Immunoglobulin complexes in sera of patients with malignancy

E. A. Samayoa, F. C. McDuffie, A. M. Nelson, V. L. Go, H. S. Luthra, H. W. Brumfield

Research output: Contribution to journalArticle

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Abstract

Sera from 146 patients with malignancy, 59 normal controls and 42 patients hospitalized with nonmalignant diseases were examined by a precipitin test with monoclonal rheumatoid factor (mRF) for the presence of circulating immune complexes containing IgG. 42 (29%) Of the sera from cancer patients but only 2 of the sera from patients in each of the control groups contained such material. Similar results were obtained with a radioimmunoassay for immune complexes based on the same mRF. Sera from 23 of 65 patients with metastatic malignancy (35%) had elevated levels of immune complexes by this latter test. The presence of the material was not related to the source of malignancy, presence of carcinoembryonic or hepatitis antigens or of such autoantibodies as rheumatoid factor or anti DNA. By density gradient ultracentrifugation the reacting material was identified as being of molecular size 19s or greater. It has not yet been further characterized with regard to the nature of any antigens present.

Original languageEnglish (US)
Pages (from-to)12-17
Number of pages6
JournalInternational Journal of Cancer
Volume19
Issue number1
DOIs
StatePublished - 1977

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Immunoglobulins
Rheumatoid Factor
Antigen-Antibody Complex
Serum
Neoplasms
Precipitin Tests
Hepatitis Antigens
Ultracentrifugation
Carcinoembryonic Antigen
Autoantibodies
Radioimmunoassay
Immunoglobulin G
Antigens
Control Groups
DNA

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Samayoa, E. A., McDuffie, F. C., Nelson, A. M., Go, V. L., Luthra, H. S., & Brumfield, H. W. (1977). Immunoglobulin complexes in sera of patients with malignancy. International Journal of Cancer, 19(1), 12-17. https://doi.org/10.1002/ijc.2910190103

Immunoglobulin complexes in sera of patients with malignancy. / Samayoa, E. A.; McDuffie, F. C.; Nelson, A. M.; Go, V. L.; Luthra, H. S.; Brumfield, H. W.

In: International Journal of Cancer, Vol. 19, No. 1, 1977, p. 12-17.

Research output: Contribution to journalArticle

Samayoa, EA, McDuffie, FC, Nelson, AM, Go, VL, Luthra, HS & Brumfield, HW 1977, 'Immunoglobulin complexes in sera of patients with malignancy', International Journal of Cancer, vol. 19, no. 1, pp. 12-17. https://doi.org/10.1002/ijc.2910190103
Samayoa EA, McDuffie FC, Nelson AM, Go VL, Luthra HS, Brumfield HW. Immunoglobulin complexes in sera of patients with malignancy. International Journal of Cancer. 1977;19(1):12-17. https://doi.org/10.1002/ijc.2910190103
Samayoa, E. A. ; McDuffie, F. C. ; Nelson, A. M. ; Go, V. L. ; Luthra, H. S. ; Brumfield, H. W. / Immunoglobulin complexes in sera of patients with malignancy. In: International Journal of Cancer. 1977 ; Vol. 19, No. 1. pp. 12-17.
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