Immunosenescence: Role and measurement in influenza vaccine response among the elderly

Paul V. Targonski; Robert M. Jacobson; Gregory A. Poland

doi:10.1016/j.vaccine.2007.01.025

Immunosenescence: Role and measurement in influenza vaccine response among the elderly

Paul V. Targonski, Robert M. Jacobson, Gregory A. Poland

Research output: Contribution to journal › Article › peer-review

137 Scopus citations

Abstract

Immunosenescence refers to the inability of an aging immune system to produce an appropriate and effective response to challenge. This immune dysfunction may manifest as increased susceptibility to infection, cancer, autoimmune disease, and vaccine failure. Mounting biological evidence supports the potential clinical relevance and impact of immunosenenscence. We briefly review immunosenescence with a focus on replicative senescence in cytotoxic T cells and recent clinical studies examining its association with influenza and infectious disease outcomes.

Original language	English (US)
Pages (from-to)	3066-3069
Number of pages	4
Journal	Vaccine
Volume	25
Issue number	16 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.vaccine.2007.01.025
State	Published - Apr 20 2007

Keywords

Immunosenescence
Influenza
Telomerase

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/j.vaccine.2007.01.025

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AU - Jacobson, Robert M.

AU - Poland, Gregory A.

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AB - Immunosenescence refers to the inability of an aging immune system to produce an appropriate and effective response to challenge. This immune dysfunction may manifest as increased susceptibility to infection, cancer, autoimmune disease, and vaccine failure. Mounting biological evidence supports the potential clinical relevance and impact of immunosenenscence. We briefly review immunosenescence with a focus on replicative senescence in cytotoxic T cells and recent clinical studies examining its association with influenza and infectious disease outcomes.

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KW - Telomerase

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IS - 16 SPEC. ISS.

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Immunosenescence: Role and measurement in influenza vaccine response among the elderly

Abstract

Keywords

ASJC Scopus subject areas

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