Immunology of Inflammatory Bowel Disease and Molecular Targets for Biologics

Research output: Contribution to journalReview article

32 Scopus citations

Abstract

Inflammatory bowel disease (IBD) is an immune-mediated disease and involves a complex interplay of host genetics and environmental influences. Recent advances in the field, including data from genome-wide association studies and microbiome analysis, have started to unravel the complex interaction between host genetics and environmental influences in the pathogenesis of IBD. A drawback of current clinical trials is inadequate or lack of immune phenotyping of patients. However, recent advances in high-throughput technologies provide an opportunity to monitor the dynamic and complex immune system, which may to lead to a more personalized treatment approach in IBD.

Original languageEnglish (US)
Pages (from-to)405-424
Number of pages20
JournalGastroenterology Clinics of North America
Volume43
Issue number3
DOIs
StatePublished - Sep 2014

Keywords

  • Adaptive immunity
  • Biologics
  • IBD
  • Immunology
  • Innate immunity

ASJC Scopus subject areas

  • Gastroenterology

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