 was also shown to reduce the severity of arthritis in the treated mice as compared to the mice in the group treated with the control antibody. Anti-IL-2R antibodies may be useful in the treatment of autoimmune diseases by selectively suppressing activated T cells.
Original language | English (US) |
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Pages (from-to) | 1150-1154 |
Number of pages | 5 |
Journal | Journal of Immunology |
Volume | 141 |
Issue number | 4 |
State | Published - 1988 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology