Immunolocalization of calcitriol receptor, plasma membrane calcium pump and calbindin-D 28k in the cornea and ciliary body of the rat eye

Julie A. Johnson, Joseph P. Grande, Patrick C. Roche, R. Jean Campbell, Rajiv Kumar

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Epitopes of the calcitriol receptor, the ATP-dependent plasma membrane calcium pump (PMCA) and the 28-kD vitamin-D-dependent Ca-binding protein (calbindin-D28k) were detected in sections of the albino rat eye using light microscopy and immunohistochemistry of paraffin-embedded tissues. Calcitriol receptor and calbindin-D28k epitopes were detected in both the inner and outer layers of the ciliary body epithelium. PMC A was present in both epithelial cell layers of the ciliary body but was most prominent in the inner layer. Corneal epithelium and endothelium also contained epitopes for calcitriol receptor, PMCA and calbindin-D28k These Ca-regulatory proteins may play a role in the cellular physiology of the albino rat eye by maintaining appropriate intracellular and aqueous humor Ca concentrations.

Original languageEnglish (US)
Pages (from-to)42-47
Number of pages6
JournalOphthalmic Research
Volume27
Issue number1
DOIs
StatePublished - Jan 1 1995

Keywords

  • Calbindin-D
  • Calcitriol receptor
  • Ciliary body
  • Cornea
  • Plasma membrane calcium
  • Pump
  • Rat

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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