Immunomodulating therapy in liver transplantation: Principles and practice

Jody C. Olson, Russell H. Wiesner

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Liver transplantation has enjoyed dramatic success as a treatment option for patients suffering from chronic end-stage liver diseases. It also serves as a definitive treatment for certain genetic conditions such as familial amyloidosis and primary oxalosis, and as a potential curative therapy in selected cases of primary liver cancer. Currently, over 50,000 patients are alive with functioning liver transplants. Liver transplantation owes its success to advances in surgical technique, improvements in anesthesia and critical care, and advances in treatment of post-transplant complications including improved therapies for cytomegalovirus infections. But perhaps the most important advances in liver transplantation arise in the context of improvements in our understanding of the molecular biology of transplant immunology and the development of new agents that allow for manipulation of immunological signaling pathways. These improvements in immunosuppressive therapy have dramatically increased both graft and patient survival.

Original languageEnglish (US)
Pages (from-to)793-805
Number of pages13
JournalImmunotherapy
Volume4
Issue number8
DOIs
StatePublished - Aug 2012

Fingerprint

Liver Transplantation
Transplants
Therapeutics
Familial Amyloidosis
Primary Hyperoxaluria
End Stage Liver Disease
Cytomegalovirus Infections
Graft Survival
Critical Care
Liver Neoplasms
Immunosuppressive Agents
Allergy and Immunology
Molecular Biology
Anesthesia
Liver

Keywords

  • azathioprine
  • cyclosporine
  • immunosuppression
  • liver
  • mycophenolate mofetil
  • sirolimus
  • tacrolimus
  • transplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

Cite this

Immunomodulating therapy in liver transplantation : Principles and practice. / Olson, Jody C.; Wiesner, Russell H.

In: Immunotherapy, Vol. 4, No. 8, 08.2012, p. 793-805.

Research output: Contribution to journalArticle

Olson, Jody C. ; Wiesner, Russell H. / Immunomodulating therapy in liver transplantation : Principles and practice. In: Immunotherapy. 2012 ; Vol. 4, No. 8. pp. 793-805.
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