Immunometabolism and atherosclerosis: Perspectives and clinical significance: A position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology

Daniel F.J. Ketelhuth; Esther Lutgens; Magnus Bäck; Christoph J. Binder; Jan Van Den Bossche; Carolin Daniel; Ingrid E. Dumitriu; Imo Hoefer; Peter Libby; Luke O'Neill; Christian Weber; Paul C. Evans

doi:10.1093/cvr/cvz166

Immunometabolism and atherosclerosis: Perspectives and clinical significance: A position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology

Daniel F.J. Ketelhuth, Esther Lutgens, Magnus Bäck, Christoph J. Binder, Jan Van Den Bossche, Carolin Daniel, Ingrid E. Dumitriu, Imo Hoefer, Peter Libby, Luke O'Neill, Christian Weber, Paul C. Evans

Cardiovascular Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Inflammation is an important driver of atherosclerosis, and the favourable outcomes of the Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial revealed the large potential of anti-inflammatory drugs for the treatment of cardiovascular disease, especially in patients with a pro-inflammatory constitution. However, the complex immune reactions driving inflammation in the vascular wall in response to an atherosclerotic microenvironment are still being unravelled. Novel insights into the cellular processes driving immunity and inflammation revealed that alterations in intracellular metabolic pathways are strong drivers of survival, growth, and function of immune cells. Therefore, this position paper presents a brief overview of the recent developments in the immunometabolism field, focusing on its role in atherosclerosis. We will also highlight the potential impact of immunometabolic markers and targets in clinical cardiovascular medicine.

Original language	English (US)
Pages (from-to)	1385-1392
Number of pages	8
Journal	Cardiovascular research
Volume	115
Issue number	9
DOIs	https://doi.org/10.1093/cvr/cvz166
State	Published - Jul 15 2019

Keywords

Atherosclerosis
Immune system
Inflammation
Metabolism
Vascular

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine
Physiology (medical)

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10.1093/cvr/cvz166

Cite this

Ketelhuth, D. F. J., Lutgens, E., Bäck, M., Binder, C. J., Van Den Bossche, J., Daniel, C., Dumitriu, I. E., Hoefer, I., Libby, P., O'Neill, L., Weber, C., & Evans, P. C. (2019). Immunometabolism and atherosclerosis: Perspectives and clinical significance: A position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology. Cardiovascular research, 115(9), 1385-1392. https://doi.org/10.1093/cvr/cvz166

Immunometabolism and atherosclerosis: Perspectives and clinical significance: A position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology. / Ketelhuth, Daniel F.J.; Lutgens, Esther; Bäck, Magnus et al.
In: Cardiovascular research, Vol. 115, No. 9, 15.07.2019, p. 1385-1392.

Research output: Contribution to journal › Article › peer-review

Ketelhuth, DFJ, Lutgens, E, Bäck, M, Binder, CJ, Van Den Bossche, J, Daniel, C, Dumitriu, IE, Hoefer, I, Libby, P, O'Neill, L, Weber, C & Evans, PC 2019, 'Immunometabolism and atherosclerosis: Perspectives and clinical significance: A position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology', Cardiovascular research, vol. 115, no. 9, pp. 1385-1392. https://doi.org/10.1093/cvr/cvz166

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Immunometabolism and atherosclerosis: Perspectives and clinical significance: A position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology

Abstract

Keywords

ASJC Scopus subject areas

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