Immunological study of a chitosan prosthesis in the sciatic nerve regeneration of the axotomized dog

M. Rosales-Cobtés; J. Peregrina-Sandoval; J. Bañuelos-Pineda; R. Sarabia-Estrada; C. C. Gómez-Rodiles; E. Albarrán-Rodríguez; G. P. Zaitseva; M. L. Pita-López

doi:10.1177/0885328203018001002

Immunological study of a chitosan prosthesis in the sciatic nerve regeneration of the axotomized dog

M. Rosales-Cobtés, J. Peregrina-Sandoval, J. Bañuelos-Pineda, R. Sarabia-Estrada, C. C. Gómez-Rodiles, E. Albarrán-Rodríguez, G. P. Zaitseva, M. L. Pita-López

Neurosurgery

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

This study demonstrated that when the regeneration of the axotomized sciatic nerve is induced through tubulization with chitosan, this biomaterial does not induce immunostimulation or immunodepression in the dog. Canine females were distributed among three groups: an intact control group which was only isolated, an axotomized control group, and an axotomized group which was tubulized with 3% chitosan prostheses. In vitro culture and phagocytosis tests, as well as IgG and IgM serum concentrations, were determined in peripheral blood on days 0, 15, 30 and 60. The results showed that chitosan implants did not importantly affect the immune response.

Original language	English (US)
Pages (from-to)	15-23
Number of pages	9
Journal	Journal of Biomaterials Applications
Volume	18
Issue number	1
DOIs	https://doi.org/10.1177/0885328203018001002
State	Published - Jul 2003

Keywords

Biomaterial
Cellular immune response
Chitosan
Humoral immune response
Immunological study
Sciatic nerve

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering

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10.1177/0885328203018001002

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Rosales-Cobtés, M., Peregrina-Sandoval, J., Bañuelos-Pineda, J., Sarabia-Estrada, R., Gómez-Rodiles, C. C., Albarrán-Rodríguez, E., Zaitseva, G. P., & Pita-López, M. L. (2003). Immunological study of a chitosan prosthesis in the sciatic nerve regeneration of the axotomized dog. Journal of Biomaterials Applications, 18(1), 15-23. https://doi.org/10.1177/0885328203018001002

Rosales-Cobtés, M, Peregrina-Sandoval, J, Bañuelos-Pineda, J, Sarabia-Estrada, R, Gómez-Rodiles, CC, Albarrán-Rodríguez, E, Zaitseva, GP & Pita-López, ML 2003, 'Immunological study of a chitosan prosthesis in the sciatic nerve regeneration of the axotomized dog', Journal of Biomaterials Applications, vol. 18, no. 1, pp. 15-23. https://doi.org/10.1177/0885328203018001002

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AU - Sarabia-Estrada, R.

AU - Gómez-Rodiles, C. C.

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Immunological study of a chitosan prosthesis in the sciatic nerve regeneration of the axotomized dog

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Keywords

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