Immunoglobulin specificity of low grade B cell gastrointestinal lymphoma of mucosa-associated lymphoid tissue (MALT) type

T. Hussell, P. G. Isaacson, J. E. Crabtree, A. Dogan, J. Spencer

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124 Scopus citations

Abstract

The specificity of the tumor cell immunoglobulin in three cases of low grade B cell gastrointestinal mucosa-associated lymphoid tissue (MALT) lymphoma has been studied. Using anti-idiotypic antibodies to detect the reactivity of tumor immunoglobulin in tissue sections from the patients and other individuals, we observed specificity for normal tissue components in all three cases studied. Reactivity in one case was with follicular dendritic cells, in the second case with a novel antigen on mucosal post capillary venules, and, in the third case, a broad pattern of reactivity was observed. This study suggests that autoimmunity may play a role in the pathogenesis of gastric lymphoma.

Original languageEnglish (US)
Pages (from-to)285-292
Number of pages8
JournalAmerican Journal of Pathology
Volume142
Issue number1
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Hussell, T., Isaacson, P. G., Crabtree, J. E., Dogan, A., & Spencer, J. (1993). Immunoglobulin specificity of low grade B cell gastrointestinal lymphoma of mucosa-associated lymphoid tissue (MALT) type. American Journal of Pathology, 142(1), 285-292.