Immunophenotyping in multiple myeloma and related plasma cell disorders

Shaji Kumar, Teresa Kimlinger, William Morice

Research output: Contribution to journalReview article

61 Scopus citations

Abstract

Plasma cell disorders form a spectrum ranging from the asymptomatic presence of small monoclonal populations of plasma cells to conditions like plasma cell leukemia and multiple myeloma, in which the bone marrow can be replaced by the accumulation of neoplastic plasma cells. Immunophenotyping has become an invaluable tool in the management of hematological malignancies and is increasingly finding a role in the diagnosis and monitoring of plasma cell disorders. Multiparameter flow cytometry has evolved considerably during the past decade with an increasing ability to screen large numbers of events and to detect multiple antigens at the same time. This, along with a better understanding of the phenotypic heterogeneity of the clonal plasma cells in different disorders, has made immunophenotyping an indispensible tool in the diagnosis, prognostic classification and management of plasma cell disorders. This book chapter addresses the approaches taken to evaluate monoclonal plasma cell disorders, and the different markers and techniques that are important for the study of these diseases.

Original languageEnglish (US)
Pages (from-to)433-451
Number of pages19
JournalBest Practice and Research: Clinical Haematology
Volume23
Issue number3
DOIs
StatePublished - Sep 1 2010

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Keywords

  • Immunophenotyping
  • Monoclonal gammopathy
  • Myeloma
  • Plasma cell

ASJC Scopus subject areas

  • Oncology
  • Clinical Biochemistry

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