Immunohistochemical study of the hippocampus in parkinsonism-dementia complex on Guam

H. Ito, S. Goto, A. Hirano, S. H C Yen

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

This investigation concerns the expression of paired helical filaments, tau protein, ubiquitin, β-amyloid protein, and synaptophysin in the hippocampus of patients with parkinsonism-dementia complex on Guam (PDC) and Alzheimer's disease. Alzheimer's neurofibrillary tangles (NFTs) were identified in all cases of PDC and Alzheimer's disease by the modified Bielschowsky method, with which they were readily detected, and by immunohistochemical procedures using antibodies to paired helical filaments, tau protein, and ubiquitin. Observations regarding the different morphological stages indicated that NFTs were similar in PDC and Alzheimer's disease. The same markers were also useful for detecting neuropil threads, abundant in the CA1 field and the subiculum in both diseases. In the CA4 region of some PDC cases, prominent threads were noted. No senile plaques or amyloid angiopathies were seen in the hippocampus of the PDC cases examined. There was a significant decrease in synaptophysin immunoreactivity, most pronounced in the subfield CA1 and the subiculum, as well as in the outer molecular layer of the dentate gyrus, in both disorders.

Original languageEnglish (US)
Pages (from-to)134-142
Number of pages9
JournalJournal of Geriatric Psychiatry and Neurology
Volume4
Issue number3
StatePublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

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