Immunoglobulins promote remyelination in the central nervous system

Moses Rodriguez, Vanda A. Lennon

Research output: Contribution to journalArticle

204 Scopus citations

Abstract

Remyelination of central nervous system axons was promoted by systemic injection of serum immunoglobulin G (IgG) from donor mice hyperimmunized with homogenized spinal cord. In SJL/J mice infected with Theiler's virus, primary demyelination and inflammation in the spinal cord were extensive. Following treatment with IgG to spinal cord homogenate, new myelin synthesis as measured by quantitative morphometry increased sixfold. Cells in areas of remyelination that incorporated [3H]thymidine did not express differentiation markers of macrophages, oligodendrocytes, or astrocytes but were identified by electron microscopic autoradiography as progenitor glial cells. These findings raise the possibility that IgG secreted in demyelination lesions might have the protential to promote myelin repair.

Original languageEnglish (US)
Pages (from-to)12-17
Number of pages6
JournalAnnals of neurology
Volume27
Issue number1
DOIs
StatePublished - Jan 1990

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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