TY - JOUR
T1 - Immunosuppression by anti-cd4 treatment in vivo
AU - Cornelia, M. Weyand
AU - Goronzy, Jorg
AU - Swarztrauber, Kari
AU - Fathman, C. Garrison
PY - 1989/6
Y1 - 1989/6
N2 - Antibody-mediated elimination of CD4+ lymphocytes in vivo has been successfully used to suppress the hu-moral response to foreign antigens and to induce long- term tolerance. However, secondary humoral responses, as well as secondary cytolytic responses specific for viral antigens, could not be prevented, providing evidence for functional heterogeneity within the helper cell compartment. Data presented here support the notion that helper cell requirements for cellular responses to alloantigens are unique and do not involve CD4+ T lymphocytes. While the administration of anti-CD4 mcAb failed to suppress allospecific CTL responses, the formation of alloantibodies was initially inhibited in parallel to the deficiency in CD4+ helper cells. After regeneration of CD4+ T cells, the animals regained the ability to produce specific IgG alloantibodies. The dichotomy of helper pathways in humoral and cellular alloreactive responses challenges the concept of a single CD4+ helper cell population. Insights into the functional heterogeneity of helper cells for primary, secondary, and allospecific responses might open new avenues for selective manipulation of helper subpopulations
AB - Antibody-mediated elimination of CD4+ lymphocytes in vivo has been successfully used to suppress the hu-moral response to foreign antigens and to induce long- term tolerance. However, secondary humoral responses, as well as secondary cytolytic responses specific for viral antigens, could not be prevented, providing evidence for functional heterogeneity within the helper cell compartment. Data presented here support the notion that helper cell requirements for cellular responses to alloantigens are unique and do not involve CD4+ T lymphocytes. While the administration of anti-CD4 mcAb failed to suppress allospecific CTL responses, the formation of alloantibodies was initially inhibited in parallel to the deficiency in CD4+ helper cells. After regeneration of CD4+ T cells, the animals regained the ability to produce specific IgG alloantibodies. The dichotomy of helper pathways in humoral and cellular alloreactive responses challenges the concept of a single CD4+ helper cell population. Insights into the functional heterogeneity of helper cells for primary, secondary, and allospecific responses might open new avenues for selective manipulation of helper subpopulations
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U2 - 10.1097/00007890-198906000-00024
DO - 10.1097/00007890-198906000-00024
M3 - Article
C2 - 2472024
AN - SCOPUS:84945008882
SN - 0041-1337
VL - 47
SP - 1039
EP - 1042
JO - Transplantation
JF - Transplantation
IS - 6
ER -