Immunoglobulin D amyloidosis: A distinct entity

Morie A. Gertz; Francis K. Buadi; Suzanne R. Hayman; David Dingli; Angela Dispenzieri; Philip R. Greipp; Shaji K. Kumar; Martha Q. Lacy; John A. Lust; Nelson Leung; S. Vincent Rajkumar; Stephen J. Russell; Steven R. Zeldenrust; Joseph R. Mikhael; Vivek Roy; Robert A. Kyle

doi:10.1182/blood-2011-06-358895

Immunoglobulin D amyloidosis: A distinct entity

Morie A. Gertz, Francis K. Buadi, Suzanne R. Hayman, David Dingli, Angela Dispenzieri, Philip R. Greipp, Shaji K. Kumar, Martha Q. Lacy, John A. Lust, Nelson Leung, S. Vincent Rajkumar, Stephen J. Russell, Steven R. Zeldenrust, Joseph R. Mikhael, Vivek Roy, Robert A. Kyle

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

IgD monoclonal gammopathies are uncommon. They are seen rarely as a monoclonal gammopathy of undetermined significance and are present in 1%-2% of patients with multiple myeloma. In light-chain amyloidosis, IgD monoclonal proteins are found in ap-proximately 1% of patients. When an IgD monoclonal protein is found, amyloidosis is often omitted from the differential diagnosis. In the present study, we reviewed the natural history of IgD-associated amyloidosis among 53 patients seen over 41 years. The distribution of clinical syndromes suggests that these patients have a lower frequency of renal and cardiac involvement. The overall survival of these patients does not appear to be different from that of patients who have light-chain amyloidosis associated with another monoclonal protein.

Original language	English (US)
Pages (from-to)	44-48
Number of pages	5
Journal	Blood
Volume	119
Issue number	1
DOIs	https://doi.org/10.1182/blood-2011-06-358895
State	Published - Jan 5 2012

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

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@article{f6285bf282124bc588b331dfb1327439,

title = "Immunoglobulin D amyloidosis: A distinct entity",

abstract = "IgD monoclonal gammopathies are uncommon. They are seen rarely as a monoclonal gammopathy of undetermined significance and are present in 1%-2% of patients with multiple myeloma. In light-chain amyloidosis, IgD monoclonal proteins are found in ap-proximately 1% of patients. When an IgD monoclonal protein is found, amyloidosis is often omitted from the differential diagnosis. In the present study, we reviewed the natural history of IgD-associated amyloidosis among 53 patients seen over 41 years. The distribution of clinical syndromes suggests that these patients have a lower frequency of renal and cardiac involvement. The overall survival of these patients does not appear to be different from that of patients who have light-chain amyloidosis associated with another monoclonal protein.",

author = "Gertz, {Morie A.} and Buadi, {Francis K.} and Hayman, {Suzanne R.} and David Dingli and Angela Dispenzieri and Greipp, {Philip R.} and Kumar, {Shaji K.} and Lacy, {Martha Q.} and Lust, {John A.} and Nelson Leung and Rajkumar, {S. Vincent} and Russell, {Stephen J.} and Zeldenrust, {Steven R.} and Mikhael, {Joseph R.} and Vivek Roy and Kyle, {Robert A.}",

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doi = "10.1182/blood-2011-06-358895",

language = "English (US)",

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T1 - Immunoglobulin D amyloidosis

T2 - A distinct entity

AU - Gertz, Morie A.

AU - Buadi, Francis K.

AU - Hayman, Suzanne R.

AU - Dingli, David

AU - Dispenzieri, Angela

AU - Greipp, Philip R.

AU - Kumar, Shaji K.

AU - Lacy, Martha Q.

AU - Lust, John A.

AU - Leung, Nelson

AU - Rajkumar, S. Vincent

AU - Russell, Stephen J.

AU - Zeldenrust, Steven R.

AU - Mikhael, Joseph R.

AU - Roy, Vivek

AU - Kyle, Robert A.

PY - 2012/1/5

Y1 - 2012/1/5

N2 - IgD monoclonal gammopathies are uncommon. They are seen rarely as a monoclonal gammopathy of undetermined significance and are present in 1%-2% of patients with multiple myeloma. In light-chain amyloidosis, IgD monoclonal proteins are found in ap-proximately 1% of patients. When an IgD monoclonal protein is found, amyloidosis is often omitted from the differential diagnosis. In the present study, we reviewed the natural history of IgD-associated amyloidosis among 53 patients seen over 41 years. The distribution of clinical syndromes suggests that these patients have a lower frequency of renal and cardiac involvement. The overall survival of these patients does not appear to be different from that of patients who have light-chain amyloidosis associated with another monoclonal protein.

AB - IgD monoclonal gammopathies are uncommon. They are seen rarely as a monoclonal gammopathy of undetermined significance and are present in 1%-2% of patients with multiple myeloma. In light-chain amyloidosis, IgD monoclonal proteins are found in ap-proximately 1% of patients. When an IgD monoclonal protein is found, amyloidosis is often omitted from the differential diagnosis. In the present study, we reviewed the natural history of IgD-associated amyloidosis among 53 patients seen over 41 years. The distribution of clinical syndromes suggests that these patients have a lower frequency of renal and cardiac involvement. The overall survival of these patients does not appear to be different from that of patients who have light-chain amyloidosis associated with another monoclonal protein.

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SP - 44

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JO - Blood

JF - Blood

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Immunoglobulin D amyloidosis: A distinct entity

Abstract

ASJC Scopus subject areas

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