Immunosuppression in patients with Barrett's esophagus

M. Oka, S. E. Attwood, B. Kaul, Thomas Christopher Smyrk, T. R. DeMeester

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background. Patients with Barrett's esophagus have a higher incidence of esophageal cancer than has the general population. Local tissue injury and exposure to carcinogens presumably play a role in malignant transformation, but the possibility of altered host immune surveillance must also be considered. Methods. The level of immunoreactivity was investigated in six healthy control subjects; 14 patients with gastroesophageal reflux, seven with and seven without esophagitis; and nine patients with Barrett's esophagus. Parameters studied were (1) T-cell and B-cell function with mitogen-stimulated lymphocyte blastogenesis, (2) immunosuppressive properties of autologous serum, and (3) interleukin-2 production by peripheral blood mononuclear cells. Nutritional status as a possible cause for immunosuppression was assessed by measurement of serum albumin, transferrin, and prealbumin. Results. Patients with Barrett's esophagus had a significant suppression of all T-cell (p < 0.01) and B-cell function (p < 0.01) and interleukin-2 production (p < 0.001) when they were compared to the controls. Interleukin-2 production was also reduced significantly compared to that in patients with gastroesophageal reflux with and without esophagitis (p < 0.05). No differences were observed in serum immunosuppression or nutritional factors. Conclusions. Although the immunosuppression observed in the patients with Barrett's esophagus was milder than that found in other immunocompromised states, it may be sufficient to encourage the malignant transformation of Barrett's mucosa.

Original languageEnglish (US)
Pages (from-to)11-17
Number of pages7
JournalSurgery
Volume112
Issue number1
StatePublished - 1992
Externally publishedYes

Fingerprint

Barrett Esophagus
Immunosuppression
Interleukin-2
Esophagitis
Gastroesophageal Reflux
B-Lymphocytes
T-Lymphocytes
Prealbumin
Immunosuppressive Agents
Transferrin
Esophageal Neoplasms
Lymphocyte Activation
Nutritional Status
Serum
Mitogens
Serum Albumin
Carcinogens
Blood Cells
Healthy Volunteers
Mucous Membrane

ASJC Scopus subject areas

  • Surgery

Cite this

Oka, M., Attwood, S. E., Kaul, B., Smyrk, T. C., & DeMeester, T. R. (1992). Immunosuppression in patients with Barrett's esophagus. Surgery, 112(1), 11-17.

Immunosuppression in patients with Barrett's esophagus. / Oka, M.; Attwood, S. E.; Kaul, B.; Smyrk, Thomas Christopher; DeMeester, T. R.

In: Surgery, Vol. 112, No. 1, 1992, p. 11-17.

Research output: Contribution to journalArticle

Oka, M, Attwood, SE, Kaul, B, Smyrk, TC & DeMeester, TR 1992, 'Immunosuppression in patients with Barrett's esophagus', Surgery, vol. 112, no. 1, pp. 11-17.
Oka M, Attwood SE, Kaul B, Smyrk TC, DeMeester TR. Immunosuppression in patients with Barrett's esophagus. Surgery. 1992;112(1):11-17.
Oka, M. ; Attwood, S. E. ; Kaul, B. ; Smyrk, Thomas Christopher ; DeMeester, T. R. / Immunosuppression in patients with Barrett's esophagus. In: Surgery. 1992 ; Vol. 112, No. 1. pp. 11-17.
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