Immunosenescence: Role and measurement in influenza vaccine response among the elderly

Paul V. Targonski, Robert M. Jacobson, Gregory A. Poland

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

Immunosenescence refers to the inability of an aging immune system to produce an appropriate and effective response to challenge. This immune dysfunction may manifest as increased susceptibility to infection, cancer, autoimmune disease, and vaccine failure. Mounting biological evidence supports the potential clinical relevance and impact of immunosenenscence. We briefly review immunosenescence with a focus on replicative senescence in cytotoxic T cells and recent clinical studies examining its association with influenza and infectious disease outcomes.

Original languageEnglish (US)
Pages (from-to)3066-3069
Number of pages4
JournalVaccine
Volume25
Issue number16 SPEC. ISS.
DOIs
StatePublished - Apr 20 2007

Fingerprint

Influenza Vaccines
autoimmune diseases
influenza
infectious diseases
immune system
clinical trials
T-lymphocytes
vaccines
neoplasms
Cell Aging
infection
Human Influenza
Autoimmune Diseases
Communicable Diseases
Immune System
Vaccines
T-Lymphocytes
Infection
Neoplasms
Immunosenescence

Keywords

  • Immunosenescence
  • Influenza
  • Telomerase

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

Targonski, P. V., Jacobson, R. M., & Poland, G. A. (2007). Immunosenescence: Role and measurement in influenza vaccine response among the elderly. Vaccine, 25(16 SPEC. ISS.), 3066-3069. https://doi.org/10.1016/j.vaccine.2007.01.025

Immunosenescence : Role and measurement in influenza vaccine response among the elderly. / Targonski, Paul V.; Jacobson, Robert M.; Poland, Gregory A.

In: Vaccine, Vol. 25, No. 16 SPEC. ISS., 20.04.2007, p. 3066-3069.

Research output: Contribution to journalArticle

Targonski, PV, Jacobson, RM & Poland, GA 2007, 'Immunosenescence: Role and measurement in influenza vaccine response among the elderly', Vaccine, vol. 25, no. 16 SPEC. ISS., pp. 3066-3069. https://doi.org/10.1016/j.vaccine.2007.01.025
Targonski, Paul V. ; Jacobson, Robert M. ; Poland, Gregory A. / Immunosenescence : Role and measurement in influenza vaccine response among the elderly. In: Vaccine. 2007 ; Vol. 25, No. 16 SPEC. ISS. pp. 3066-3069.
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