Immunology of liver transplantation: Clinical management aspects

Vijay Shah, A. L. Friedman, V. J. Navarro

Research output: Contribution to journalArticle

Abstract

Orthotopic liver transplantation has developed into the treatment of choice for many patients who develop complications of end-stage liver disease. With improvements in surgical technique and overall survival since the inception of liver grafting, a major consideration in the long-term care of liver transplant patients has become the management of allograft rejection and immunosuppressive therapy. With an increasing number of patients having undergone successful transplantation in the community, practicing gastroenterologists will likely be called upon more frequently to render care to these patients. In this article, the immunobiology of transplantation and rejection is discussed with an emphasis placed on the T-cell - major histocompatibility complex interaction, cytokine stimulation, and adhesion molecule binding. Commonly used immunosuppressive medications and promising ones for the future are reviewed. Also, clinical aspects of the short- and long-term management of immunosuppression are explored.

Original languageEnglish (US)
Pages (from-to)137-147
Number of pages11
JournalGastroenterologist
Volume5
Issue number2
StatePublished - 1997
Externally publishedYes

Fingerprint

Allergy and Immunology
Liver Transplantation
Immunosuppressive Agents
End Stage Liver Disease
Graft Rejection
Long-Term Care
Major Histocompatibility Complex
Immunosuppression
Allografts
Patient Care
Transplantation
Cytokines
T-Lymphocytes
Transplants
Survival
Liver
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Shah, V., Friedman, A. L., & Navarro, V. J. (1997). Immunology of liver transplantation: Clinical management aspects. Gastroenterologist, 5(2), 137-147.

Immunology of liver transplantation : Clinical management aspects. / Shah, Vijay; Friedman, A. L.; Navarro, V. J.

In: Gastroenterologist, Vol. 5, No. 2, 1997, p. 137-147.

Research output: Contribution to journalArticle

Shah, V, Friedman, AL & Navarro, VJ 1997, 'Immunology of liver transplantation: Clinical management aspects', Gastroenterologist, vol. 5, no. 2, pp. 137-147.
Shah, Vijay ; Friedman, A. L. ; Navarro, V. J. / Immunology of liver transplantation : Clinical management aspects. In: Gastroenterologist. 1997 ; Vol. 5, No. 2. pp. 137-147.
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