Immunological responses of guinea pigs to a synthetic autoantigen of brain

Vanda A Lennon, P. R. Carnegie

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A synthetic peptide, Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg, of identical sequence to residues 112 to 122 of the basic protein of human myelin was active in guinea pigs in inducing experimental autoimmune encephalomyelitis. This peptide did not induce a humoral immune response, but a cellular immune response was obtained, as judged by transformation of splenic lymphocytes when these were cultured with the human encephalitogenic protein, and by demonstration of macrophage inhibitory factor when peritoneal exudate cells were incubated with the protein.

Original languageEnglish (US)
Pages (from-to)60-62
Number of pages3
JournalEuropean Journal of Immunology
Volume4
Issue number1
StatePublished - 1974
Externally publishedYes

Fingerprint

Autoantigens
Guinea Pigs
Peptides
Autoimmune Experimental Encephalomyelitis
Brain
Exudates and Transudates
Lymphocyte Activation
Humoral Immunity
Cellular Immunity
Proteins
Macrophages
human MBP protein

ASJC Scopus subject areas

  • Immunology

Cite this

Immunological responses of guinea pigs to a synthetic autoantigen of brain. / Lennon, Vanda A; Carnegie, P. R.

In: European Journal of Immunology, Vol. 4, No. 1, 1974, p. 60-62.

Research output: Contribution to journalArticle

@article{3dc8d26eac594038b37ef5fc40bdf02d,
title = "Immunological responses of guinea pigs to a synthetic autoantigen of brain",
abstract = "A synthetic peptide, Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg, of identical sequence to residues 112 to 122 of the basic protein of human myelin was active in guinea pigs in inducing experimental autoimmune encephalomyelitis. This peptide did not induce a humoral immune response, but a cellular immune response was obtained, as judged by transformation of splenic lymphocytes when these were cultured with the human encephalitogenic protein, and by demonstration of macrophage inhibitory factor when peritoneal exudate cells were incubated with the protein.",
author = "Lennon, {Vanda A} and Carnegie, {P. R.}",
year = "1974",
language = "English (US)",
volume = "4",
pages = "60--62",
journal = "European Journal of Immunology",
issn = "0014-2980",
publisher = "Wiley-VCH Verlag",
number = "1",

}

TY - JOUR

T1 - Immunological responses of guinea pigs to a synthetic autoantigen of brain

AU - Lennon, Vanda A

AU - Carnegie, P. R.

PY - 1974

Y1 - 1974

N2 - A synthetic peptide, Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg, of identical sequence to residues 112 to 122 of the basic protein of human myelin was active in guinea pigs in inducing experimental autoimmune encephalomyelitis. This peptide did not induce a humoral immune response, but a cellular immune response was obtained, as judged by transformation of splenic lymphocytes when these were cultured with the human encephalitogenic protein, and by demonstration of macrophage inhibitory factor when peritoneal exudate cells were incubated with the protein.

AB - A synthetic peptide, Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg, of identical sequence to residues 112 to 122 of the basic protein of human myelin was active in guinea pigs in inducing experimental autoimmune encephalomyelitis. This peptide did not induce a humoral immune response, but a cellular immune response was obtained, as judged by transformation of splenic lymphocytes when these were cultured with the human encephalitogenic protein, and by demonstration of macrophage inhibitory factor when peritoneal exudate cells were incubated with the protein.

UR - http://www.scopus.com/inward/record.url?scp=0015978105&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015978105&partnerID=8YFLogxK

M3 - Article

C2 - 4136801

AN - SCOPUS:0015978105

VL - 4

SP - 60

EP - 62

JO - European Journal of Immunology

JF - European Journal of Immunology

SN - 0014-2980

IS - 1

ER -