Immunological study of a chitosan prosthesis in the sciatic nerve regeneration of the axotomized dog

M. Rosales-Cobtés, J. Peregrina-Sandoval, J. Bañuelos-Pineda, Rachel Sarabia Estrada, C. C. Gómez-Rodiles, E. Albarrán-Rodríguez, G. P. Zaitseva, M. L. Pita-López

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

This study demonstrated that when the regeneration of the axotomized sciatic nerve is induced through tubulization with chitosan, this biomaterial does not induce immunostimulation or immunodepression in the dog. Canine females were distributed among three groups: an intact control group which was only isolated, an axotomized control group, and an axotomized group which was tubulized with 3% chitosan prostheses. In vitro culture and phagocytosis tests, as well as IgG and IgM serum concentrations, were determined in peripheral blood on days 0, 15, 30 and 60. The results showed that chitosan implants did not importantly affect the immune response.

Original languageEnglish (US)
Pages (from-to)15-23
Number of pages9
JournalJournal of Biomaterials Applications
Volume18
Issue number1
DOIs
StatePublished - Jul 2003
Externally publishedYes

Fingerprint

Chitosan
Biocompatible Materials
Prosthetics
Biomaterials
Immunoglobulin M
Blood
Immunoglobulin G
Prostheses and Implants

Keywords

  • Biomaterial
  • Cellular immune response
  • Chitosan
  • Humoral immune response
  • Immunological study
  • Sciatic nerve

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

Cite this

Rosales-Cobtés, M., Peregrina-Sandoval, J., Bañuelos-Pineda, J., Sarabia Estrada, R., Gómez-Rodiles, C. C., Albarrán-Rodríguez, E., ... Pita-López, M. L. (2003). Immunological study of a chitosan prosthesis in the sciatic nerve regeneration of the axotomized dog. Journal of Biomaterials Applications, 18(1), 15-23. https://doi.org/10.1177/0885328203018001002

Immunological study of a chitosan prosthesis in the sciatic nerve regeneration of the axotomized dog. / Rosales-Cobtés, M.; Peregrina-Sandoval, J.; Bañuelos-Pineda, J.; Sarabia Estrada, Rachel; Gómez-Rodiles, C. C.; Albarrán-Rodríguez, E.; Zaitseva, G. P.; Pita-López, M. L.

In: Journal of Biomaterials Applications, Vol. 18, No. 1, 07.2003, p. 15-23.

Research output: Contribution to journalArticle

Rosales-Cobtés, M, Peregrina-Sandoval, J, Bañuelos-Pineda, J, Sarabia Estrada, R, Gómez-Rodiles, CC, Albarrán-Rodríguez, E, Zaitseva, GP & Pita-López, ML 2003, 'Immunological study of a chitosan prosthesis in the sciatic nerve regeneration of the axotomized dog', Journal of Biomaterials Applications, vol. 18, no. 1, pp. 15-23. https://doi.org/10.1177/0885328203018001002
Rosales-Cobtés M, Peregrina-Sandoval J, Bañuelos-Pineda J, Sarabia Estrada R, Gómez-Rodiles CC, Albarrán-Rodríguez E et al. Immunological study of a chitosan prosthesis in the sciatic nerve regeneration of the axotomized dog. Journal of Biomaterials Applications. 2003 Jul;18(1):15-23. https://doi.org/10.1177/0885328203018001002
Rosales-Cobtés, M. ; Peregrina-Sandoval, J. ; Bañuelos-Pineda, J. ; Sarabia Estrada, Rachel ; Gómez-Rodiles, C. C. ; Albarrán-Rodríguez, E. ; Zaitseva, G. P. ; Pita-López, M. L. / Immunological study of a chitosan prosthesis in the sciatic nerve regeneration of the axotomized dog. In: Journal of Biomaterials Applications. 2003 ; Vol. 18, No. 1. pp. 15-23.
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