Immunological features of fibrodysplasia ossificans progressiva and the dysregulated BMP4 pathway

Frederick S. Kaplan, Eileen M. Shore, Rishi Gupta, Paul C. Billings, David L. Glaser, Robert J. Pignolo, Daniel Graf, Malek Kamoun

Research output: Contribution to journalReview article

32 Scopus citations

Abstract

Dysregulation of the bone morphogenic protein (BMP)4-signaling pathway can explain many developmental and postnatal features of fibrodysplasia ossificans progressive (FOP). However, many puzzling clinical features of the disease strongly implicate an underlying immunological component to the disorder. In this article, we review features of the BMP4 signaling pathway that regulate the immune system, and suggest an integrated hypothesis for FOP that accounts for both BMP-related abnormalities and immunological features of the condition.

Original languageEnglish (US)
Pages (from-to)189-193
Number of pages5
JournalClinical Reviews in Bone and Mineral Metabolism
Volume3
Issue number3-4
DOIs
StatePublished - Sep 1 2005

Keywords

  • Autoimmunity
  • Bone morphogenic protein (BMP)4-signaling pathway
  • Fibrodysplasia ossificans progressiva (FOP)
  • Immune system

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

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